Hypercoagulability in cats with cardiomyopathy

Journal of Veterinary Internal Medicine

Volumn 22, Issue 3, 2008, Pages 546-552

  Stokol, Tracy ^a   Brooks, M ^a   Rush, J E ^b   Rishniw, M ^a   Erb, H ^a   Rozanski, E ^b   Kraus, M S ^a   Gelzer, A L ^a  

^a Department of Obstetrics Gynecology   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Aortic thromboembolism; D dimer; Endothelial injury; Hemostasis; Spontaneous echocardiographic contrast; Thrombin antithrombin complexes

Indexed keywords

ANIMALIA; FELIDAE;

ANTIGEN; ANTITHROMBIN III; ANTITHROMBIN III PROTEASE COMPLEX; ANTITHROMBIN III-PROTEASE COMPLEX; BLOOD CLOTTING FACTOR 8; FIBRIN; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D; FIBRINOGEN; PEPTIDE HYDROLASE; VON WILLEBRAND ANTIGEN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; CARDIOMYOPATHY; CAT; CAT DISEASE; FEMALE; MALE; METABOLISM; PATHOLOGY; RISK FACTOR; THROMBOPHILIA; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS; ANTITHROMBIN III; CARDIOMYOPATHIES; CAT DISEASES; CATS; ENDOTHELIUM, VASCULAR; FACTOR VIII; FEMALE; FIBRIN; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; MALE; PEPTIDE HYDROLASES; RISK FACTORS; THROMBOPHILIA;

EID: 52449110536     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2008.0098.x     Document Type: Article

References (45)

