메뉴 건너뛰기




Volumn 27, Issue 4, 2008, Pages 575-587

The role of DNA synthesis imaging in cancer in the era of targeted therapeutics

Author keywords

DNA synthesis; FAU; FBAU; FMAU; Proliferation; Thymidine; Thymidine kinase; Thymidine phosphorylase; Thymidylate synthase

Indexed keywords

1 (2' DEOXY 2' FLUORO 1 BETA DARABINOFURANOSYL) 5 BROMOURACIL BR 76; 1 (2' DEOXY 2' FLUORO 1 BETA DARABINOFURANOSYL) 5 BROMOURACIL F 18; 1 (2' DEOXY 2' FLUORO 1 BETA DEXTRO ARABINOFURANOSYL) METHYLURACIL C 11; 1 (2' DEOXY 2' FLUORO 1 BETA DEXTRO ARABINOFURANOSYL) METHYLURACIL F 18; 1 (2' DEOXY 2' FLUORO BETA DEXTRO ARABINOFURANOSYL) URACIL C 14; 1 (2' DEOXY 2' FLUORO BETA DEXTRO ARABINOFURANOSYL) URACIL F 18; 3' DEOXY 3' FLUORODEOXYTHYMIDINE F 18; 4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; 5' DEOXY 5' FLUOROTHYMIDINE F 18; AURORA KINASE INHIBITOR; BROMINE 76; BROXURIDINE; CANERTINIB; CAPECITABINE F 18; CARBON 11; CCT 129202; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUORODEOXYGLUCOSE; FLUORODEOXYGLUCOSE F 18; FLUOROURACIL; GEMCITABINE; IDOXURIDINE; METHOTREXATE; PREDNISONE; RADIOPHARMACEUTICAL AGENT; RITUXIMAB; THYMIDINE C 11; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

EID: 52549092163     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-008-9148-5     Document Type: Review
Times cited : (15)

References (125)
  • 7
    • 0024151061 scopus 로고
    • Local Re-utilization of thymidine in normal mouse tissues as measured with iododeoxyuridine
    • R. C. Quackenbush A. F. Shields 1988 Local Re-utilization of thymidine in normal mouse tissues as measured with iododeoxyuridine Cell and Tissue Kinetics 21 381 387
    • (1988) Cell and Tissue Kinetics , vol.21 , pp. 381-387
    • Quackenbush, R.C.1    Shields, A.F.2
  • 9
    • 0016253656 scopus 로고
    • Expression of thymidine kinase variants is a function of the replicative state of cells
    • R. Adler B. R. McAuslan 1974 Expression of thymidine kinase variants is a function of the replicative state of cells Cell 2 113 117
    • (1974) Cell , vol.2 , pp. 113-117
    • Adler, R.1    McAuslan, B.R.2
  • 10
    • 0016147460 scopus 로고
    • Regulation of thymidine kinase synthesis in human cells
    • L. J. Bello 1974 Regulation of thymidine kinase synthesis in human cells Experimental Cell Research 89 263 274
    • (1974) Experimental Cell Research , vol.89 , pp. 263-274
    • Bello, L.J.1
  • 11
    • 0019988178 scopus 로고
    • Regulation of thymidine kinase enzyme level in serum-stimulated mouse 3T6 fibroblasts
    • L. F. Johnson L. G. Rao A. J. Muench 1982 Regulation of thymidine kinase enzyme level in serum-stimulated mouse 3T6 fibroblasts Experimental Cell Research 138 79 85
    • (1982) Experimental Cell Research , vol.138 , pp. 79-85
    • Johnson, L.F.1    Rao, L.G.2    Muench, A.J.3
  • 12
    • 0023879292 scopus 로고
    • Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells
    • J. L. Sherley T. J. Kelly 1988 Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells Journal of Biological Chemistry 263 375 382
    • (1988) Journal of Biological Chemistry , vol.263 , pp. 375-382
    • Sherley, J.L.1    Kelly, T.J.2
  • 13
    • 0035367928 scopus 로고    scopus 로고
    • Thymidine kinase as a proliferative marker: Clinical relevance in 1,692 primary breast cancer patients
    • P. Broet S. Romain A. Daver G. Ricolleau V. Quillien A. Rallet 2001 Thymidine kinase as a proliferative marker: Clinical relevance in 1,692 primary breast cancer patients Journal of Clinical Oncology 19 2778 2787
    • (2001) Journal of Clinical Oncology , vol.19 , pp. 2778-2787
    • Broet, P.1    Romain, S.2    Daver, A.3    Ricolleau, G.4    Quillien, V.5    Rallet, A.6
  • 14
    • 0026668209 scopus 로고
    • Thymidine kinase: A tumor marker with prognostic value for non-Hodgkin's lymphoma and a broad range of potential clinical applications
