enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1

Drug Metabolism and Disposition

Volumn 36, Issue 10, 2008, Pages 2080-2085

  Nishimura, Tomohiro ^a   Seki, Yoshiaki ^a   Sato, Kazuko ^a   Chishu, Takuya ^a   Kose, Noriko ^a   Terasaki, Tetsuya ^b,c   Kang, Young Sook ^d   Sai, Yoshimichi ^a   Nakashima, Emi ^a  

^a KEIO UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d Sookmyung Women's University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; PRASTERONE SULFATE; ZIDOVUDINE;

ANIMAL CELL; ARTICLE; BLOOD PLACENTA BARRIER; CELL LINE; CONTROLLED STUDY; DRUG TRANSPORT; DRUG UPTAKE; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MICHAELIS CONSTANT; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; RAT; SYNCYTIOTROPHOBLAST; VIRUS TRANSMISSION;

ANIMALS; CELL LINE; DEHYDROEPIANDROSTERONE SULFATE; DRUG INTERACTIONS; MODELS, THEORETICAL; RATS; REVERSE TRANSCRIPTASE INHIBITORS; THYMIDINE; TROPHOBLASTS; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS 1; RATTUS;

EID: 52949097941     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.021345     Document Type: Article

References (26)

1. Antonelli G, Turriziani O, Cianfriglia M, Riva E, Dong G, Fattorossi A, and Dianzani F (1992) Resistance of HIV-1 to AZT might also involve the cellular expression of multidrug resistance P-glycoprotein. AIDS Res Hum Retroviruses 8:1839-1844.
2. Chen R and Nelson JA (2000) Role of organic cation transporters in the renal secretion of nucleosides. Biochem Pharmacol 60:215-219.
3. Chen ZS, Guo Y, Belinsky MG, Kotova E, and Kruh GD (2005) Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol 67:545-557.
4. Chishu T, Sai Y, Nishimura T, Sato K, Kose N, and Nakashima E (2008) Potential of various drugs to inhibit nucleoside uptake in rat syncytiotrophoblast cell line, TR-TBT 18d-1. Placenta 29:461-467.
5. Dancis J, Lee J, Mendoza S, and Liebes L (1993) Nucleoside transport by perfused human placenta. Placenta 14:547-554.
6. Grube M, Köck K, Karner S, Reuther S, Ritter CA, Jedlitschky G, and Kroemer HK (2006) Modification of OATP2B1-mediated transport by steroid hormones. Mol Pharmacol 70:1735-1741.
7. Grube M, Reuther S, Meyer Zu Schwabedissen H, Köck K, Draber K, Ritter CA, Fusch C, Jedlitschky G, and Kroemer HK (2007) Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta. Drug Metab Dispos 35:30-35.
8. Hasegawa M, Kusuhara H, Endou H, and Sugiyama Y (2003) Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat. J Pharmacol Exp Ther 305:1087-1097.
9. Kitano T, Iizasa H, Hwang IW, Hirose Y, Morita T, Maeda T, and Nakashima E (2004) Conditionally immortalized syncytiotrophoblast cell lines as new tools for study of the blood-placenta barrier. Biol Pharm Bull 27:753-759.
10. Kitano T, Iizasa H, Terasaki T, Asashima T, Matsunaga N, Utoguchi N, Watanabe Y, Obinata M, Ueda M, and Nakashima E (2002) Polarized glucose transporters and mRNA expression properties in newly developed rat syncytiotrophoblast cell lines, TR-TBTs. J Cell Physiol 193:208-218.
11. Morissette M, Dicko A, Pézolet M, Callier S, and Di Paolo T (1999) Effect of dehydroepiandrosterone and its sulfate and fatty acid ester derivatives on rat brain membranes. Steroids 64:796-803.
12. Morita N, Kusuhara H, Sekine T, Endou H, and Sugiyama Y (2001) Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. J Pharmacol Exp Ther 298:1179-1184.
13. Pan G, Giri N, and Elmquist WF (2007) Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine. Drug Metab Dispos 35:1165-1173.
14. Plager JE (1965) The binding of androsterone sulfate, etiocholanolone sulfate, and dehydro-isoandrosterone sulfate by human plasma protein. J Clin Invest 44:1234-1239.
15. +- nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J Biol Chem 276:2914-2927.
16. Sai Y, Nishimura T, Shimpo S, Chishu T, Sato K, Kose N, Terasaki T, Mukai C, Kitagaki S, Miyakoshi N, et al. (2008) Characterization of the mechanism of zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT. Pharm Res 25:1647-1653.
17. Schuetz JD, Connelly MC, Sun D, Paibir SG, Flynn PM, Srinivas RV, Kumar A, and Fridland A (1999) MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med 5:1048-1051.
18. Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, and Endou H (2002) Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther 300:918-924.
19. Takeuchi A, Masuda S, Saito H, Abe T, and Inui K (2001) Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2. J Pharmacol Exp Ther 299:261-267.
20. Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, and Tsuji A (2001) Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharm Res 18:1262-1269.
21. Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, and Endou H (2000) Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther 294:844-849.
22. Wang X, Nitanda T, Shi M, Okamoto M, Furukawa T, Sugimoto Y, Akiyama S, and Baba M (2004) Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein. Biochem Pharmacol 68:1363-1370.
23. Yao SY, Cass CE, and Young JD (1996) Transport of the antiviral nucleoside analogs 3′-azido-3′-deoxythymidine and 2′,3′-dideoxycytidine by a recombinant nucleoside transporter (rCNT) expressed in Xenopus laevis oocytes. Mol Pharmacol 50:388-393.
24. Yao SY, Ng AM, Sundaram M, Cass CE, Baldwin SA, and Young JD (2001) Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzyl- thioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol Membr Biol 18:161-167.
25. Yamaoka K, Tanigawara Y, Nakagawa T, and Uno T (1981) A pharmacokinetic analysis program (multi) for microcomputer. J Pharmacodyn 4:879-885.
26. Zhou F, Tanaka K, Soares MJ, and You G (2003) Characterization of an organic anion transport system in a placental cell line. Am J Physiol Endocrinol Metab 285:E1103-E1109.