Prognostic significance of hepatocyte growth factor and microvessel bone marrow density in patients with chronic myeloid leukaemia

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 68, Issue 6, 2008, Pages 492-500

  Zhelyazkova, A G ^a   Tonchev, A B ^a   Kolova, P ^a   Ivanova, L ^a   Gercheva, L ^a  

^a UNIVERSITY HOSPITAL ST MARINA   (Bulgaria)

Author keywords

Angiogenesis; Chronic myeloid leukaemia; HGF; VEGF

Indexed keywords

LACTATE DEHYDROGENASE; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ADULT; AGED; ANGIOGENESIS; ARTICLE; BLAST CELL; BONE DENSITY; BONE MARROW; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOHISTOCHEMISTRY; LEUKOCYTE; MICROVASCULATURE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SPLENOMEGALY; TUMOR VOLUME;

ADOLESCENT; ADULT; AGED; BONE MARROW; BONE MARROW CELLS; CELL COUNT; HEPATOCYTE GROWTH FACTOR; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MICROVESSELS; MIDDLE AGED; PROGNOSIS; PROTO-ONCOGENE PROTEINS; RECEPTORS, GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 52949103618     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510701854991     Document Type: Article

References (38)

1. Rowley JD. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973;243:290-3.
2. De Klein A, Van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature 1982;300:765-7.
3. Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 2002;100:2292-302.
4. Gordon MY, Dowding CR, Riley GP, Goldman JM, Greaves MF. Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia. Nature 1987;328:342-4.
5. Folkman J. The role of angiogenesis in tumor growth. Semin Cancer Biol 1992;3:65-71.
6. Vacca A, Ribatti D, Presta M, Minischetti M, Iurlaro M, Ria R, et al. Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood 1999;93:3064-73.
7. Pádro T, Ruiz S, Bieker R, Bürger H, Steins M, Kienast J, et al. Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia. Blood 2000;95:2637-44.
8. Molica S, Vacca A, Ribatti D, Cuneo A, Cavazzini F, Levato D, et al. Prognostic value of enhanced bone marrow angiogenesis in early B-cell chronic lymphocytic leukemia. Blood 2002;100:3344-51.
9. Salven P. Angiogenesis in lymphoproliferative disorders. Acta Haematol 2001;106:184-9.
10. Lundberg LG, Lerner R, Sundelin P, Rogers R, Folkman J, Palmblad J. Bone marrow in polycythemia vera, chronic myelocytic leukemia, and myelofibrosis has an increased vascularity. Am J Pathol 2000;157:15-19.
11. Palmblad J, Lerner R, Lundberg LG. Vascular density, intracellular VEGF and bFGF positivity as prognostic factors in polycythemia vera and chronic myelocytic leukemia. Blood 2000;96:257b.
12. Aguayo A, Kantarjian H, Manshouri T, Gidel C, Estey E, Thomas D, et al. Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. Blood 2000;96:2240-5.
13. Krauth MT, Simonitsch I, Mayerhofer M, Sperr WR, Sillaber C, Schneeweiss B, et al. Immunohistochemical detection of VEGF in the bone marrow of patients with chronic myeloid leukemia and correlation with phase of disease. Am J Clin Pathol 2004;121:473-81.
14. Verstovsek S, Lunin S, Kantarjian H, Manshouri T, Faderl S, Cortes J, et al. Clinical relevance of VEGF receptors 1 and 2 in patients with chronic myelogenous leukemia. Leuk Res 2003;27:661-9.
15. Di Raimundo F, Fichera E, Azzaro MP, Stagno F, Palumbo GA. Low serum levels of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in IFN-treated chronic myeloid leukemia (CML) patients. Blood 2000;96:253b.
16. Di Raimondo F, Palumbo GA, Molica S, Guistolisi R. Angiogenesis in chronic myeloproliferative disorders. Acta Haematol 2001;106:177-83.