    • M. Hallek L. Wanders S. Strohmeyer B. Emmerich 1992 Thymidine kinase: A tumor marker with prognostic value for non-Hodgkin's lymphoma and a broad range of potential clinical applications Annals of Hematology 65 1 5
    • (1992) Annals of Hematology , vol.65 , pp. 1-5
    • Hallek, M.1    Wanders, L.2    Strohmeyer, S.3    Emmerich, B.4
  • 17
    • 0028054863 scopus 로고
    • G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter
    • Q. P. Dou S. Zhao A. H. Levin J. Wang K. Helin A. B. Pardee 1994 G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter Journal of Biological Chemistry 269 1306 1313
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 1306-1313
    • Dou, Q.P.1    Zhao, S.2    Levin, A.H.3    Wang, J.4    Helin, K.5    Pardee, A.B.6
  • 19
    • 0029036377 scopus 로고
    • The catalytic mechanism and structure of thymidylate synthase
    • C. W. Carreras D. V. Santi 1995 The catalytic mechanism and structure of thymidylate synthase Annual Reviews of Biochemical 64 721 762
    • (1995) Annual Reviews of Biochemical , vol.64 , pp. 721-762
    • Carreras, C.W.1    Santi, D.V.2
  • 21
    • 0032994840 scopus 로고    scopus 로고
    • Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines
    • B. van Triest H. M. Pinedo Y. van Hensbergen K. Smid F. Telleman P. S. Schoenmakers 1999 Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines Clinical Cancer Research 5 643 654
    • (1999) Clinical Cancer Research , vol.5 , pp. 643-654
    • Van Triest, B.1    Pinedo, H.M.2    Van Hensbergen, Y.3    Smid, K.4    Telleman, F.5    Schoenmakers, P.S.6
  • 23
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • P. G. Johnston H. J. Lenz C. G. Leichman K. D. Danenberg C. J. Allegra P. V. Danenberg 1995 Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors Cancer Research 55 1407 1412
    • (1995) Cancer Research , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3    Danenberg, K.D.4    Allegra, C.J.5    Danenberg, P.V.6
  • 24
    • 77049163441 scopus 로고
    • The enzymatic synthesis of nucleosides. II. Thymidine and related pyrimidine nucleosides
    • M. Friedkin D. Roberts 1954 The enzymatic synthesis of nucleosides. II. Thymidine and related pyrimidine nucleosides Journal of Biological Chemistry 207 257 266
    • (1954) Journal of Biological Chemistry , vol.207 , pp. 257-266
    • Friedkin, M.1    Roberts, D.2
  • 25
    • 77049164570 scopus 로고
    • The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue
    • M. Friedkin D. Roberts 1954 The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue Journal of Biological Chemistry 207 245 256
    • (1954) Journal of Biological Chemistry , vol.207 , pp. 245-256
    • Friedkin, M.1    Roberts, D.2
  • 26
    • 0022345955 scopus 로고
    • Kinetic studies of thymidine phosphorylase from mouse liver
    • M. H. Iltzsch M. H. el Kouni S. Cha 1985 Kinetic studies of thymidine phosphorylase from mouse liver Biochemistry 24 6799 6807
    • (1985) Biochemistry , vol.24 , pp. 6799-6807
    • Iltzsch, M.H.1    El Kouni, M.H.2    Cha, S.3
  • 29
    • 14644393663 scopus 로고    scopus 로고
    • Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment
    • M. Toi M. A. Rahman H. Bando L. W. C. Chow 2005 Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment The Lancet Oncology 6 158 166
    • (2005) The Lancet Oncology , vol.6 , pp. 158-166
    • Toi, M.1    Rahman, M.A.2    Bando, H.3    Chow, L.W.C.4
  • 30
    • 0034754268 scopus 로고    scopus 로고
    • Thymidine phosphorylase as a target for imaging and therapy with thymine analogs
    • R. W. Klecker Jr. J. M. Collins 2001 Thymidine phosphorylase as a target for imaging and therapy with thymine analogs Cancer Chemotherapy and Pharmacology 48 407 412
    • (2001) Cancer Chemotherapy and Pharmacology , vol.48 , pp. 407-412
