Stimulant use is associated with immune activation and depleted tryptophan among HIV-positive persons on anti-retroviral therapy

Brain, Behavior, and Immunity

Volumn 22, Issue 8, 2008, Pages 1257-1262

  Carrico, Adam W ^a   Johnson, Mallory O ^a   Morin, Stephen F ^a   Remien, Robert H ^b   Riley, Elise D ^a,c   Hecht, Frederick M ^d   Fuchs, Dietmar ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c SAN FRANCISCO GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Adherence; HIV AIDS; Indoleamine (2,3) dioxygenase (IDO); Neopterin; Tryptophan

Indexed keywords

COCAINE; KYNURENINE; METHAMPHETAMINE; NEOPTERIN; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRYPTOPHAN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOSTIMULATION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SELF REPORT; VIRUS LOAD;

ADULT; AFFECTIVE SYMPTOMS; ANTI-RETROVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; COCAINE; FEMALE; HIV INFECTIONS; HIV SEROPOSITIVITY; HUMANS; MALE; METHAMPHETAMINE; MIDDLE AGED; NEOPTERIN; PATIENT COMPLIANCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRYPTOPHAN; VIRAL LOAD;

EID: 52949105691     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2008.07.010     Document Type: Article

References (33)

1. Bangsberg D.R., Acosta E.P., Gupta R., Guzman D., Riley E.D., Harrigan P.R., Parkin N., and Deeks S.G. Adherence-resistance relationships for protease inhibitors and non-nucleoside reverse transcriptase inhibitors explained by virological fitness. AIDS 20 (2006) 223-231
2. Beck A.T., Steer R.A., Ball R., and Ranieri W. Comparison of the beck depression inventories-IA and -II in psychiatric outpatients. J. Pers. Assess. 67 (1996) 588-597
3. Carrico, A.W., Chesney, M.A., Johnson, M.O., Neilands, T.B., Remien, R.H., Rotheram-Borus, M.J., Wong, F.L., Healthy Living Project Team, 2008. Randomized controlled trial of a cognitive-behavioral intervention for HIV-positive persons: an investigation of treatment effects on psychosocial adjustment. AIDS Behav. in press, doi:10.1007/s10461-008-9429-6.
4. Carrico A.W., Johnson M.O., Moskowitz J.T., Neilands T.B., Morin S.F., Charlebois E.D., Steward W.T., Remien R.H., Lightfoot M.A., Rotheram-Borus M.J., Wong F.L., and Chesney M.A. Affect regulation, stimulant use, and viral load among HIV-positive persons on anti-retroviral therapy. Psychosom. Med. 69 (2007) 785-792
5. Chesney M.A., Ickovics J.R., Chambers D.B., Gifford A.L., Neidig J., Zwickl B., and Wu A.W. Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient care committee & adherence working group of the outcomes committee of the adult aids clinical trials group (AACTG). AIDS Care 12 (2000) 255-266
6. Cole S.W. Psychosocial influences on HIV-1 disease progression: neural, endocrine, and virologic mechanisms. Psychosom. Med. 70 (2008) 562-568
7. Cole S.W., Korin Y.D., Fahey J.L., and Zack J.A. Norepinephrine accelerates HIV replication via protein kinase A-dependent effects on cytokine production. J. Immunol. 161 (1998) 610-616
8. Cole S.W., Naliboff B.D., Kemeny M.E., Griswold M.P., Fahey J.L., and Zack J.A. Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity. Proc. Natl. Acad. Sci. USA 98 (2001) 12695-12700
9. Ellis R.J., Childers M.E., Cherner M., Lazzaretto D., Letendre S., and Grant I. Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy. J. Infect. Dis. 188 (2003) 1820-1826
10. Fuchs D., Hausen A., Reibnegger G., Schoenitzer D., Unterweger B., Blecha H.G., Hengster P., Roessler H., Schulz T., Werner E.R., Dierich M.P., Hinterhuber H., Schauenstein K., Traill K., and Wachter H. Immune status of drug abusers. Cancer Detect. Prev. Suppl. 1 (1987) 535-541
11. Gan X., Zhang L., Newton T., Chang S.L., Ling W., Kermani V., Berger O., Graves M.C., and Fiala M. Cocaine infusion increases interferon-γ and decreases interleukin-10 in cocaine-dependent subjects. Clin. Immunol. Immunopathol. 89 (1998) 181-190
12. Healthy Living Project Team. Effects of a behavioral intervention to reduce risk of transmission among people living with HIV: the healthy living project randomized controlled study. J. Acquir. Immune Defic. Syndr. 44 (2007) 213-221
