Anti-tumor potency and toxicology of an Indian ayurvedic plant, Hygrophila spinosa

Pharmacologyonline

Volumn 2, Issue , 2008, Pages 361-371

  Pattanayak, Shakti P ^a   Sunita, P ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Acute and sub acute toxicity; Anti tumor potency; Female wistar rats; Hygrophila spinosa; Whole plant extract

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; AYURVEDIC DRUG; CARBOHYDRATE; CHOLESTEROL; ESTROGEN RECEPTOR ALPHA; FLAVONOID; HYGROPHILA SPINOSA EXTRACT; PHENOL DERIVATIVE; PHOSPHOLIPID; PHYTOSTEROL; PLANT EXTRACT; PROGESTERONE RECEPTOR; TAMOXIFEN; TANNIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ACANTHACEAE; ACUTE TOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AYURVEDA; BODY WEIGHT; BREAST ADENOCARCINOMA; CANCER CLASSIFICATION; CANCER SIZE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; EXPERIMENTAL NEOPLASM; FEMALE; HEART WEIGHT; HERBAL MEDICINE; HISTOPATHOLOGY; HYGROPHILA SPINOSA; KIDNEY MASS; LD 50; LIVER WEIGHT; LUNG WEIGHT; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PHYTOCHEMISTRY; RAT; SPLEEN WEIGHT; STATISTICAL SIGNIFICANCE; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 52649174346     PISSN: None     EISSN: 18278620     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Mehta RG. Experimental basis for the prevention of breast cancer. Eur J Cancer 2006; 36: 1275-1282.
2. Balachandran P, Govindarajan R. Cancer - an Ayurvedic perspective. Pharmacological Res 2005; 51(1): 19-30.
3. Saxena HO, Brahmam M. The flora of Orissa, Capital Business Services & Consultancy, 3rd edn., Bhubaneswar, 1995:1578-1580.
4. Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants, Council of Scientific and Industrial Research, New Delhi; 1956:29-93.
5. Anonymous. The wealth of India, A dictionary of Indian Raw Materials and Industrial Product first supplement series (Rawmaterials), 3rd vol., D-I, New Delhi; 2002.
6. Rangari V. Pharmacognosy & Phytochemistry. 1st ed. Nashik: Career Publication, 2002: 132-134.
7. Kokate CK. Practical Pharmacognosy, 3rd ed. New Delhi: Nirali Prakashan, 2003: 115-120.
8. Turner RA. Screening methods in Pharmacology, Academic press, New York, 1965:302-304.
9. King J, In: Van, D. (Ed.). Practical Clinical Enzymology, Nostrand, London, 1965: 83.
10. King J. The Phosphatases. In: Van, D., (Ed), Practical Clinical Enzymology, Nostrand, London, 1965:191-208.
11. Parekh AC, Jung DH. Cholesterol determination with ferric choloride-uranyl acetate and sulphuric acid-ferrous sulphate reagent. Analytical Chemistry 1970; 42: 1423-1427.
12. Rouser GR, Fleisher S, Yamanoro A. Two dimensional thin layer chromatographic separation of lipids and determinations of phospholipids by phosphorous analysis of spot. Lipid 1970; 5: 494-496.
13. Rice EW. Triglyceride in serum. In: Roderick, P., MacDonold, C.H. (Eds.), Standards Methods of Clinical Chemistry, 6th edition. Academic Press, New York, 1970: 215-222.
14. Henry L, Singh NP. Oral artemisinin prevents and delays the development of 7,12-dimethylbenz [a]anthracene (DMBA)-induced breast cancer in the rat. Science Direct 2006; 231:43-8.
15. Kelloff GJ, Boone CW, Steele VE, Crowell JA, Lubet R, Doody LA, Greenwald P. Development of breast cancer chemopreventive drugs. J Cell Biochem Suppl 1993; 17G: 2-13.
16. Elashry-Stowers D. Immunocytochemical localization of progesterone receptors in breast cancer with anti-human receptor monoclonal antibodies. Cancer Res 1988; 48: 6462-74.
17. Amin A, Alkaabi A, Al-Falasi S, Daoud SA. Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer, Cell Biol International 2005; 29: 687-694.
18. Sunita P, Jha S, Pattanayak SP. Health benefits of Phyto-oestrogens: a consensus review. Pharmacognosy reviews 2008; 2(3): 1-8.
19. Cassidy A, Faughnan M. Phytooestrogens through the life cycle. Procced Nutr Soc 2000; 59(2): 489-96.
20. Bingham M, Gibson G, Gottstein N, Pascual-Teresa SD, Minihane AM, Rimbach G. Gut metabolism and cardioprotective effects of dietary isoflavones. Current Topics on Nutra Res 2003; 1(1): 31-48.