Development and in vitro evaluation of a controlled release formulation to produce wide dose interval morphine tablets

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 2, 2008, Pages 544-549

  Holgado, M A ^a   Iruin, A ^a   Alvarez Fuentes, J ^a   Fernandez Arevalo M ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Controlled release tablets; Morphine; pH and ionic strength influences; Polymeric complexes

Indexed keywords

EUDRAGIT; EUDRAGIT L30D; EUDRAGIT RS-PM; MORPHINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG SOLUBILITY; IN VITRO STUDY; IONIC STRENGTH; PH; TABLET;

CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; HYDROGEN-ION CONCENTRATION; MORPHINE; OSMOLAR CONCENTRATION; SOLUBILITY; TABLETS;

EID: 52949104478     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.05.021     Document Type: Article

References (18)

1. Amabile C.M., and Bowman B.J. Overview of oral modified-release opioid products for the management of chronic pain. Ann. Pharmacother. 40 (2006) 1327-1335
2. P.J. Wiffen, J.E. Edwards, J. Barden, H.J.M. McQuay, Oral morphine for cancer pain, http://www.cochrane.org (2006).
3. Caldwell J.R. Avinza-24 h sustained-release oral morphine therapy. Expert Opin. Pharmacother. 5 (2004) 469-472
4. A.M. Rabasco, M. Fernández-Arévalo, J. Alvarez-Fuentes, M.A. Holgado, I. Caraballo, Sistema de liberación controlada de morfina y otros fármacos solubles en agua por complejación con sustancias poliméricas. Spanish patent P9401748, University of Seville (1994).
5. Alvarez-Fuentes J., Fernández-Arévalo M., Holgado M.A., Caraballo I., Llera J.M., and Rabasco A.M. Morphine polymeric coprecipitates for controlled release: elaboration and characterization. Drug Dev. Ind. Pharm. 20 (1994) 2409-2424
6. Alvarez-Fuentes J., Fernández-Arévalo M., Holgado M.A., Caraballo I., Llera J.M., and Rabasco A.M. Characterization of morphine polymeric coprecipitates: a biopharmaceutical study. Pharmazie 49 (1994) 834-839
7. Alvarez-Fuentes J., Fernández-Arévalo M., Holgado M.A., Caraballo I., and Rabasco A.M. Influence of the pH value of the dissolution medium on the release profiles of a morphine polymeric complex. Drug Dev. Ind. Pharm. 23 (1997) 553-559
8. Alvarez-Fuentes J., Fernández-Arévalo M., Holgado M.A., Caraballo I., Rabasco A.M., Micó J.A., Rojas O., and Ortega-Alvaro A. Preclinical study of a controlled release oral morphine system in rats. Int. J. Pharm. 139 (1996) 237-241
9. Fernández-Arévalo M., Caraballo I., Millán M., Holgado M.A., Sánchez-Lafuente C., Rabasco A.M., and Alvarez-Fuentes J. Optimisation of a complexation process as a new method for obtaining a controlled morphine delivery system. STP Pharm. Sci. 12 (2002) 334-336
10. Fernández-Arévalo M., Alvarez-Fuentes J., Iruin A., and Holgado M.A. In vitro evaluation of a morphine polymeric complex: flowability behaviour and dissolution study. AAPS Pharm. Sci. Tech. 5 (2004) article 39
11. http://www.cancer-pain.org/treatments (2006).
12. M. Fernandez-Arévalo, J. Alvarez-Fuentes, M. Millán, M.A. Holgado, I. Caraballo, J.E. Peris, A.M. Rabasco, Medicamentos de liberación controlada de morfina, basados en un complejo de morfina con polímeros acrílicos. Spanish patent P200201927, University of Seville (2002).
13. Monferoni M.C., Rossi S., Ferrari F., Stavik E., Pena-Romero A., and Caramella C. Factorial analysis of the influence of dissolution medium on drug release from carragenan-diltiazem complexes. AAPS Pharm. Sci. Tech. 2 (2000) article 15
14. Korsmeyer R.W., Gurny R., Doelker E., Buri P., and Peppas N.A. Mechanism of solute release from porous hydrophilic polymers. Int. J. Pharm. 15 (1983) 25-35
15. ® RS-PM matrices. Int. J. Pharm. 170 (1998) 169-177
16. Caraballo I., Melgoza L.M., Álvarez-Fuentes J., Soriano M.C., and Rabasco A.M. Desing of controlled release inert matrices of naltrexone hydrochloride based on percolation concepts. Int. J. Pharm. 181 (1999) 23-30
17. Melgoza L.M., Rabasco A.M., Sandoval H., and Caraballo I. Estimation of the percolation thresholds in dextromethorphan hydrobromide matrices. Eur. J. Pharm. Sci. 12 (2001) 453-459
18. http://www.sedolor.es/2001ponencia (2006).