Cortical processing of respiratory occlusion stimuli in children with central hypoventilation syndrome

American Journal of Respiratory and Critical Care Medicine

Volumn 178, Issue 7, 2008, Pages 757-764

  Huang, Jingtao ^a   Marcus, Carole L ^a,b   Bandla, Preetam ^a   Schwartz, Michael S ^a   Pepe, Michelle E ^a   Samuel, John M ^a   Panitch, Howard B ^a,b   Bradford, Ruth M ^a   Mosse, Yael P ^a   Maris, John M ^a,b   Colrain, Ian M ^c,d  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c SRI INTERNATIONAL   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Central hypoventilation syndrome; Respiratory related evoked potentials; Sleep; Wakefulness

Indexed keywords

ADOLESCENT; ADULT; AIRWAY PRESSURE; ARTICLE; ARTIFICIAL VENTILATION; CENTRAL HYPOVENTILATION SYNDROME; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; EVOKED CORTICAL RESPONSE; FACE MASK; FEMALE; HUMAN; LUNG ALVEOLUS HYPOVENTILATION; MALE; MECHANICAL STIMULATION; PRIORITY JOURNAL; REM SLEEP; SCHOOL CHILD; SLOW WAVE SLEEP; UPPER RESPIRATORY TRACT OBSTRUCTION; WAKEFULNESS; CASE CONTROL STUDY; CENTRAL SLEEP APNEA SYNDROME; CHILD; ELECTROENCEPHALOGRAPHY; EVOKED SOMATOSENSORY RESPONSE; LUNG FUNCTION TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYSOMNOGRAPHY; PRESCHOOL CHILD;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, SOMATOSENSORY; FEMALE; HUMANS; MALE; POLYSOMNOGRAPHY; RESPIRATORY FUNCTION TESTS; SLEEP APNEA, CENTRAL; SLEEP, REM; WAKEFULNESS;

EID: 52749089851     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200804-606OC     Document Type: Article

References (50)

