A new strategy to decrease risk of resistance emerging during therapy switching in HIV treatment

Proceedings of the American Control Conference

Volumn , Issue , 2008, Pages 2112-2117

  Luo, Rutao ^a   Zurakowski, Ryan ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNING; CHEMOTHERAPY; DRUG DELIVERY; DRUG DOSAGE; RESERVOIRS (WATER);

DOMINANT SPECIES; HIGHLY ACTIVE ANTI-RETROVIRAL THERAPY; HIV INFECTIONS; NEW STRATEGY; RESISTANT STRAINS; SIMPLE MODELING; SWITCHING STRATEGIES;

PATIENT TREATMENT;

EID: 52449128028     PISSN: 07431619     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ACC.2008.4586804     Document Type: Conference Paper

References (10)

1. P. G. Yeni, S. M. Hammer, C. C. J. Carpenter, D. A. Cooper, M. A. Fischl, J. M. Gatell, B. G. Gazzard, M. S. Hirsch, D. M. Jacobsen, D. A. Katzenstein, J. S. G. Montaner, D. D. Richman, M. S. Saag, M. Schechter, R. T. Schooley, M. A. Thompson, S. Vella, and P. A. Volberding, "Antiretroviral treatment for adult hiv infection in 2002: updated recommendations of the international aids society-usa panel," Journal of the American Medical Association, vol. 288, pp. 222-235, 2002.
2. S. C. Knight, S. E. Macatonia, and S. Patterson, "Hiv i infection of dendritic cells," International Reviews of Immunology, vol. 6, no. 2-3, pp. 163-175, 1990.
3. D. Finzi, M. Hermankova, T. Pierson, L. M. Carruth, C. Buck, R. E. Chaisson, T. C. Quinn, K. Chadwick, J. Margolick, R. Brookmeyer, J. Gallant, M. Markowitz, D. D. Ho, D. D. Richman, and R. F. Siliciano, "Identification of a reservoir for hiv-1 in patients on highly active antiretroviral therapy," Science, vol. 278, pp. 1295-1300, 1997.
4. T.W. Chun, L. Carruth, D. Finzi, X. Shen, J. A. DiGiuseppe, H. Taylor, M. Hermankova, K. Chadwick, J. Margolick, T. C. Quinn, Y. H. Kuo, R. Brookmeyer, M. A. Zeiger, P. Barditch-Crovo, and R. F. Siliciano, "Quantification of latent tissue reservoirs and total body viral load in hiv-1 infection," Nature, vol. 387, pp. 183-188, 1997.
5. T. Pierson, T. L. Hoffman, J. Blankson, D. Finzi, K. Chadwick, J. B. Margolick, C. Buck, J. D. Siliciano, R. W. Doms, and R. F. Siliciano, "Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1," Journal of Virology, vol. 74, pp. 7824-7833, 2000.
6. S. Bonhoeffer and M. A. Nowak, "Pre-existence and emergence of drug resistance in hiv-1 infection," Proc R Soc Lond B Biol Sci, vol. 264, no. 1382, pp. 631-637, 1997.
7. R. M. DAmato, R. T. DAquila, and L. M. Wein, "Management of antiretroviral therapy for hiv infection: modeling when to change therapy," Antiviral Therapy, vol. 3, no. 3, pp. 147-158, 1998.
8. R. Zurakowski and D. Wodarz, "Treatment interruptions to decrease risk of resistance emerging during therapy switching in hiv treatment," CDC, p. to appear, 2007.
9. R. Ribeiro and S. Bonhoeffer, "Production of resistant hiv mutants during antiretroviral therapy," Proceedings of the National Academy of Sciences USA, vol. 97, no. 14, pp. 7681-7686, 2000.
10. F. Aiuti and I. Mezzaroma, "Failure to reconstitute cd4+ t-cells despite suppression of hiv replication under haart," AIDS Rev, vol. 8, no. 2, pp. 88-97, 2006.