    • Klecker Jr., R.W.1    Collins, J.M.2
  • 31
    • 0027253923 scopus 로고
    • Studies with positron emission tomography after systemic administration of fluorine-18-uracil in patients with liver metastases from colorectal carcinoma
    • A. Dimitrakopoulou L. G. Strauss J. H. Clorius H. Ostertag P. Schlag M. Heim 1993 Studies with positron emission tomography after systemic administration of fluorine-18-uracil in patients with liver metastases from colorectal carcinoma Journal of Nuclear Medicine 34 1075 1081
    • (1993) Journal of Nuclear Medicine , vol.34 , pp. 1075-1081
    • Dimitrakopoulou, A.1    Strauss, L.G.2    Clorius, J.H.3    Ostertag, H.4    Schlag, P.5    Heim, M.6
  • 34
    • 0030482685 scopus 로고    scopus 로고
    • A graphical analysis method for estimating blood-to-tissue transfer constants for tracers with labeled metabolites
    • D. A. Mankoff A. F. Shields M. M. Graham J. M. Link K. A. Krohn 1996 A graphical analysis method for estimating blood-to-tissue transfer constants for tracers with labeled metabolites Journal of Nuclear Medicine 37 2049 2057
    • (1996) Journal of Nuclear Medicine , vol.37 , pp. 2049-2057
    • Mankoff, D.A.1    Shields, A.F.2    Graham, M.M.3    Link, J.M.4    Krohn, K.A.5
  • 36
    • 0031864751 scopus 로고    scopus 로고
    • Kinetic analysis of 2-[carbon-11]thymidine PET imaging studies: Compartmental model and mathematical analysis
    • D. A. Mankoff A. F. Shields M. M. Graham J. M. Link J. F. Eary K. A. Krohn 1998 Kinetic analysis of 2-[carbon-11]thymidine PET imaging studies: Compartmental model and mathematical analysis Journal of Nuclear Medicine 39 1043 1055
    • (1998) Journal of Nuclear Medicine , vol.39 , pp. 1043-1055
    • Mankoff, D.A.1    Shields, A.F.2    Graham, M.M.3    Link, J.M.4    Eary, J.F.5    Krohn, K.A.6
  • 37
    • 0021274838 scopus 로고
    • Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors
    • A. Russo L. Gianni T. J. Kinsella R. W. Klecker Jr. J. Jenkins J. Rowland 1984 Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors Cancer Research 44 1702 1705
    • (1984) Cancer Research , vol.44 , pp. 1702-1705
    • Russo, A.1    Gianni, L.2    Kinsella, T.J.3    Klecker Jr., R.W.4    Jenkins, J.5    Rowland, J.6
  • 44
    • 0036205096 scopus 로고    scopus 로고
    • Basis of FLT as a cell proliferation marker: Comparative uptake studies with [3H]thymidine and [3H]arabinothymidine, and cell-analysis in 22 asynchronously growing tumor cell lines
    • J. Toyohara A. Waki S. Takamatsu Y. Yonekura Y. Magata Y. Fujibayashi 2002 Basis of FLT as a cell proliferation marker: Comparative uptake studies with [3H]thymidine and [3H]arabinothymidine, and cell-analysis in 22 asynchronously growing tumor cell lines Nuclear Medicine and Biology 29 281 287
    • (2002) Nuclear Medicine and Biology , vol.29 , pp. 281-287
    • Toyohara, J.1    Waki, A.2    Takamatsu, S.3    Yonekura, Y.4    Magata, Y.5    Fujibayashi, Y.6
  • 45
    • 1842850610 scopus 로고    scopus 로고
    • Effect of p53 activation on cell growth, thymidine kinase-1 activity, and 3′-deoxy-3′fluorothymidine uptake
    • J. L. Schwartz Y. Tamura R. Jordan J. R. Grierson K. A. Krohn 2004 Effect of p53 activation on cell growth, thymidine kinase-1 activity, and 3′-deoxy-3′fluorothymidine uptake Nuclear Medicine and Biology 31 419 423
    • (2004) Nuclear Medicine and Biology , vol.31 , pp. 419-423
    • Schwartz, J.L.1    Tamura, Y.2    Jordan, R.3    Grierson, J.R.4    Krohn, K.A.5
  • 47
    • 2342617500 scopus 로고    scopus 로고
    • Monitoring of therapy in androgen-dependent prostate tumor model by measuring tumor proliferation
    • N. Oyama D. E. Ponde C. Dence J. Kim Y. C. Tai M. J. Welch 2004 Monitoring of therapy in androgen-dependent prostate tumor model by measuring tumor proliferation Journal of Nuclear Medicine 45 519 525
