Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data?

AAPS Journal

Volumn 4, Issue 4, 2002, Pages

  Ito, Kiyomi ^a   Chiba, Koji ^p   Horikawa, Masato ^b   Ishigami, Michi ^c   Mizuno, Naomi ^d   Aoki, Jun ^e   Gotoh, Yasumasa ^f   Iwatsubo, Takafumi ^g   Kanamitsu, Shin Ichi ^h   Kato, Motohiro ⁱ   Kawahara, Lichiro ^j   Niinuma, Kayoko ^c   Nishino, Akiko ^k   Sato, Norihito ^l   Tsukamoto, Yuko ^m   Ueda, Kaoru ⁿ   Itoh, Tomoo ^a   Sugiyama, Yuichi ^o  

^a KITASATO UNIVERSITY   (Japan)

^b NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

^c DAIICHI SANKYO CO   (Japan)

^d Mitsubishi Tokyo Pharmaceuticals Inc   (Japan)

^e Mitsui Pharmaceuticals Inc   (Japan)

^f KISSEI PHARMACEUTICAL CO LTD   (Japan)

^g ASTELLAS PHARMA INC   (Japan)

^h OTSUKA PHARMACEUTICAL CO LTD   (Japan)

ⁱ CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^j BAYER YAKUHIN LTD   (Japan)

^k NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^l SHIONOGI AND CO LTD   (Japan)

^m NIPPON ROCHE RESEARCH CENTER   (Japan)

ⁿ Grelan Pharmaceutical Co Ltd

^o UNIVERSITY OF TOKYO   (Japan)

^p University of Tokyo ^*

more..

Author keywords

Drug interaction; Metabolism; Quantitative prediction

Indexed keywords

CYTOCHROME P450; ENZYME INHIBITOR;

ARTICLE; BINDING COMPETITION; DRUG ANTAGONISM; DRUG INTERACTION; ENZYME SPECIFICITY; HUMAN; KINETICS;

BINDING, COMPETITIVE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME INHIBITORS; HUMANS; KINETICS; SUBSTRATE SPECIFICITY;

EID: 52449091109     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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