Leptin, ghrelin, and adiponectin evaluation in transsexual subjects during hormonal treatments

Journal of Andrology

Volumn 29, Issue 5, 2008, Pages 580-585

  Resmini, Eugenia ^a   Andraghetti, Gabriella ^a   Rebora, Alberto ^a   Cordera, Renzo ^a   Vera, Lara ^a   Giusti, Massimo ^a   Minuto, Francesco ^a   Ferone, Diego ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Cardiovascular risk; Metabolic parameters; Sexual hormones

Indexed keywords

ADIPONECTIN; CYPROTERONE ACETATE; ESTRADIOL; GHRELIN; LEPTIN; SEX HORMONE; SPIRONOLACTONE; TESTOSTERONE; TESTOSTERONE ENANTATE; TESTOSTERONE PHENYLPROPIONATE; TESTOSTERONE PROPIONATE;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; FEMALE; FEMALE TO MALE TRANSSEXUAL; HORMONAL THERAPY; HORMONE DETERMINATION; HUMAN; MALE; MALE TO FEMALE TRANSSEXUAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; TRANSSEXUALISM;

ADIPONECTIN; ADULT; BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; GHRELIN; GONADAL STEROID HORMONES; HUMANS; LEPTIN; MALE; SEX CHARACTERISTICS; TRANSSEXUALISM;

EID: 52949104370     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.108.004952     Document Type: Article

References (30)

