Oral toxicity of p-aminopropiophenone to brushtail possums (Trichosurus vulpecula), dama wallabies (macropus Eugenii), and mallards (Anas platyrhynchos)

Journal of Wildlife Diseases

Volumn 44, Issue 3, 2008, Pages 655-663

  Fisher, P ^a   O'Connor, C E ^b   Morriss, G ^a  

^a LANDCARE RESEARCH   (New Zealand)

^b Ministry for Primary Industries   (New Zealand)

Author keywords

Duck; Marsupial; Nontarget; P aminopropiophenone; PAPP; Possum; Toxicity; Wallaby

Indexed keywords

ANAS; ANAS PLATYRHYNCHOS; AVES; DAMA; EUTHERIA; MACROPODIDAE; MACROPUS EUGENII; METATHERIA; PHALANGERIDAE; TRICHOSURUS; TRICHOSURUS VULPECULA; VERTEBRATA;

EID: 52949090438     PISSN: 00903558     EISSN: None     Source Type: Journal    
DOI: 10.7589/0090-3558-44.3.655     Document Type: Article

References (33)

1. BAKER, M. L., P. J. CANFIELD, AND R. T. GEMMEL. 1995. Erythrocyte metabolism in the koala, the common brushtail possum and the whiptail wallaby. Comparative Haematology International 6: 225-231.
2. BARTLET, A. L., AND L. M. KIRINYA. 1976. Activities of mixed function oxidases, UDP-glucuronyl transferase and sulphate conjugation enzymes in galliformes and anseriformes. Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 61: 105-119.
3. BLAAUBOER, B. J., C. W. VAN HOLSTEIJN, AND J. G. WIT. 1979. Biochemical processes involved in ferri-hemoglobin formation by monohydroxyaniline derivatives in erythrocytes of birds and mammals. Comparative Biochemistry and Physiology C 62: 199-203.
4. BLAAUBOER, B. J., C. W. VAN HOLSTEIJN, AND J. G. WIT. 1980. Effects of phenylhydroxylamine and aminophenols in Japanese quail in vivo. Xenobiotica 10: 495-498.
5. BOARD, P. G., N. S. AGAR, M. GRUCA, AND R. SHINE. 1977. Methaemoglobin and its reduction in nucleated erythrocytes from reptiles and birds. Comparative Biochemistry and Physiology B 57: 265-267.
6. COLEMAN, I. W., P. E. LITTLE, AND G. A. GRANT. 1960. The induction of methemoglobinemia as an adjunct to therapy for tabun poisoning. Canadian Journal of Biochemistry and Physiology 38: 667-672.
7. COLEMAN, M. D., AND N. A. COLEMAN. 1996. Drug-induced methaemoglobinaemia: Treatment issues. Drug Safety 14: 394-405.
8. COURT, M. H. 2001. Acetaminophen UDP-glucuronosyltransferase in ferrets: Species and gender differences, and sequence analysis of ferret UGT1A6. Journal of Veterinary Pharmacology and Therapeutics 24: 415-422.
9. COURT, M. H., AND D. J. GREENBLATT. 1997. Biochemical basis for deficient paracetamol glucuronidation in cats: An interspecies comparison of enzyme constraint in liver microsomes. Journal of Pharmacy and Pharmacology 49: 446-449.
10. DASH, J. A. 1988. Effect of dietary terpenes on glucuronic acid excretion and ascorbic acid turnover in the brushtail possum ( Trichosurus vulpecula). Comparative Biochemistry and Physiology B 89: 221-226.
11. EL MEKAWI, S., R. YAGIL, AND N. MEYERSTEIN. 1993. Effect of oxidative stress on avian erythrocytes. Journal of Basic and Clinical Physiology and Pharmacology 4 3: 199-211.
12. FISHER, P., AND C. O'CONNER. 2007. Oral toxicity of p-aminopropiophenone to ferrets. Wildlife Research 31 4: 19-24.
13. FISHER, P., C. O'CONNER, AND E. MURPHY. 2005. Acute oral toxicity of p-aminopropiophenone to stoats (Mustela erminea). New Zealand Journal of Zoology 32: 163-169.
14. FLEMING, P. J. S., L. R. ALLEN, S. J. LAPIDGE, A. ROBLEY, G. R. SAUNDERS, AND P. C. THOMSON. 2006. A strategic approach to mitigating the impacts of wild canids: Proposed activities of the Invasive Animals Cooperative Research Centre. Australian Journal of Experimental Agriculture 46: 753-762.
15. GRAFFE, W., M. KIESE, AND E. RAUSCHER. 1964. The formation in vivo of p-hydroxlaminopropriophenone and p-aminopropiophenone and its action in vivo and in vitro. Naunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie 249: 168-175.