    • (2004) Journal of Nuclear Medicine , vol.45 , pp. 519-525
    • Oyama, N.1    Ponde, D.E.2    Dence, C.3    Kim, J.4    Tai, Y.C.5    Welch, M.J.6
  • 48
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • C. J. Sherr J. M. Roberts 1995 Inhibitors of mammalian G1 cyclin-dependent kinases Genes & Development 9 1149 1163
    • (1995) Genes & Development , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 49
    • 0033550316 scopus 로고    scopus 로고
    • Transcription factors of the Sp1 family: Interaction with E2F and regulation of the murine thymidine kinase promoter
    • H. Rotheneder S. Geymayer E. Haidweger 1999 Transcription factors of the Sp1 family: Interaction with E2F and regulation of the murine thymidine kinase promoter Journal of Molecular Biology 293 1005 1015
    • (1999) Journal of Molecular Biology , vol.293 , pp. 1005-1015
    • Rotheneder, H.1    Geymayer, S.2    Haidweger, E.3
  • 54
    • 0141593496 scopus 로고    scopus 로고
    • NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
    • L. Catley E. Weisberg Y. T. Tai P. Atadja S. Remiszewski T. Hideshima 2003 NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma Blood 102 2615 2622
    • (2003) Blood , vol.102 , pp. 2615-2622
    • Catley, L.1    Weisberg, E.2    Tai, Y.T.3    Atadja, P.4    Remiszewski, S.5    Hideshima, T.6
  • 56
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: Receptor heterodimerization in development and cancer
    • M. A. Olayioye R. M. Neve H. A. Lane N. E. Hynes 2000 The ErbB signaling network: receptor heterodimerization in development and cancer EMBO Journal 19 3159 3167
    • (2000) EMBO Journal , vol.19 , pp. 3159-3167
    • Olayioye, M.A.1    Neve, R.M.2    Lane, H.A.3    Hynes, N.E.4
  • 57
    • 34548535031 scopus 로고    scopus 로고
    • Multicenter, randomized, phase II trial of CI-1033, an irreversible pan-ERBB inhibitor, for previously treated advanced non small-cell lung cancer
    • P. A. Janne J. von Pawel R. B. Cohen L. Crino C. A. Butts S. S. Olson 2007 Multicenter, randomized, phase II trial of CI-1033, an irreversible pan-ERBB inhibitor, for previously treated advanced non small-cell lung cancer Journal of Clinical Oncology 25 3936 3944
    • (2007) Journal of Clinical Oncology , vol.25 , pp. 3936-3944
    • Janne, P.A.1    Von Pawel, J.2    Cohen, R.B.3    Crino, L.4    Butts, C.A.5    Olson, S.S.6
  • 61
    • 37549027270 scopus 로고    scopus 로고
    • Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity
    • F. Chan C. Sun M. Perumal Q. D. Nguyen V. Bavetsias E. McDonald 2007 Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity Molecular Cancer Therapeutics 6 3147 3157
    • (2007) Molecular Cancer Therapeutics , vol.6 , pp. 3147-3157
    • Chan, F.1    Sun, C.2    Perumal, M.3    Nguyen, Q.D.4    Bavetsias, V.5    McDonald, E.6
  • 62
    • 0037742189 scopus 로고    scopus 로고
    • 18F-]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography
    • 18F-]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography Cancer Research 63 3791 3798
    • (2003) Cancer Research , vol.63 , pp. 3791-3798
    • Barthel, H.1    Cleij, M.C.2    Collingridge, D.R.3    Hutchinson, O.C.4    Osman, S.5    He, Q.6
  • 66
    • 0025916482 scopus 로고
    • Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides
    • B. Munch-Petersen L. Cloos G. Tyrsted S. Eriksson 1991 Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides Journal of Biological Chemistry 266 9032 9038
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 9032-9038
    • Munch-Petersen, B.1    Cloos, L.2    Tyrsted, G.3    Eriksson, S.4
  • 73
    • 52549120831 scopus 로고    scopus 로고
    • Monitoring of radiation effects with FLT-PET imaging
    • Society of Molecular Imaging and Academy of Molecular Imaging: Providence, RI.