1. Ize-Ludlow D, Gray JA, Sperling MA, Berry-Kravis EM, Milunsky JM, Farooqi IS, Rand CM, Weese-Mayer DE. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood. Pediatrics 2007;120:e179-e188.
2. Katz ES, McGrath S, Marcus CL. Late-onset central hypoventilation with hypothalamic dysfunction: a distinct clinical syndrome. Pediatr Pulmonol 2000;29:62-68.
3. American Thoracic Society. Idiopathic congenital central hypoventilation syndrome: diagnosis and management. Am J Respir Crit Care Med 1999;160:368-373.
4. Davenport PW, Friedman WA, Thompson FJ, Franzen O. Respiratory-related cortical potentials evoked by inspiratory occlusion in humans. J Appl Physiol 1986;60:1843-1848.
5. Gozal D, Simakajornboon N. Passive motion of the extremities modifies alveolar ventilation during sleep in patients with congenital central hypoventilation syndrome. Am J Respir Crit Care Med 2000;162:1747-1751.
6. Macey KE, Macey PM, Woo MA, Harper RK, Alger JR, Keens TG, Harper RM. FMRI signal changes in response to forced expiratory loading in congenital central hypoventilation syndrome. J Appl Physiol 2004;97:1897-1907.
7. Marcus CL, Bautista DB, Amihyia A, Ward SL, Keens TG. Hypercapneic arousal responses in children with congenital central hypoventilation syndrome. Pediatrics 1991;88:993-998.
8. Gozal D, Marcus CL, Shoseyov D, Keens TG. Peripheral chemoreceptor function in children with the congenital central hypoventilation syndrome. J Appl Physiol 1993;74:379-387.
9. Paton JY, Swaminathan S, Sargent CW, Keens TG. Hypoxic and hypercapnic ventilatory responses in awake children with congenital central hypoventilation syndrome. Am Rev Respir Dis 1989;140:368-372.
10. Logie ST, Colrain IM, Webster KE. Source dipole analysis of the early components of the RREP. Brain Topogr 1998;11:153-164.
11. Davenport PW, Colrain IM, Hill PM. Scalp topography of the short-latency components of the respiratory-related evoked potential in children. J Appl Physiol 1996;80:1785-1791.
12. Webster KE, Colrain IM. Multichannel EEG analysis of respiratory evoked-potential components during wakefulness and NREM sleep. J Appl Physiol 1998;85:1727-1735.
13. Davenport PW, Cruz M, Stecenko AA, Kifle Y. Respiratory-related evoked potentials in children with life-threatening asthma. Am J Respir Crit Care Med 2000;161:1830-1835.
14. Gora J, Trinder J, Pierce R, Colrain IM. Evidence of a sleep-specific blunted cortical response to inspiratory occlusions in mild obstructive sleep apnea syndrome. Am J Respir Crit Care Med 2002;166:1225-1234.
15. Zhao W, Martin AD, Davenport PW. Respiratory-related evoked potentials Eelicited by inspiratory occlusions in double-lung transplant recipients. J Appl Physiol 2002;93:894-902.
16. Afifi L, Guilleminault C, Colrain IM. Sleep and respiratory stimulus specific dampening of cortical responsiveness in OSAS. Respir Physiolo Neurobiol 2003;136:221-234.
17. Donzel-Raynaud C, Straus C, Bezzi M, Redolfi S, Raux M, Zelter M, Derenne JP, Similowski T. Upper airway afferents are sufficient to evoke the early components of respiratory-related cortical potentials in humans. J Appl Physiol 2004;97:1874-1879.
18. Redolfi S, Raux M, Donzel-Raynaud C, Morelot-Panzini C, Zelter M, Derenne JP, Similowski T, Straus C. Effects of upper airway anaesthesia on respiratory-related evoked potentials in humans. Eur Respir J 2005;26:1097-1103.
19. Davenport PW, Martin AD, Chou YL, Alexander-Miller S. Respiratory-related evoked potential elicited in tracheostomised lung transplant patients. Eur Respir J 2006;28:391-396.
20. Davenport PW, Chan PY, Zhang W, Chou YL. Detection threshold for inspiratory resistive loads and respiratory-related evoked potentials. J Appl Physiol 2007;102:276-285.
21. Webster KE, Colrain IM. P3-specific amplitude reductions to respiratory and auditory stimuli in subjects with asthma. Am J Respir Crit Care Med 2002;166:47-52.
22. Webster KE, Colrain IM. The relationship between respiratory-related evoked potentials and the perception of inspiratory resistive loads. Psychophysiology 2000;37:831-841.
23. Melendres M, Marcus CL, Abi-Raad R, Trescher WH, Lutz JM, Colrain IM. Respiratory-related evoked potentials during sleep in children. Sleep 2008;31:55-61.
24. Huang J, Marcus CL, Melendres MC, Karamessinis LR, Pepe ME, Samuel JM, Abi-Raad RF, Trescher WH, Colrain IM. Cortical processing of respiratory afferent stimuli during sleep in children with the obstructive sleep apnea syndrome. Sleep 2008;31:403-410.
