Cerebellar ataxia as a possible organ-specific autoimmune disease

Movement Disorders

Volumn 23, Issue 10, 2008, Pages 1370-1377

  Hadjivassiliou, Marios ^a   Boscolo, Sabrina ^b   Tongiorgi, Enrico ^b   Grünewald, Richard A ^a   Sharrack, Basil ^a   Sanders, David S ^a   Woodroofe, Nicola ^c   Davies Jones, G Aelwyn B ^a  

^a ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF TRIESTE   (Italy)

^c SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

Author keywords

Autoimmunity; Cerebellar antibodies; HLA type; Idiopathic sporadic ataxia

Indexed keywords

AUTOANTIBODY; BRAIN ANTIBODY; CEREBELLAR ANTIBODY; HLA DQ2 ANTIGEN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CEREBELLAR ATAXIA; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENETIC ASSOCIATION; HLA TYPING; HUMAN; IDIOPATHIC DISEASE; IMMUNOPATHOLOGY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; BRAIN; CEREBELLAR ATAXIA; CEREBELLUM; DIAGNOSTIC IMAGING; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; FEMALE; HLA-DQ ANTIGENS; HUMANS; MALE; MIDDLE AGED; ORGAN SPECIFICITY; PROSPECTIVE STUDIES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 52649167340     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.22129     Document Type: Article

References (23)

1. Sutton I, Winer JB. The immunopathogenesis of paraneoplastic neurological syndromes. Clin Sci 2002;102:475-486.
2. De Silva HJ, Hoang P, Dalton H, De Silva NR, Jewell DP, Peiris JB. Immune activation during cerebellar dysfunction following Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg 1992;86:129-131.
3. Berlit P, Rakickly J. The Miller Fisher syndrome: review of the litaruture. J Clin Neuroopthalmol 1992;12:57-63.
4. Hadjivassiliou M, Boscolo S, Davies-Jones GAB, et al. The humoral response in the pathogenesis of gluten ataxia. Neurology 2002;58:1221-1226.
5. Bataller L, Graus F, Saiz A, Vilchez JJ. Clinical outcome in adult idiopathic or paraneoplastic opsoclonus-myoclonus. Brain 2001;124:437-443.
6. Meinck HM, Faber L, Morgenthaler N, et al. Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases. J Neurol Neurosurg Psychiatry 2001;71:100-103.
7. Rakocevic G, Raju R, Semino-Mora C, et al. Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies. Neurology 2006;67:1068-1070.
8. Ellis TM, Atkinson MA. The clinical significance of an autoimmune response against glutamic acid decarboxylase. Nature Med 1996;2:148-153.
9. Barova H, Perusicova J, Hill M, et al. Anti-GAD positive patients with Type 1 diabetes mellitus have higher prevalence of autoimmune thyroiditis than anti GAD negative patients with Type 1 and Type 2 diabetes Mellitus. Physiol Res 2004;53:279-286.
10. Hadjivassiliou M, Grünewald RA, Sharrack B, et al. Gluten ataxia in perspective: epidemiology, genetic susceptibility and clinical characteristics. Brain 2003;126:685-691.
11. Serjeantson SW, Court J, Mackay IR, et al. HLA-DQ genotypes are associated with autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes mellitus patients. Human Immunol 1993;38:97-104.
12. Pugliese A, Solimena M, Awdeh ZL, et al. Association of HLA-DQB1 0201 with stiff-man syndrome. J Clin Endocrinol Metab 1993;77:1550-1553.
13. Segni M, Pani MA, Pasquino AM, et al. Familial clustering of juvenile thyroid autoimmunity: higher risk is conferred by human leukocyte antigen DR3-DQ2 and thuroid peroxidase antibody status in fathers. J Clin Endocrinol Metab 2002;87:3779-3782.
14. Eisenbarth GS, Gottlieb PA. Autoimmune polyendocrine syndromes. N Engl J Med 2004;350:2068-2079.
15. Boscolo S, Passoni M, Baldas V, et al. Detection of antibrain serum antibodies using a semi-quantitative immunohistological method. Journal of immunological methods 2005;309: 139-149.
16. Douglass C, Survana K, Reilly MM, et al. A novel amyloidogenic transthyretin variant Gly53Ala associated with intermittent headaches and ataxia. J Neurol Neurosurg Psychiatry 2007;78: 193-195.
17. Rose NR, Mackay IR. The autoimmune diseases, 3rd ed. New York: Academic Press, 1998.
18. Hadjivassiliou M, Sanders DS, Woodroofe N, Williamson CA, Grunewald RA. Gluten ataxia. The Cerebellum (in press).
19. Boscolo S, Sarich A, Lorenzon A, et al. Gluten ataxia: passive transfer in a mouse model. NY Acad Sci 2007;1107:319-328.
20. Zuliani L, Sabater L, Saiz A, Baiges JJ, Giometto B, Graus F. Homer 3 autoimmunity in subacute idiopathic cerebellar ataxia. Neurology 2007;68:239-240.
21. Manto M, Laure M, Aguera M, Rogemond V, Pandolfo M, Honnorat J. Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases. Ann Neurol 2007;61:544-551.
22. Wong S, Pollock AN, Burnham JM, et al. Acute cerebellar ataxia due to Sjogren syndrome. Neurology 2004;62:2332-2333.
23. Bürk K, Melms A, Schulz JB, Dichgans J. Effectiveness of intravenous immunoglobin therapy in cerebellar ataxia associated with gluten sensitivity. Ann Neurol 2001b;50:827-828.