    • Jeraj, R., McCall, K., Simoncic, U., & Nickles, J. (2007). Monitoring of radiation effects with FLT-PET imaging. In Joint Molecular Imaging Conference, Society of Molecular Imaging and Academy of Molecular Imaging: Providence, RI.
    • (2007) Joint Molecular Imaging Conference
    • Jeraj, R.1    McCall, K.2    Simoncic, U.3    Nickles, J.4
  • 74
    • 52549084650 scopus 로고    scopus 로고
    • Positron-emission tomography reveals early flare in uptake of FLT in tumors following chemotherapy with gemcitabine
    • [abstract] Society of Molecular Imaging and Academy of Molecular Imaging: Providence, RI.
    • McArthur, G., Hicks, R., Binns, D., Shalinsky, D., McCarthy, T., Anderes, K., et al. (2007). Positron-emission tomography reveals early flare in uptake of FLT in tumors following chemotherapy with gemcitabine. [abstract]. In Joint Molecular Imaging Conference, Society of Molecular Imaging and Academy of Molecular Imaging: Providence, RI.
    • (2007) Joint Molecular Imaging Conference
    • McArthur, G.1    Hicks, R.2    Binns, D.3    Shalinsky, D.4    McCarthy, T.5    Anderes, K.6
  • 81
    • 0038179858 scopus 로고    scopus 로고
    • 18F-]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-cell lymphoma model and in the human disease
    • 18F-]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-cell lymphoma model and in the human disease Cancer Research 63 2681 2687
    • (2003) Cancer Research , vol.63 , pp. 2681-2687
    • Wagner, M.1    Seitz, U.2    Buck, A.3    Neumaier, B.4    Schultheiss, S.5    Bangerter, M.6
  • 83
    • 34247189630 scopus 로고    scopus 로고
    • Functional diagnosis of residual lymphomas after radiochemotherapy with positron emission tomography comparing FDG-and FLT-PET
    • B. Kasper G. Egerer M. Gronkowski S. Haufe T. Lehnert M. Eisenhut 2007 Functional diagnosis of residual lymphomas after radiochemotherapy with positron emission tomography comparing FDG-and FLT-PET Leukemia & Lymphoma 48 746 753
    • (2007) Leukemia & Lymphoma , vol.48 , pp. 746-753
    • Kasper, B.1    Egerer, G.2    Gronkowski, M.3    Haufe, S.4    Lehnert, T.5    Eisenhut, M.6
  • 89
  • 91
    • 1842850609 scopus 로고    scopus 로고
    • Pharmacokinetics of the thymidine analog 2′-fluoro-5-methyl-1-beta- d-arabinofuranosyluracil (FMAU) in tumor-bearing rats
    • J. R. Bading A. H. Shahinian A. Vail P. Bathija G. W. Koszalka R. T. Koda 2004 Pharmacokinetics of the thymidine analog 2′-fluoro-5-methyl-1-beta- d-arabinofuranosyluracil (FMAU) in tumor-bearing rats Nuclear Medicine and Biology 31 407 418
    • (2004) Nuclear Medicine and Biology , vol.31 , pp. 407-418
    • Bading, J.R.1    Shahinian, A.H.2    Vail, A.3    Bathija, P.4    Koszalka, G.W.5    Koda, R.T.6
  • 92
    • 0029088368 scopus 로고
    • Clinicopathological stages and pyrimidine nucleotide synthesis in human mammary carcinomas
    • M. Ebuchi S. Sakamoto H. Kudo J. Nagase M. Endo 1995 Clinicopathological stages and pyrimidine nucleotide synthesis in human mammary carcinomas Anticancer Research 15 1481 1484
    • (1995) Anticancer Research , vol.15 , pp. 1481-1484
    • Ebuchi, M.1    Sakamoto, S.2    Kudo, H.3    Nagase, J.4    Endo, M.5
  • 95
    • 0032771837 scopus 로고    scopus 로고
    • Suicide prodrugs activated by thymidylate synthase: Rationale for treatment and noninvasive imaging of tumors with deoxyuridine analogues