17. Janowska-Wieczorek A, Majka M, Marquez-Curtis L, Wertheim JA, Turner AR, Ratajczak MZ. Bcr-abl-positive cells secrete angiogenic factors including matrix metalloproteinases and stimulate angiogenesis in vivo in Matrigel implants. Leukemia 2002;6:1160-6.
18. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-9.
19. Shibuya M. Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Structure Function 2001;26:25-35.
20. Dias S, Shmelkov SV, Lam G, Rafii S. VEGF165 promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood 2000;99:2532-40.
21. Fiedler W, Graeven U, Ergun S, Verago S, Kilic N, Stockschlader M, et al. Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. Blood 1997;89:1870-5.
22. Bellamy WT, Richter L, Sirjani D, Roxas C, Glinsmann-Gibson B, Frutiger Y, et al. Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes. Blood 2001;97:1427-34.
23. Bellamy WT, Richter L, Frutiger Y, Grogan TM. Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies. Cancer Research 1999;59:728-33.
24. Mayerhofer M, Valent P, Sperr WR, Griffin JD, Sillaber C. BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood 2002;100:3767-75.
25. Nakamura T, Teramoto H, Ichihara A. Purification and characterization of a growth factor from rat platelets for mature parenchimal hepatocytes in primary cultures. Proc Natl Acad Sci 1986;83:6489-93.
26. Stoker M, Gherardi E, Perryman M, Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell motility. Nature 1987;327:239-42.
27. Kmiecik TE, Keller JR, Rosen E, Vande Woude GF. Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells. Blood 1992;80:2454-7.
28. Miyazawa K, Tsubouchi H, Naka D, Iakahashi K, Okigaki M, Arakaki N, et al. Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem Biophys Res Commun 1989;163:967-73.
29. Naldini L, Weidner KM, Vigna E, Sachs M, Gaudino G, Bardelli A, et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the Met receptor. EMBO J 1991;10:2867-78.
30. Jiang W, Hiscox S, Matsumoto K, Nakamura T. Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer. Crit Rev Oncol Hematol 1999;29:209-48.
31. Pons E, Uphoff CC, Drexler HG. Expression of hepatocyte growth factor and its receptor c-met in human leukemialymphoma cell lines. Leuk Res 1998;22:797-804.
32. Hino M, Inaba M, Goto H, Nishizawa Y, Tatsumi N, Nishino T, et al. Hepatocyte growth factor levels in bone marrow plasma of patients with leukaemia and its gene expression in leukaemic blast cells. Br J Cancer 1996;73:119-23.
33. Gwang Kim J, Kyun Sohn S, Hwan Kim D, Ho Baek J, Young Lee N, Soo Suh J, et al. Clinical implications of angiogenic factors in patients with acute or chronic leukemia: hepatocyte growth factor levels have prognostic impact, especially in patients with acute myeloid leukemia. Leuk Lymph 2005;46:885-91.
34. Weimar IS, Voermans C, Bourhis JH, Miranda N, Van den Berk PCM, Nakamura T, et al. Hepatocyte growth factor/scatter factor (HGF/SF) affects proliferation and migration of myeloid leukemic cells. Leukemia 1998;12:1195-203.
35. Verstovsek S, Kantarjian H, Manshouri T, Cortes J, Giles FJ, Rogers A, et al. Prognostic significance of cellular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia. Blood 2002;99:2265-7.
36. Mohle R, Green D, Moore MA, Nachman RL, Rafii S. Constitutive production and thrombin induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc Natl Acad Sci USA 1997;94:663-8.
37. Guo-Rui Ruan, Yan-Rong Liu, Shan-Shan Chen, Jia-Yu Fu, Yan Chang, Ya-Zhen Qin, et al. Effect of antisense VEGF cDNA transfection on the growth of chronic myeloid leukemia K562 cells in vitro and in nude mice. Leuk Res 2004;28:763-9.
38. Korkolopoulou P, Viniou N, Kavantzas N, et al. Clinicopathologic correlations of bone marrow angiogenesis in chronic myeloid leukemia: a morphometric study. Leukemia 2003;17:89-97.