16. HARVEY, J. W. 1989. Erythrocyte metabolism. In Clinical biochemistry of domestic animals, 4th Edition. Academic Press, New York, New York, pp. 185-234.
17. MARINO, M. T., M. R. URQUHART, M. L. SPERRY, J. V. BREDOW, L. D. BROWN, E. LIN, AND T. G. BREWER. 1997. Pharmacokinetics and kinetic-dynamic modelling of aminophenones as methaemoglobin formers. Journal of Pharmacy and Pharmacology 49: 282-287.
18. MARKS, C. A., F. GIGLIOTTI, F. BUSANA, M. JOHNSTON, AND M. LINDEMAN . 2004. Fox control using a para-aminopropiophenone formulation with the M-44 ejector. Animal Welfare 13: 401-407.
19. MARRS, T. C., AND J. E. BRIGHT. 1987. Effect on blood and plasma cyanide levels and on methaemoglobin levels of cyanide administered with and without previous protection using PAPP. Human Toxicology 6: 139-145.
20. MARRS, T. C., R. H. INNS, J. E. BRIGHT, AND S. G. WOOD. 1991. The formation of methaemoglobin by 4-aminopropiophenone (PAPP) and 4-(N-hydroxy) aminopropiophenone. Human and Experimental Toxicology 10: 183-188.
21. MCLEAN, S., S. BRANDON, N. W. DAVIES, R. BOYLE, W. J. FOLEY, B. MOORE, AND G. J. PASS. 2003. Glucuronuria in the koala. Journal of Chemical Ecology 29: 1465-1477.
22. MURPHY, E. C., A. LAVRENT, D. MACMORRAN, L. ROBBINS, AND P. ROSS . 2005. Development of a humane toxin for the control of introduced mammalian predators in New Zealand. In Proceedings of the 13th Australasian Vertebrate Pest Conference, Wellington, New Zealand, 2-5 May, pp. 137-142.
23. OGAWA, E., S. S. O'CALLAGHAN, AND N. S. AGAR. 1998. Methaemoglobin formation in the koala and the possum. Comparative Haematology International 8: 171-173.
24. PAN, H. P., P. J. SAVARIE, D. J. ELIAS, AND R. R. FELTON. 1983. Alkyl chain length and acute oral toxicity of p-aminophenones. General Pharmacology 14: 465-467.
25. ROCKWOOD, G. A., K. R. ARMSTRONG, AND S. I. BASKIN. 2003. Species comparison of methemoglobin reductase. Experimental Biology and Medicine 228: 79-83.
26. SAVARIE, P. J., H. P. PAN, D. J. HAYES, J. D. ROBERTS, G. J. DASCH, R. FELTON, AND E. W. SCHAFER, JR. 1983. Comparative acute oral toxicity of paraaminopropriophenone (PAPP) in mammals and birds. Bulletin of Environmental Contamination and Toxicology 30: 122-126.
27. SCAWIN, J. W., D. W. SWANSTON, AND T. C. MARRS. 1984. The acute oral and intravenous toxicity of p-aminopropiophenone (PAPP) to laboratory rodents. Toxicology Letters 23: 359-365.
28. SHORT, C. R., W. FLORY, L. C. HSIEH, T. ARANAS, S. P. OU, AND J. WEISSINGER. 1988. Comparison of hepatic drug metabolizing enzyme activities in several agricultural species. Comparative Biochemistry and Physiology C 91: 419-424.
29. SMITH, R. P. 1969. The significance of methemoglobinemia in toxicology. In Essays in toxicology, F. R. Blood (ed.). Academic Press, New York, New York, pp. 83-113.
30. TEPPERMAN, J., AND O. BODANSKY. 1946. The role of hepatic detoxification in p-aminopropiophenone induced methemoglobinemia. American Society for Pharmacology and Experimental Therapeutics 88: 287-299.
31. VON JAGOW, R., M. KIESE, AND G. RENNER. 1966. Urinary excretion of N-hydroxy derivatives of some aromatic amines by rabbits, guinea pigs and dogs. Biochemical Pharmacology 15: 1899-1910.
32. WHITTINGTON, A. T., A. L. PARKINSON, AND P. B. S. SPENCER. 1995. Comparative study of the antioxidant defence systems in the erythrocytes of Australian marsupials and monotremes. Comparative Biochemistry and Physiology C 110: 267-272.
33. WOOD, S. G., K. FITZPATRICK, J. E. BRIGHT, R. H. INNS, AND T. C. MARRS. 1991. Studies of the pharmacokinetics and metabolism of 4-aminopropiophenone (PAPP) in rats, dogs and cynomolgus monkeys. Human and Experimental Toxicology 10: 365-374.