    • J. M. Collins R. W. Klecker A. G. Katki 1999 Suicide prodrugs activated by thymidylate synthase: Rationale for treatment and noninvasive imaging of tumors with deoxyuridine analogues Clinical Cancer Research 5 1976 1981
    • (1999) Clinical Cancer Research , vol.5 , pp. 1976-1981
    • Collins, J.M.1    Klecker, R.W.2    Katki, A.G.3
  • 97
    • 0033623354 scopus 로고    scopus 로고
    • Synthesis of [76Br]bromofluorodeoxyuridine and its validation with regard to uptake, DNA incorporation, and excretion modulation in rats
    • L. Lu M. Bergstrom K. J. Fasth B. Langstrom 2000 Synthesis of [76Br]bromofluorodeoxyuridine and its validation with regard to uptake, DNA incorporation, and excretion modulation in rats Journal of Nuclear Medicine 41 1746 1752
    • (2000) Journal of Nuclear Medicine , vol.41 , pp. 1746-1752
    • Lu, L.1    Bergstrom, M.2    Fasth, K.J.3    Langstrom, B.4
  • 103
    • 0021222361 scopus 로고
    • Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717
    • A. L. Jackman G. A. Taylor A. H. Calvert K. R. Harrap 1984 Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717 Biochemical Pharmacology 33 3269 3275
    • (1984) Biochemical Pharmacology , vol.33 , pp. 3269-3275
    • Jackman, A.L.1    Taylor, G.A.2    Calvert, A.H.3    Harrap, K.R.4
  • 104
    • 0025997350 scopus 로고
    • ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study
    • A. L. Jackman G. A. Taylor W. Gibson R. Kimbell M. Brown A. H. Calvert 1991 ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study Cancer Research 51 5579 5586
    • (1991) Cancer Research , vol.51 , pp. 5579-5586
    • Jackman, A.L.1    Taylor, G.A.2    Gibson, W.3    Kimbell, R.4    Brown, M.5    Calvert, A.H.6
  • 105
    • 0021294664 scopus 로고
    • Plasma nucleoside and base levels following treatment with the new thymidylate synthetase inhibitor CB 3717
    • G. A. Taylor A. L. Jackman A. H. Calvert K. R. Harrap 1984 Plasma nucleoside and base levels following treatment with the new thymidylate synthetase inhibitor CB 3717 Advances in Experimental Medicine and Biology 165 Pt B 379 382
    • (1984) Advances in Experimental Medicine and Biology , vol.165 , pp. 379-382
    • Taylor, G.A.1    Jackman, A.L.2    Calvert, A.H.3    Harrap, K.R.4
  • 106
    • 33748992895 scopus 로고    scopus 로고
    • Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography
    • M. Perumal R. G. Pillai H. Barthel J. Leyton J. R. Latigo M. Forster 2006 Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography Cancer Research 66 8558 8564
    • (2006) Cancer Research , vol.66 , pp. 8558-8564
    • Perumal, M.1    Pillai, R.G.2    Barthel, H.3    Leyton, J.4    Latigo, J.R.5    Forster, M.6
  • 107
    • 0141678071 scopus 로고    scopus 로고
    • Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer
    • Y. C. Hu R. A. Komorowski S. Graewin G. Hostetter O. P. Kallioniemi H. A. Pitt 2003 Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer Clinical Cancer Research 9 4165 4171
    • (2003) Clinical Cancer Research , vol.9 , pp. 4165-4171
    • Hu, Y.C.1    Komorowski, R.A.2    Graewin, S.3    Hostetter, G.4    Kallioniemi, O.P.5    Pitt, H.A.6
  • 108
    • 0032868050 scopus 로고    scopus 로고
    • Thymidylate synthase: A target for combination therapy and determinant of chemotherapeutic response in colorectal cancer
    • B. Van Triest G. J. Peters 1999 Thymidylate synthase: A target for combination therapy and determinant of chemotherapeutic response in colorectal cancer Oncology 57 179 194
