Effects of pore size and implant volume of porous hydroxyapatite/collagen (HAp/Col) on bone formation in a rabbit bone defect model

Journal of Medical and Dental Sciences

Volumn 55, Issue 1, 2008, Pages 91-99

  Tsuchiya, Akio ^a   Sotome, Shinichi ^a   Asou, Yoshinori ^a   Kikuchi, Masanori ^b   Koyama, Yoshihisa ^a   Ogawa, Tetsuro ^c   Tanaka, Junzo ^d   Shinomiya, Kenichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

^c PENTAX Corporation   (Japan)

^d TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Bioabsorbability; Bone repair; Hydroxyapatite collagen composite (HAp Col); Nanocomposite; Porous structure

Indexed keywords

COLLAGEN; HYDROXYAPATITE; NANO HYDROXYAPATITE COLLAGEN; NANO-HYDROXYAPATITE-COLLAGEN; NANOCOMPOSITE;

ANIMAL; ANIMAL MODEL; ARTICLE; BIODEGRADABLE IMPLANT; BONE MARROW; BONE REGENERATION; DRUG EFFECT; IMPLANT; PERIOSTEUM; PHYSIOLOGY; POROSITY; RABBIT; RADIOGRAPHY; TIBIA;

ABSORBABLE IMPLANTS; ANIMALS; BONE MARROW; BONE REGENERATION; COLLAGEN; DURAPATITE; IMPLANTS, EXPERIMENTAL; MODELS, ANIMAL; NANOCOMPOSITES; PERIOSTEUM; POROSITY; RABBITS; TIBIA;

EID: 52449131189     PISSN: 13428810     EISSN: 13428810     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Denissen HW, de Groot K. Immediate dental root implants from synthetic dense calcium hydroxyapatite. J Prosthet Dent 1979;42:551-556.
2. LeGeros RZ. Properties of osteoconductive biomaterials: calcium phosphates. Clin Orthop 2002;395:81-98.
3. Bucholz RW. Nonallograft osteoconductive bone graft substitutes. Clin Orthop 2002;395:44-52.
4. Giannoudis RV, Dinopoulos H, Tsiridis E. Bone substitutes: An update. Injury Int J Care Injured 2005;36S:S20-S27.
5. Kikuchi M, Itoh S, Ichinose Set al. Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo. Biomaterials 2001;22:1705-1711.
6. Rhee SH, Suetsugu Y, Tanaka J. Biomimetic configurational arrays of hydroxyapatite nanocrystals on bio-organics. Biomaterials 2001;22:2843-2847.
7. Itoh S, Kikuchi M, Takakuda Ket al. The biocompatibility and osteoconductive activity of a novel hydroxyapatite/collagen composite biomaterial, and its function as a carrier of rhBMP-2. J Biomed Mater Res 2001;54:445-453.
8. Itoh S, Kikuchi M, Takakuda K et al. Implantation study of a novel hydroxyapatite/collagen (HAp/Col) composite into weight-bearing sites of dogs. J Biomed Mater Res 2002;63:507-515.
9. Itoh S, Kikuchi M, Koyama Y et al. Development of an artificial vertebral body using a novel biomaterial, hydroxyapatite/collagen composite. Biomaterials 2002;23:3919-3926.
10. Kikuchi M, Ikoma T, Syoji Det al. Porous body preparation of hydroxyapatite/collagen nanocomposites for bone tissue regeneration. Key Eng Mater 2004;254:561-564.
11. Sotome S, Orii H, Kikuchi M et al. In vivo evaluation of porous hydroxyapatite/collagen composite as a carrier of OP-1 in a rabbit PLF model. Key Eng Mater 2006;309-311:977-980.
12. Underwood E E, Colcord A R, Wangh W C et al. Ceramic Microstructures. Wiley and Sons 1966;p25-52.
13. Underwood E E. Quantitative Sterereology. Addison Wesley1970. Fullman R L. Trans AIME 1953;197:447-452.
14. Ritter H.L, Drake L C. Pore-size distribution in porous materials: Pressure porosimeter and determination of complete macropore-size distributions. Ind. Eng. Chem 1945;17:782-787.
15. Ferretti JL. Peripheral quantitative computed tomography for evaluating structural and mechanical properties of small bone. In: Yuehuei HA, Robert A D. Mechanical testing of bone and the bone-implant interface. Boca Raton FL: CRC press; 1999:385-405.
16. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005;26:5474-5491.
17. Galois L, Mainard D. Bone ingrowth into two porous ceramics with different pore sizes: an experimental study. Acta Orthop Belg 2004;70:598-603.
18. Lu JX, Flautre B, Anselme K et al. Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo. J Mater Sci Mater Med 1999;10:111-120.
19. Flautre B, Descamps M, Delecourt C et al. Porous HA ceramic for bone replacement: role of the pores and interconnections - experimental study in the rabbit. J Mater Sci Mater Med 2001;12:679-682.
20. Tamai N, Myoui A, Tomita T. et al. Novel hydroxyapatite ceramics with an interconnective porous structure exhibit superior osteoconduction in vivo. J Biomed Mater Res 2002;59:110-117.
21. Mastrogiacomo M, Scaglione S, Martinetti R et al. Role of scaffold internal structure on in vivo bone formation macroporous calcium phosphate bioceramics. Biomaterials 2006;27:3230-3237.
22. Aaboe M, Pinholt E M, Hjørting-Hansen E. Unicortical critical size defect of rabbit tibia is larger than 8 mm. J Craniofac Surg. 1994;5:201-203.