Water intoxication induced by low-dose oral cyclophosphamide in a patient with anti-neutrophil cytoplasmic antibody-related glomerulonephritis

NDT Plus

Volumn 1, Issue 5, 2008, Pages 286-288

  Kato, Akihiko ^a   Sugiura, Takeshi ^b   Yamamoto, Tatsuo ^a   Misaki, Taro ^a   Tsuji, Takayuki ^a   Sakao, Yukitoshi ^a   Sakakima, Masaaki ^a   Yasuda, Hideo ^a   Fujigaki, Yoshihide ^a   Hishida, Akira ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SEIREI MIKATAHARA GENERAL HOSPITAL   (Japan)

Author keywords

Chronic kidney disease; Cyclophosphamide; Fluid intake; Symptomatic hyponatraemia

Indexed keywords

CYCLOPHOSPHAMIDE; METHYLPREDNISOLONE; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PREDNISOLONE;

AGED; ANAMNESIS; ARTICLE; BRAIN EDEMA; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DRUG WITHDRAWAL; FEMALE; FLUID INTAKE; GLOMERULONEPHRITIS; GLOMERULUS FILTRATION RATE; HEMORRHAGIC CYSTITIS; HUMAN; HUMAN TISSUE; HYPONATREMIA; KIDNEY BIOPSY; KIDNEY FAILURE; LABORATORY TEST; LOW DRUG DOSE; PRIORITY JOURNAL; WATER INTOXICATION; WATER LOADING;

EID: 52449129051     PISSN: 17530784     EISSN: 17530792     Source Type: Journal    
DOI: 10.1093/ndtplus/sfn076     Document Type: Article

References (9)

1. Webberley MJ, Murray JA. Life-threatening acute hyponatremia induced by low dose cyclophosphamide and indomethacin. Postgrad Med J 1989; 65: 950-952
2. McCarron MO, Wright GD, Roberts SD. Water intoxication after low dose cyclophosphamide. BMJ 1995; 311: 292
3. Spital A, Ristow S. Cyclophosphamide induced water intoxication in a woman with Sjögren's syndrome. J Rheumatol 1997; 24: 2473-2475
4. Salido M, Macarron P, Hernandez-Garcia C et al. Water intoxication induced by low-dose cyclophosphamide in two patients with systemic lupus erythematosus. Lupus 2003; 12: 636-639
5. Imai E, Horio M, Nitta K et al. Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan. Am J Kidney Dis 2007; 50: 927-937
6. DeFronzo RA, Braine H, Colvin M. Water intoxication in man after cyclophosphamide therapy. Time course and relation to drug activation. Ann Intern Med 1973; 78: 861-869
7. Bressler RB, Huston DP. Water intoxication following moderate-dose intravenous cyclophosphamide. Arch Intern Med 1985; 145: 548-549
8. Campbell DM, Atkinson A, Gillis D et al. Cyclophosphamide and water retention: mechanism revisited. J Pediatr Endocrinol Metab 2000; 13: 673-675
9. Haubitz M, Bohnenstengel F, Brunkhorst R et al. Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency. Kidney Int 2002; 61: 1495-1501