Selected physical and chemical properties of commercial hypericum perforatum extracts relevant for formulated product quality and performance

AAPS Journal

Volumn 3, Issue 4, 2001, Pages

  Kopleman, Susan H ^a   Augsburger, Larry L ^a   NguyenPho, Agnes ^b   Zito, William S ^c   Muller, Fran X ^d  

^a UNIVERSITY OF MARYLAND   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c ST JOHN'S UNIVERSITY   (United States)

^d GLAXOSMITHKLINE   (United States)

Author keywords

Hypericum perforatum; Nutraceuticals; St John's Wort

Indexed keywords

EID: 52549120774     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Barnes J, Anderson LA, Phillipson D. St. John's Wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2001; 53(5):583-600.
2. Consumer safety symposium on dietary supplements and herbs [press release]. New York: Good Housekeeping Institute; March 3, 1998.
3. Gurley BJ, Gardner SF, Hubbard MA. Content versus label claims in ephedra-containing dietary supplements. Am J Health Sys Pharm. 2000; 57:963-969.
4. Cui J, Garle M, Eneroth P, Bjorkhem I. What do commercial ginseng preparations contain? Lancet. 1994;344(8915):134.
5. Herbal Rx-the promises and the pitfalls. Cons Rep. 1999;May:44-48.
6. Kopelman SH, Augsburger LL. Some Physical Properties of Ginkgo biloba Extracts Important for Tableting and Encapsulation. JANA 2000;3(2):32-37.
7. Butterweck V, Jurgenliemk G, Nahrstedt A, Winterhoff H. Flavonoids from Hypericum peforatum show antidepressant activity in the forced swimming test. Planta Med. 2000;66(l):3-6.
8. Sparenberg B, Demisch E, Holzl J. Investigations of the antidepressive effects of St. John's wort. Pz Wissenschaft. 1993;138(2):50-54.
9. Calapai G, Crupi A, Firenzuoli F, et al. Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat. J Pharm Pharmacol. 1999;51(6):723-728.
10. Calapai G, Crupi A, Firenzuoli F, et al. Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatum. Pharmacopsychiatry. 2001;34(2):45-49.
11. Sloley BD, Urichuk EJ, Eing E, et al. Chemical and pharmacological evaluation of Hypericum perforatum extracts. Acta Pharmacol. Sin. 2000;21(12): 1145-1152.
12. Chatterjee SS, Noldner M, Koch M, Erdelmeier C. Antidepressant activity of Hypericum perforatum E. and hyperforin, the neglected possibility. Pharmacopsychiatry. 1998;31(1):7-15.
13. Eavie G, Mazur Y, Eavie D, et al. Hypericin as an inactivator of infectious viruses in blood components. Transfusion. 1995;35(5):392-400.
14. Chatterjee SS, Bhattacharya SK, Wonnemann M, et al. Hyperforin as a possible antidepressant component of hypericum extracts. Eife Sci. 1998;63(6):499-510.
15. Eaakmann G, Schule C, Baghai T, Kieser M. St. John's Wort in mild to moderate depression: The relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry. 1998;31:54-59.
16. MelzerM, Fuhrken D, Kolkmann R. Hyperforin in St. John's Wort: main active principle or only a key substance? Deut Apoth Zeitung. 1998;138(December):56-62.
17. INA Methods Validation Program. Hypericum perforatum constituent identification by HPEC. 104.000. Institute for Nutraceutical Advancement. Denver, CO; 2000.
18. Brolis M, Gabetta B, Fuzzati N, et al. Identification of highperformance liquid chromatography-diode array detection-mass spectrometry and quantificaiton by high performance liquid chromatography-UV absorbance detection of active constituents of Hypericum perforatum. J Chromatogr A. 1998;825:9-16.
19. Bilia AR, Bergonzi MC, Morgenni F, et al. Evaluation of chemical stability of St. John's wort commercial extract and some preparations. Int J Pharm. 2001;213:199-208.
20. INA Methods Validation Program. Determination of hypericin and pseudohypericin in St. John's Wort by high-performance liquid chromatography. 107.000. Institute for Nutraceutical Advancement. Denver, CO;2000:1-4.
21. INA Methods Validation Program. Determination of hyperforin in St. John's Wort extract and plant material by high-performance liquid chromatography. 112.000. Institute for Nutraceutical Advancement. Denver, CO;2000:1-4.
22. Maisenbacher P, Kovar KA. Analysis and stability of hyperici oleum. Planta Med. 1992;58(4):351-354.
23. Orth HCJ, Schmidt PC. Stability and stabilization of hyperforin. Pharm. Ind. 2000;62(l):60-63.
24. Fourneron J, Herbette G, Caloprisco E. Pseudohypericin and hypericin in St. John's Wort extracts. Breakdown of pseudohypericin. Comptes Rendes de L'Academie des Sciences Série II Fascicule C-Chimie. 1999;2(3): 127-131.
25. Carr RL. Particle behavior, storage, and flow. Brit Chem Eng 1970; 15:1541-1549.
26. U.S. Pharmacopeial Convention, Inc. Physical tests and determinations -bulk density and tapped density. The United States Pharmacopeia-Pharmacopeial Forum. 24th ed. Rockville, MD: U S Pharmacopeial Convention, Inc.; 1998:6569-6570.
27. Gioia A. Intrinsic flowability: a new technology for powder flowability classification. Pharm Technol. 1980;February:65-68.
28. Callahan JC, Cleary GW, Elefant M, et al. Equilibrium moisture content of pharmaceutical excipients. Drug Dev Ind Pharm. 1982;8(3):355-369.
29. Heda PK, Muller FX, Augsburger EE. Capsule filling machine simulation. Part 1. Eow-force powder compression physics relevant to plug formation. Pharm Dev Tech. 1999;4(2):209-219.
30. Shah K. The influence of important machine operating variables on slug formation, fill weight, and drug release from a dosing disc type automatic capsule filling machine. Ph.D. Dissertation. University of Maryland. Baltimore, MD; 1986.
31. Nelson E, Naqvi SM, Busse EW, Higuchi T. Physics of tablet compression IV. Relationship of ejection and upper and lower punch forces during the compressional process: application of measurements to comparison of ablet lubricants. J Am Pharm Assoc Sei Ed. 1954;43:596-602.
32. Shaxby JH, Evans JC. The variation of présure with depth in columns of powders. Trans Faraday Soc. 1923; 19:60-72.
33. Heckel RW. Density-pressure relationships in powder compression. TransMetall Soc A IM E 1961;221:671-675.
34. Kawakita K, Eudde K.H. Some considerations on powder compression equations. Powder Technol. 1970;4:61-68.
35. Augsburger EE. Hard and soft shell capsules. In: Banker G, Rhodes CT, eds. Modern Pharmaceutics. New York: M arcel Dekker, Inc;1995: 441-490.
36. Kontny MJ, Mulski CA. Gelatin capsule brittleness as a function of relative humidity at room temperature. Int J Pharm. 1989;54:79-85.
37. Bell JH, Stevenson NA, Taylor JE. A moisture transfer effect in hard gelatin capsules of sodium cromoglycate. J Pharm Pharmacol. 1973;25(suppl):96P-103P.