1. Rush JE, Freeman LM, Fenollosa NK, et al. Population and survival characteristics of cats with hypertrophic cardiomyopathy: 260 cases (1990-1999). J Am Vet Med Assoc 2002;220:202-207.
2. Smith SA, Tobias AH. Feline arterial thromboembolism: An update. Vet Clin North Am Small Anim Pract 2004;34:1245-1271.
3. Laste NJ, Harpster NK. A retrospective study of 100 cases of feline distal aortic thromboembolism: 1977-1993. J Am Anim Hosp Assoc 1995;31:492-500.
4. Norris CR, Griffey SM, Samii VF. Pulmonary thromboembolism in cats: 29 cases (1987-1997). J Am Vet Med Assoc 1999;215:1650-1654.
5. Liu SK. Acquired cardiac lesions leading to congestive heart failure in the cat. Am J Vet Res 1970;31:2071-2088.
6. Schafer AI. The hypercoagulable states. Ann Intern Med 1985;102:814-828.
7. Eilertsen KE, Osterud B. Tissue factor: (Pathophysiology and cellular biology. Blood Coagul Fibrinolysis 2004;15:521-538.
8. Hathcock JJ. Flow effects on coagulation and thrombosis. Arterioscler Thromb Vasc Biol 2006;26:1729-1737.
9. Schober KE, Maerz I. Assessment of left atrial appendage flow velocity and its relation to spontaneous echocardiographic contrast in 89 cats with myocardial disease. J Vet Intern Med 2006;20:120-130.
10. Fatkin D, Feneley M. Stratification of thromboembolic risk of atrial fibrillation by transthoracic echocardiography and transesophageal echocardiography: The relative role of left atrial appendage function, mitral valve disease, and spontaneous echocardiographic contrast. Prog Cardiovasc Dis 1996;39:57-68.
11. Siostrzonek P, Koppensteiner R, Gossinger H, et al. Hemodynamic and hemorheologic determinants of left atrial spontaneous echo contrast and thrombus formation in patients with idiopathic dilated cardiomyopathy. Am Heart J 1993;125:430-434.
12. Fareed J, Hoppensteadt DA, Leya F, et al. Useful laboratory tests for studying thrombogenesis in acute cardiac syndromes. Clin Chem 1998;44:1845-1853.
13. Boisclair MD, Ireland H, Lane DA. Assessment of hypercoagulable states by measurement of activation fragments and peptides. Blood Rev 1990;4:25-40.
14. Yamamoto K, Ikeda U, Furuhashi K, et al. The coagulation system is activated in idiopathic cardiomyopathy. J Am Coll Cardiol 1995;25:1634-1640.
15. Turchetti V, Bellini MA, Ricci D, et al. Spontaneous echo-contrast as an in vivo indicator of Theological imbalance in dilatative cardiomyopathy. Clin Hemorheol Microcirc 2001;25:119-125.
16. Riza Erbay A, Turhan H, Aksoy Y, et al. Activation of co-agulation system in dilated cardiomyopathy: Comparison of patients with and without left ventricular thrombus. Coron Artery Dis 2004;15:265-268.
17. Bedard C, Lanevschi-Pietersma A, Dunn M. Evaluation of coagulation markers in the plasma of healthy cats and cats with asymptomatic hypertrophic cardiomyopathy. Vet Clin Pathol 2007;36:167-172.
18. Brazzell JL, Borjesson DL. Evaluation of plasma antithrombin activity and D-dimer concentration in populations of healthy cats, clinically ill cats, and cats with cardiomyopathy. Vet Clin Pathol 2007;36:79-84.
19. Cattaneo M, Mannucci PM. Predictive value of coagulation tests in arterial thrombosis. Ric Clin Lab 1988;18:1-7.
20. Lee KW, Blann AD, Lip GY. Plasma markers of endothelial damage/dysfunction, inflammation and thrombogenesis in relation to TIMI risk stratification in acute coronary syndromes. Thromb Haemost 2005;94:1077-1083.
21. O'Donnell J, Laffan M. Elevated plasma factor VIII levels - A novel risk factor for venous thromboembolism. Clin Lab 2001;47:1-6.
22. Green RA. Pathophysiology of antithrombin III deficiency. Vet Clin North Am Small Anim Pract 1988;18:95-104.
23. Kumagai K, Fukuchi M, Ohta J, et al. Expression of the von Willebrand factor in atrial endocardium is increased in atrial fibrillation depending on the extent of structural remodeling. Circ J 2004;68:321-327.
24. Abbott JA, MacLean HN. Two-dimensional echocardiographic assessment of the feline left atrium. J Vet Intern Med 2006;20:111-119.
25. Thomas JS, Green RA. Clotting times and antithrombin III activity in cats with naturally developing diseases: 85 cases (1984-1994). J Am Vet Med Assoc 1998;213:1290-1295.
26. Hedlund LJ, Carlson JE, Urness M, et al. Urokinase-mediated thrombolysis: A dose-response relationship in cats. Work in progress. J Vasc Interv Radiol 1991;2:349-352.
27. Alwood AJ, Downend AB, Brooks MB, et al. Anticoagulant effects of low-molecular-weight heparins in healthy cats. J Vet Intern Med 2007;21:378-387.
28. Clauss A. Gerinnungsphysiologische schnellmethode zur bestimmung des fibrinogens (Rapid physiological coagulation method in determination of fibrinogen). Acta Haematol 1957;17:237-246.
29. Gaffney PJ, Wong MY. Collaborative study of a proposed international standard for plasma fibrinogen measurement. Thromb Haemost 1992;68:428-432.
30. Stokol T, Brooks MB, Erb HN. Effect of citrate concentration on coagulation test results in dogs. J Am Vet Med Assoc 2000;217:1672-1677.
31. Benson RE, Catalfamo JL, Dodds WJ. A multispecies enzyme-linked immunosorbent assay for von Willebrand's factor. J Lab Clin Med 1992;119:420-427.
32. Stokol T, Erb HN, De Wilde L, et al. Evaluation of latex agglutination kits for detection of fibrin(ogen) degradation products and D-dimer in healthy horses and horses with severe colic. Vet Clin Pathol 2005;34:375-382.
33. Ravanat C, Freund M, Dol F, et al. Cross-reactivity of human molecular markers for detection of prethrombotic states in various animal species. Blood Coagul Fibrinol 1995;6:446-455.
34. Yasaka M, Beppu S. Hypercoagulability in the left atrium: Part II. Coagulation factors. J Heart Valve Dis 1993;2:25-34; discussion 35-36.
35. Peverill RE, Harper RW, Gan TE, et al. Increased left atrial thrombin generation in mitral stenosis is not reflected in arterial prothrombin fragment 1 + 2 levels. Clin Sci (London) 2000;98:501-506.
36. Helenski CA, Ross JN Jr. Platelet aggregation in feline cardiomyopathy. J Vet Intern Med 1987;1:24-28.
37. Jacoby RC, Owings JT, Ortega T, et al. Biochemical basis for the hypercoagulable state seen in Cushing syndrome; discussion 1006-7. Arch Surg 2001;136:1003-1006.
38. Stokol T. Plasma D-dimer for the diagnosis of thrombo-embolic disorders in dogs. Vet Clin North Am Small Anim Pract 2003;33:1419-1435.
39. Vaya A, Mira Y, Martinez M, et al. Biological risk factors for deep vein trombosis. Clin Hemorheol Microcirc 2002;26:41-53.
40. Scott-Moncrieff J, Treadwell NG, McCullough SM, et al. Hemostatic abnormalities in dogs with primary immune-mediated hemolytic anemia. J Am Anim Hosp Assoc 2001;37:220-227.
41. Weiss DJ. Clinical hemorrheology. In: Feldman BF, Zinkl JG, Jain NC, eds. Schalm's Veterinary Hematology. Baltimore, MD: Lippincott Williams & Wilkins; 2000:57-60.
42. Begbie M, Notley C, Tinlin S, et al. The Factor VIII acute phase response requires the participation of NFkappaB and C/EBP. Thromb Haemost 2000;84:216-222.
43. Sakurai K, Hirai T, Nakagawa K, et al. Left atrial appendage function and abnormal hypercoagulability in patients with atrial flutter. Chest 2003;124:1670-1674.
44. Nakagawa K, Hirai T, Shinokawa N, et al. Aortic spontaneous echocardiographic contrast and hemostatic markers in patients with nonrheumatic atrial fibrillation. Chest 2002;121:500-505.
45. Tsai LM, Chen JH, Tsao CJ. Relation of left atrial spontaneous echo contrast with prethrombotic state in atrial fibrillation associated with systemic hypertension, idiopathic dilated cardiomyopathy, or no identifiable cause (lone). Am J Cardiol 1998;81:1249-1252.