Genetic and environmental findings in early-onset Parkinson's disease Brazilian patients

Movement Disorders

Volumn 23, Issue 9, 2008, Pages 1228-1233

  Aguiar, Patricia de Carvalho ^a,b,d   Lessa, Patricia Silva ^a,c   Godeiro Jr , Clecio ^a,b   Barsottini, Orlando ^a,b   Felício, Andre Carvalho ^a,b   Borges, Vanderci ^b   Silva, Sonia Maria de Azevedo ^b   Saba, Roberta Arb ^b   Ferraz, Henrique Ballalai ^b   Moreira Filho, Carlos A ^a,c   Andrade, Luiz Augusto F ^a  

^a HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d NONE   (Brazil)

Author keywords

Environment; Genetics; PARK2; PARK8; Parkinson's disease; Polymorphism

Indexed keywords

ASPARAGINE; DRINKING WATER; LEUCINE; PARKIN; PARKIN 2; PARKIN 8; SERINE; UNCLASSIFIED DRUG; VALINE; WELL WATER;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BRAZIL; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FEMALE; GENE INTERACTION; GENE MUTATION; GENETIC CORRELATION; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARKINSON DISEASE; PRIORITY JOURNAL; RISK FACTOR; RURAL AREA; SMOKING; WATER SUPPLY;

EID: 52649164698     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.22032     Document Type: Article

References (15)

1. Warner TT, Schapira AH. Genetic and environmental factors in the cause of Parkinson's disease. Ann Neurol 2003;53 (Suppl 3): S16-S23.
2. Klein C, Schlossmacher MG. Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder. Neurology 2007;69:2093-2104.
3. Kitada T, Asakawa S, Hattori N, et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998;392:605-608.
4. Klein C, Lohmann-Hedrich K, Rogaeva E, Schlossmacher MG, Lang AE. Deciphering the role of heterozygous mutations in genes associated with parkinsonism. Lancet Neurol 2007;6:652-662.
5. Paisan-Ruiz C, Jain S, Evans EW, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004;44:595-600.
6. Zimprich A, Biskup S, Leitner P, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 2004;44:601-607.
7. Goldwurm S, Di Fonzo A, Simons EJ, et al. The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor. J Med Genet 2005;42:e65.
8. Priyadarshi A, Khuder SA, Schaub EA, Priyadarshi SS. Environmental risk factors and Parkinson's disease: a metaanalysis. Environ Res 2001;86:122-127.
9. Chade AR, Kasten M, Tanner CM. Nongenetic causes of Parkinson's disease. J Neural Transm Suppl 2006;70:147-151.
10. Hedrich K, Eskelson C, Wilmot B, et al. Distribution, type, and origin of Parkin mutations: review and case studies. Mov Disord 2004;19:1146-1157.
11. Rankin CA, Joazeiro CA, Floor E, Hunter T. E3 ubiquitin-protein ligase activity of Parkin is dependent on cooperative interaction of RING finger (TRIAD) elements. J Biomed Sci 2001;8: 421-429.
12. Elbaz A, Levecque C, Clavel J, et al. CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. Ann Neurol 2004;55: 430-434.
13. Ghione I, Di Fonzo A, Saladino F, et al. Parkin polymorphisms and environmental exposure: decrease in age at onset of Parkinson's disease. Neurotoxicology 2007;28:698-701.
14. Klein C, Schumacher K, Jacobs H, et al. Association studies of Parkinson's disease and parkin polymorphisms. Ann Neurol 2000; 48:126-127.
15. Lucking CB, Chesneau V, Lohmann E, et al. Coding polymorphisms in the parkin gene and susceptibility to Parkinson disease. Arch Neurol 2003;60:1253-1256.