Mechanisms of action of antithymocyte globulin: Old dogs with new tricks!

Leukemia and Lymphoma

Volumn 49, Issue 9, 2008, Pages 1664-1667

  Mohty, Mohamad ^a,b   Gaugler, Beatrice ^c  

^a HÔTEL DIEU   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c UNIVERSITÉ DE FRANCHE COMTÉ   (France)

Author keywords

Dendritic cells; Immunosuppression; Polyclonal antibodies; Regulatory T cells; T cell depletion; Transplantation

Indexed keywords

ALEMTUZUMAB; B7 ANTIGEN; CD123 ANTIGEN; CD30 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR6; FAS ANTIGEN; HLA DR ANTIGEN; INDOLEAMINE 2,3 DIOXYGENASE; INTEGRIN; INTERLEUKIN 2 RECEPTOR ALPHA; MEMBRANE RECEPTOR; SYNDECAN 1; THYMOCYTE ANTIBODY; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR NFAT;

B LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CELL ADHESION; CELL INFILTRATION; DENDRITIC CELL; DOWN REGULATION; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; MACROPHAGE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; T CELL DEPLETION; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

ANTIGENS, CD; ANTILYMPHOCYTE SERUM; DENDRITIC CELLS; HUMANS; IMMUNOSUPPRESSION; LYMPHOCYTES;

EID: 52349121486     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190802163321     Document Type: Review

References (14)

1. Mohty, M. (2007) Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond. Leukemia, 21, pp. 1387-1394.
2. Preville, X., Flacher, M., LeMauff, B., Beauchard, S., Davelu, P. Tiollier, J. et al. (2001) Mechanisms involved in antithymocyte globulin immunosuppressive activity in a nonhuman primate model. Transplantation, 71, pp. 460-468.
3. Bonnefoy-Berard, N. and Revillard, J. P. (1996) Mechanisms of immunosuppression induced by antithymocyte globulins and OKT3. J Heart Lung Transplant, 15, pp. 435-442.
4. Michallet, M. C., Preville, X., Flacher, M., Fournel, S., Genestier, L. and Revillard, J. P. (2003) Functional antibodies to leukocyte adhesion molecules in antithymocyte globulins. Transplantation, 75, pp. 657-662.
5. Chappell, D., Beiras-Fernandez, A., Hammer, C. and Thein, E. (2006) In vivo visualization of the effect of polyclonal antithymocyte globulins on the microcirculation after ischemia/reperfusion in a primate model. Transplantation, 81, pp. 552-558.
6. Shah, A., Nadasdy, T., Arend, L., Brennan, J., Leong, N. Coppage, M. et al. (2004) Treatment of C4d-positive acute humoral rejection with plasmapheresis and rabbit polyclonal antithymocyte globulin. Transplantation, 77, pp. 1399-1405.
7. Bourdage, J. S. and Hamlin, D. M. (1995) Comparative polyclonal antithymocyte globulin and antilymphocyte/antilymphoblast globulin anti-CD antigen analysis by flow cytometry. Transplantation, 59, pp. 1194-1200.
8. Zand, M. S., Vo, T., Huggins, J., Felgar, R., Liesveld, J. Pellegrin, T. et al. (2005) Polyclonal rabbit antithymocyte globulin triggers B-cell and plasma cell apoptosis by multiple pathways. Transplantation, 79, pp. 1507-1515.
9. Monti, P., Allavena, P., Di Carlo, V and Piemonti, L. (2003) Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells. Int Immunopharmacol, 3, pp. 189-196.
10. Gillet-Hladky, S., de Carvalho, C. M., Bernaud, J., Bendahou, C., Bloy, C. and Rigal, D. (2006) Rabbit antithymocyte globulin inhibits monocyte-derived dendritic cells maturation in vitro and polarizes monocyte-derived dendritic cells towards tolerogenic dendritic cells expressing indoleamine 2,3-dioxygenase. Transplantation, 82, pp. 965-974.
11. Bluestone, J. A. (2005) Regulatory T-cell therapy: Is it ready for the clinic?. Nat Rev Immunol, 5, pp. 343-349.
12. Lopez, M., Clarkson, M. R., Albin, M., Sayegh, M. H. and Najafian, N. (2006) A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells. J Am Soc Nephrol, 17, pp. 2844-2853.
13. Feng, X., Kajigaya, S., Solomou, E. E., Keyvanfar, K., Xu, X. Raghavachari, N. et al. (2008) Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25 high FOXP3+ regulatory T cells in vitro. Blood, 111, pp. 3675-3683.
14. Lowsky, R., Takahashi, T., Liu, Y. P., Dejbakhsh-Jones, S., Grumet, F. C. Shizuru, J. A. et al. (2005) Protective conditioning for acute graft-versus-host disease. N Engl J Med, 353, pp. 1321-1331.