25. Knafelc M, Davenport PW. Relationship between magnitude estimation of resistive loads, inspiratory pressures, and the RREP P(1) peak. J Appl Physiol 1999;87:516-522.
26. Webster KE, Colrain IM. The respiratory-related evoked potential: effects of attention and occlusion duration. Psychophysiology 2000;37:310-318.
27. Colrain IM, Webster KE, Hirst G. The N550 component of the evoked K-complex: a modality non-specific response? J Sleep Res 1999;8:273-280.
28. Colrain IM, Webster KE, Hirst G, Campbell KB. The roles of vertex sharp waves and K-complexes in the generation of N300 in auditory and respiratory-related evoked potentials during early stage 2 NREM sleep. Sleep 2000;23:97-106.
29. Colrain IM. The K-complex: a 7-decade history. Sleep 2005;28:255-273.
30. Huang J, Colrain IM, Bandla P. Schwartz MS, Pepe ME, Samuel JM, Panitch HB, Bradford RM, Mosse YP, Marcus CL. Afferent respiratory processing in children with the congenital central hypoventilation syndrom [abstract]. Sleep 2007;35:A84-A85.
31. Brouilette R, Hanson D, David R, Klemka L, Szatkowski A, Fernbach S, Hunt C. A diagnostic approach to suspected obstructive sleep apnea in children. J Pediatr 1984;105:10-14.
32. D'Alessandro V, Mason TBA, Pallone MN, Patano J, Marcus CL. Late-onset hypoventilation without PHOX2B mutation or hypothalamic abnormalities. J Clin Sleep Med 2005;1:169-172.
33. Eccles JC. The initiation of voluntary movements by the supplementary motor area. Arch Psychiatr Nervenkr 1982;231:423-441.
34. Brown S, Ngan E, Liotti M. A larynx area in the human motor cortex. Cereb Cortex 2008;18:837-845.
35. Linden DE. The P300: where in the brain is it produced and what does it tell us? Neuroscientist 2005;11:563-576.
36. De Gennaro L, Ferrara M, Bertini M. The spontaneous K-complex during stage 2 sleep: is it the 'forerunner' of delta waves? Neurosci Lett 2000;291:41-43.
37. Nicholas CL, Trinder J, Colrain IM. Increased production of evoked and spontaneous K-complexes following a night of fragmented sleep. Sleep 2002;25:882-887.
38. Nicholas CL, Trinder J, Crowley KE, Colrain IM. The impact of slow wave sleep proximity on evoked K-complex generation. Neurosci Lett 2006;404:127-131.
39. Cote KA, De Lugt DR, Langley SD, Campbell KB. Scalp topography of the auditory evoked K-complex in stage 2 and slow wave sleep. J Sleep Res 1999;8:263-272.
40. Orem JM, Lovering AT, Vidruk EH. Excitation of medullary respiratory neurons in REM sleep. Sleep 2005;28:801-807.
41. Fleming PJ, Cade D, Bryan MH, Bryan AC. Congenital central hypoventilation and sleep state. Pediatrics 1980;66:425-428.
42. Harper RM, Macey PM, Woo MA, Macey KE, Keens TG, Gozal D, Alger JR. Hypercapnic exposure in congenital central hypoventilation syndrome reveals CNS respiratory control mechanisms. J Neurophysiol 2005;93:1647-1658.
43. Woo MA, Macey PM, Macey KE, Keens TG, Woo MS, Harper RK, Harper RM. FMRI responses to hyperoxia in congenital central hypoventilation syndrome. Pediatr Res 2005;57:510-518.
44. Shea SA, Andres LP, Shannon DC, Guz A, Banzett RB. Respiratory sensations in subjects who lack a ventilatory response to CO2. Respir Physiol 1993;93:203-219.
45. Lavorini F, Fontana GA, Pantaleo T, Geri P, Piumelli R, Pistolesi M, Widdicombe J. Fog-induced cough with impaired respiratory sensation in congenital central hypoventilation syndrome. Am J Respir Crit Care Med 2007;176:825-832.
46. Paton JY, Swaminathan S, Sargent CW, Hawksworth A, Keens TG. Ventilatory response to exercise in children with congenital central hypoventilation syndrome. Am Rev Respir Dis 1993;147:1185-1191.
47. Gozal D, Marcus CL, Ward SL, Keens TG. Ventilatory responses to passive leg motion in children with congenital central hypoventilation syndrome. Am J Respir Crit Care Med 1996;153:761-768.
48. Marcus CL, Schwartz MS, Bandla P, Samuel JM, Pepe ME, Panitch HB, Bradford RM, Colrain IM, Mosse YP, Huang J. Spontaneous breathing in children with congenital central hypoventilation syndrome in REM vs. non-REM sleep [abstract]. Sleep 2007;30:A86-A87.
49. Weese-Mayer DE, Berry-Kravis EM, Marazita ML. In pursuit (and discovery) of a genetic basis for congenital central hHypoventilation syndrome. Respir Physiol Neurobiol 2005;149:73-82.
50. Trang H, Dehan M, Beaufils F, Zaccaria I, Amiel J, Gaultier C. The French congenital central hypoventilation syndrome registry: general data, phenotype, and genotype. Chest 2005;127:72-79.