1. Barkan AL, Dimaraki EV, Jessup SK, Symons KV, Ermolenko M, Jaffe CA. Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. J Clin Endocrinol Metab. 2003;88:2180-2184.
2. Berra M, Armillotta F, D'Emidio L, Costantino A, Martorana G, Pelusi G, Meriggiola MC. Testosterone decreases adiponectin levels in female to male transsexuals. Asian J Androl. 2006;8:725-729.
3. Bottner A, Kratzsch J, Muller G, Kapellen TM, Bluher S, Keller E, Bluher M, Kiess W. Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab. 2004;89:4053-4061.
4. Casabiell X, Pineiro V, Vega F, De La Cruz LF, Dieguez C, Casanueva FF. Leptin, reproduction and sex steroids. Pituitary. 2001;4:93-99.
5. Castrogiovanni D, Perello M, Gaillard RC, Spinedi E. Modulatory role of testosterone in plasma leptin turnover in rats. Endocrine. 2003;22:203-210.
6. Chu MC, Cosper P, Orio F, Carmina E, Lobo RA. Insulin resistance in postmenopausal women with metabolic syndrome and the measurements of adiponectin, leptin, resistin, and ghrelin. Am J Obstet Gynecol. 2006;194:100-104.
7. Dunajska K, Milewicz A, Jedrzejuk D, Szymczak J, Kuliczkowski W, Salomon P, Bialy D, Poczatek K, Nowicki P. Plasma adiponectin concentration in relation to severity of coronary atherosclerosis and cardiovascular risk factors in middle-aged men. Endocrine. 2004;25:215-221.
8. Eckardstein A, Wu FC. Testosterone and atherosclerosis. Growth Horm IGF Res. 2003;13:72-84.
9. Elbers JM, Asscheman H, Seidell JC, Frölich M, Meinders AE, Gooren LJ. Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals. J Clin Endocrinol Metab. 1997;82:3267-3270.
10. Elbers JM, Giltay EJ, Teerlink T, Scheffer PG, Asscheman H, Seidell JC, Gooren LJ. Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects. Clin Endocrinol. 2003;58:562-571.
11. Gambineri A, Pagotto U, De Lasio R, Meriggiola MC, Costantino A, Patton L, Pelusi C, Pelusi G, Pasquali R. Short-term modification of sex hormones is associated with changes in ghrelin circulating levels in healthy normal-weight men. J Endocrinol Invest. 2005; 28:241-246.
12. Gambineri A, Pagotto U, Tschop M, Vicennati V, Manicardi E, Carcello A, Cacciari M, De Iasio R, Pasquali R. Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome. J Endocrinol Invest. 2003;26:629-634.
13. Giannessi D, Maltinti M, Del Ry S. Adiponectin circulating levels: a new emerging biomarker of cardiovascular risk. Pharmacol Res. 2007;56:459-467.
14. Gooren LJ, Giltay EJ, Bunck MC J. Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience. J Clin Endocrinol Metab. 2008;93:19-25.
15. Greenman Y, Golani N, Gilad S, Yaron M, Limor R, Stern N. Ghrelin secretion is modulated in a nutrient- and gender-specific manner. Clin Endocrinol. 2004;60:382-388.
16. Gulcelik NE, Aral Y, Serter R, Koc G. Association of hypoadiponectinemia with metabolic syndrome in patients with polycystic ovary syndrome. J Natl Med Assoc. 2008 Jan;100:64-68.
17. Hislop MS, Ratanjee BD, Soule SG, Marais AD. Effects of anabolic-androgenic steroid use or gonadal testosterone suppression on serum leptin concentration in men. Eur J Endocrinol. 1999;141: 40-46.
18. Kellokoski E, Poykko SM, Karjalainen AH, Ukkola O, Heikkinen J, Kesaniemi YA, Horkko S. Estrogen replacement therapy increases plasma ghrelin levels. J Clin Endocrinol Metab. 2005;90:2954-2963.
19. Laughlin GA, Barrett-Connor E, May S. Sex-specific association of the androgen to oestrogen ratio with adipocytokine levels in older adults: the Rancho Bernardo Study. Clin Endocrinol. 2006;65: 506-513.
20. Laughlin GA, Barrett-Connor E, May S. Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones. Int J Obes. 2007;31:457-465.
21. Martin LJ, Mahaney MC, Almasy L, MacCluer JW, Blangero J, Jaquish CE, Comuzzie AG. Leptin's sexual dimorphism results from genotype by sex interactions mediated by testosterone. Obes Res. 2002;10:14-21.
22. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419.
23. Nishizawa H, Shimomura I, Kishida K, Maeda N, Kuriyama H, Nagaretani H, Matsuda M, Kondo H, Furuyama N, Kihara S, Nakamura T, Tochino Y, Funahashi T, Matsuzawa Y. Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes. 2002;51:2734-2741.
24. Page ST, Herbst KL, Amory JK, Coviello AD, Anawalt BD, Matsumoto AM, Bremner WJ. Testosterone administration suppresses adiponectin levels in men. J Androl. 2005;26:85-92.
25. Pagotto U, Gambineri A, Pelusi C, Genghini S, Cacciari M, Otto B, Castaneda T, Tschop M, Panidis D, Farmakiotis D, Koliakos G, Rousso D, Kourtis A, Katsikis I, Asteriadis C, Karayannis V, Diamanti-Kandarakis E. Comparative study of plasma ghrelin levels in women with polycystic ovary syndrome, in hyperandrogenic women and in normal controls. Hum Reprod. 2005;20:2127-2132.
26. Pardo IM, Geloneze B, Tambascia MA, Pereira JL, Barros Filho AA. Leptin as a marker of sexual dimorphism in newborn infants. J Pediatr. 2004;80:305-308.
27. Pasquali R. Testosterone replacement therapy restores normal ghrelin in hypogonadal men. J Clin Endocrinol Metab. 2003;88:4139-4143.
28. Rosenbaum M, Pietrobelli A, Vasselli JR, Heymsfield SB, Leibel RL. Sexual dimorphism in circulating leptin concentrations is not accounted for by differences in adipose tissue distribution. Int J Obes Relat Metab Disord. 2001;25:1365-1371.
29. Saad MF, Damani S, Gingerich RL, Riad-Gabriel MG, Khan A, Boyadjian R, Jinagouda SD, el-Tawil K, Rude RK, Kamdar V. Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab. 1997;82:579-584.
30. Seftel AD. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Urol. 2005;174:1045-1046.