13. Hinkin C.H., Barclay T.R., Castellon S.A., Levine A.J., Durvasula R.S., Marion S.D., Myers H.F., and Longshore D. Drug use and medication adherence among HIV-1 infected individuals. AIDS Behav. 11 (2006) 185-194
14. Hunt P.W., Deeks S.G., Bangsberg D.R., Moss A., Sinclair E., Liegler T., Bates M., Tsao G., Lampiris H., Hoh R., and Martin J.N. The independent effect of drug resistance on T cell activation in HIV infection. AIDS 20 (2006) 691-699
15. Irwin M.R., Olmos L., Wang M., Valladares E.M., Motivala S.J., Fong T., Newton T., Butch A., Olmstead R., and Cole S.W. Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanisms. J. Pharmacol. Exp. Ther. 320 (2007) 507-515
16. Johnson M.O., Catz S.L., Remien R.H., Rotheram-Borus M.J., Morin S.F., Charlebois E., Gore-Felton C., Goldsten R.B., Wolfe H., Lightfoot M., and Chesney M.A. Theory-guided, empirically supported avenues for intervention on HIV medication nonadherence: findings from the Healthy Living Project. AIDS Patient Care STDS 17 (2003) 645-656
17. Johnson M.O., Charlebois E., Morin S.F., Remien R.H., and Chesney M.A. Effects of a behavioral intervention on antiretroviral medication adherence among people living with HIV: the healthy living project randomized controlled study. J. Acquir. Immune Defic. Syndr. 46 (2007) 574-580
18. Kobilka B. Adrenergic receptors as models for G protein-coupled receptors. Annu. Rev. Neurosci. 15 (1992) 87-114
19. Kopnisky K.L., Bao J., and Lin Y.W. Neurobiology of HIV, psychiatric and substance abuse comorbidity research: workshop report. Brain Behav. Immun. 21 (2007) 428-441
20. Liang H., Wang X., Chen H., Song L., Ye L., Wang S.H., Wang Y.J., Zhou L., and Ho W.Z. Methamphetamine enhances HIV infection of macrophages. Am. J. Pathol. 172 (2008) 1617-1624
21. Lopez M.C., Lucas L.C., Huang D.S., Yuejian W., and Watson R.R. Modification of thymic cell subsets induced by long-term cocaine administration during murine retroviral infection producing AIDS. Clin. Immunol Immunopathol. 65 (1992) 45-52
22. Makisumi T., Yoshida K., Watanabe T., Tan N., Murakami N., and Morimoto A. Sympatho-adrenal involvement in methamphetamine-induced hyperthermia through skeletal muscle hypermetabolism. Eur. J. Pharmacol. 363 (1998) 107-112
23. Mildvan D., Spritzler J., Grossberg S.E., Fahey J.L., Johnston D.M., Schock B.R., and Kagan J. Serum neopterin, an immune activation marker, independently predicts disease progression in advanced HIV-1 infection. Clin. Infect. Dis. 40 (2005) 853-858
24. Mosser R., and Lesch K.P. Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav. Immun. 12 (1998) 249-271
25. Nance D.W., and Sanders V.M. Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav. Immun. 21 (2007) 736-745
26. Pellegrino T., and Bayer B.M. In vivo effects of cocaine on immune cell function. J. Neuroimmunol. 83 (1998) 139-147
27. Quach L.A., Wanke C.A., Schmid C.H., Gorbach S.L., Mkaya Mwamburi D., Mayer K.H., Spiegelman D., and Tang A.M. Drug use and other risk factors related to lower body mass index among HIV-infected individuals. Drug Alcohol Depend. 95 (2008) 30-36
28. Schroecksnadel K., Wirleitner B., Winkler C., and Fuchs D. Monitoring tryptophan metabolism in chronic immune activation. Clin. Chim. Acta 364 (2006) 82-90
29. Schroecksnadel K., Sarcletti M., Winkler C., Mumelter B., Weiss G., Fuchs D., Kemmler G., and Zangerle R. Quality of life and immune activation in patients with HIV-infection. Brain Behav. Immun. 22 (2008) 881-889
30. Simoni J.M., Kurth A.E., Pearson C.R., Pantalone D.W., Merrill J.O., and Frick P.A. Self-report measures of antiretroviral therapy adherence: a review with recommendations for HIV research and clinical management. AIDS Behav. 10 (2006) 227-245
31. Sloan E.K., Tarara R.P., Capitanio J.P., and Cole S.W. Enhanced replication of simian immunodeficiency virus adjacent to catecholaminergic varicosities in primate lymph nodes. J. Virol. 80 (2006) 4326-4335
32. Widner B., Werner E.R., Schennach H., Wachter H., and Fuchs D. Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin. Chem. 43 (1997) 2424-2426
33. Zangerle R., Widner B., Quirchmair G., Neurauter G., Sarcletti M., and Fuchs D. Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection. Clin. Immunol. 104 (2002) 242-247