    • (1999) Oncology , vol.57 , pp. 179-194
    • Van Triest, B.1    Peters, G.J.2
  • 109
    • 0036087483 scopus 로고    scopus 로고
    • Thymidylate Synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer
    • C. Aschele S. Lonardi S. Monfardini 2002 Thymidylate Synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer Cancer Treatment Reviews 28 27 47
    • (2002) Cancer Treatment Reviews , vol.28 , pp. 27-47
    • Aschele, C.1    Lonardi, S.2    Monfardini, S.3
  • 111
    • 0028567822 scopus 로고
    • Toxicity, metabolism, DNA incorporation with lack of repair, and lactate production for 1-(2′-fluoro-2′-deoxy-beta-d-arabinofuranosyl)-5- iodouracil in U-937 and MOLT-4 cells
    • R. W. Klecker A. G. Katki J. M. Collins 1994 Toxicity, metabolism, DNA incorporation with lack of repair, and lactate production for 1-(2′-fluoro-2′-deoxy-beta-d-arabinofuranosyl)-5-iodouracil in U-937 and MOLT-4 cells Molecular Pharmacology 46 1204 1209
    • (1994) Molecular Pharmacology , vol.46 , pp. 1204-1209
    • Klecker, R.W.1    Katki, A.G.2    Collins, J.M.3
  • 112
    • 0036010962 scopus 로고    scopus 로고
    • Radiolabeled 2′-fluorodeoxyuracil-beta-d-arabinofuranoside (FAU) and 2′-fluoro-5-methyldeoxyuracil-beta-d-arabinofuranoside (FMAU) as tumor-imaging agents in mice
    • H. Wang P. Oliver L. Nan S. Wang Z. Wang J. K. Rhie 2002 Radiolabeled 2′-fluorodeoxyuracil-beta-d-arabinofuranoside (FAU) and 2′-fluoro-5-methyldeoxyuracil-beta-d-arabinofuranoside (FMAU) as tumor-imaging agents in mice Cancer Chemotherapy and Pharmacology 49 419 424
    • (2002) Cancer Chemotherapy and Pharmacology , vol.49 , pp. 419-424
    • Wang, H.1    Oliver, P.2    Nan, L.3    Wang, S.4    Wang, Z.5    Rhie, J.K.6
  • 115
    • 5144232119 scopus 로고    scopus 로고
    • Distribution of 1-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: Rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase
    • J. L. Eiseman C. Brown-Proctor P. E. Kinahan J. M. Collins L. W. Anderson E. Joseph 2004 Distribution of 1-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: Rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase Clinical Cancer Research 10 6669 6676
    • (2004) Clinical Cancer Research , vol.10 , pp. 6669-6676
    • Eiseman, J.L.1    Brown-Proctor, C.2    Kinahan, P.E.3    Collins, J.M.4    Anderson, L.W.5    Joseph, E.6
  • 118
    • 0036534108 scopus 로고    scopus 로고
    • Thymidylate synthase expression in colorectal cancer: A prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy
    • D. Edler B. Glimelius M. Hallstrom A. Jakobsen P. G. Johnston I. Magnusson 2002 Thymidylate synthase expression in colorectal cancer: A prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy Journal of Clinical Oncology 20 1721 1728
    • (2002) Journal of Clinical Oncology , vol.20 , pp. 1721-1728
    • Edler, D.1    Glimelius, B.2    Hallstrom, M.3    Jakobsen, A.4    Johnston, P.G.5    Magnusson, I.6
  • 122
    • 33845877973 scopus 로고    scopus 로고
    • A gene expression signature predicts survival of patients with stage I non-small cell lung cancer
    • Y. Lu W. Lemon P. Y. Liu Y. Yi C. Morrison P. Yang 2006 A gene expression signature predicts survival of patients with stage I non-small cell lung cancer PLoS Medicine 3 e467
    • (2006) PLoS Medicine , vol.3 , pp. 467
    • Lu, Y.1    Lemon, W.2    Liu, P.Y.3    Yi, Y.4    Morrison, C.5    Yang, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.