-
1
-
-
20144385196
-
Design of HIV-1 protease inhibitors active on multidrug-resistant virus
-
Surleraux DL, de Kock HA, Verschueren WG et al. Design of HIV-1 protease inhibitors active on multidrug-resistant virus. J Med Chem, 2005, 48, 1965-1973.
-
(2005)
J Med Chem
, vol.48
, pp. 1965-1973
-
-
Surleraux, D.L.1
de Kock, H.A.2
Verschueren, W.G.3
-
2
-
-
20144382495
-
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor
-
Surleraux DL, Tahri A, Verschueren WG et al. Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor. J Med Chem, 2005, 48, 1813-1822.
-
(2005)
J Med Chem
, vol.48
, pp. 1813-1822
-
-
Surleraux, D.L.1
Tahri, A.2
Verschueren, W.G.3
-
3
-
-
6344231715
-
Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor
-
King NM, Prabu-Jeyabalan M, Nalivaika EA et al. Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor. J Virol, 2004, 78, 12012-12021.
-
(2004)
J Virol
, vol.78
, pp. 12012-12021
-
-
King, N.M.1
Prabu-Jeyabalan, M.2
Nalivaika, E.A.3
-
4
-
-
34047207229
-
Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials
-
Clotet B, Bellos N, Molina JM et al. Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials. Lancet, 2007, 369, 1169-1178.
-
(2007)
Lancet
, vol.369
, pp. 1169-1178
-
-
Clotet, B.1
Bellos, N.2
Molina, J.M.3
-
5
-
-
33746576313
-
Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: An analysis of combined data from two randomised open-label trials
-
Hicks CB, Cahn P, Cooper DA et al. Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: an analysis of combined data from two randomised open-label trials. Lancet, 2006, 368, 466-475.
-
(2006)
Lancet
, vol.368
, pp. 466-475
-
-
Hicks, C.B.1
Cahn, P.2
Cooper, D.A.3
-
6
-
-
22444439664
-
Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures
-
Johnson M, Grinsztejn B, Rodriguez C et al. Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures. AIDS, 2005, 19, 685-694.
-
(2005)
AIDS
, vol.19
, pp. 685-694
-
-
Johnson, M.1
Grinsztejn, B.2
Rodriguez, C.3
-
7
-
-
0036499067
-
Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients
-
Benson CA, Deeks SG, Brun SC et al. Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients. J Infect Dis, 2002, 185, 599-607.
-
(2002)
J Infect Dis
, vol.185
, pp. 599-607
-
-
Benson, C.A.1
Deeks, S.G.2
Brun, S.C.3
-
8
-
-
42049111688
-
Efficacy and safety of darunavir/ritonavir versus lopinavir/ritonavir in ARV treatment-naive HIV-1-infected patients at week 48: ARTEMIS
-
Chicago, September, Abstract H-718b
-
DeJesus E, Ortiz R, Khanlou H, et al. Efficacy and safety of darunavir/ritonavir versus lopinavir/ritonavir in ARV treatment-naive HIV-1-infected patients at week 48: ARTEMIS. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, September 2007. Abstract H-718b.
-
(2007)
47th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
DeJesus, E.1
Ortiz, R.2
Khanlou, H.3
-
9
-
-
49149127276
-
Warning on hepatotoxicity of darunavir
-
Vispo E. Warning on hepatotoxicity of darunavir. AIDS Rev, 2008, 10, 63.
-
(2008)
AIDS Rev
, vol.10
, pp. 63
-
-
Vispo, E.1
-
10
-
-
41449098109
-
Resistance profile of darunavir: Combined 24-week results from the POWER trials
-
de Meyer S, Vangeneugden T, van Baelen BG et al. Resistance profile of darunavir: combined 24-week results from the POWER trials. AIDS Res Hum Retroviruses 2008, 24, 379-388.
-
(2008)
AIDS Res Hum Retroviruses
, vol.24
, pp. 379-388
-
-
de Meyer, S.1
Vangeneugden, T.2
van Baelen, B.G.3
-
11
-
-
34247869104
-
Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials
-
Hill A, Moyle G. Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials. HIV Med, 2007, 8, 259-264.
-
(2007)
HIV Med
, vol.8
, pp. 259-264
-
-
Hill, A.1
Moyle, G.2
-
12
-
-
31344465969
-
Practical perspectives on the use of tipranavir in combination with other medications: Lessons learned from pharmacokinetic studies
-
Boffito M, Maitland D, Pozniak A. Practical perspectives on the use of tipranavir in combination with other medications: lessons learned from pharmacokinetic studies. J Clin Pharmacol, 2006, 46, 130-139.
-
(2006)
J Clin Pharmacol
, vol.46
, pp. 130-139
-
-
Boffito, M.1
Maitland, D.2
Pozniak, A.3
-
13
-
-
25144487293
-
Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir
-
Doyon L, Tremblay S, Bourgon L et al. Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir. Antiviral Res, 2005, 68, 27-35.
-
(2005)
Antiviral Res
, vol.68
, pp. 27-35
-
-
Doyon, L.1
Tremblay, S.2
Bourgon, L.3
-
14
-
-
33845925741
-
Food and Drug Administration analysis of tipranavir clinical resistance in HIV-1-infected treatment-experienced patients
-
Naeger LK, Struble KA. Food and Drug Administration analysis of tipranavir clinical resistance in HIV-1-infected treatment-experienced patients. AIDS, 2007, 21, 179-185.
-
(2007)
AIDS
, vol.21
, pp. 179-185
-
-
Naeger, L.K.1
Struble, K.A.2
-
15
-
-
33644792666
-
Update of the drug resistance mutations in HIV-1: Fall 2005
-
Johnson VA, Brun-Vezinet F, Clotet B et al. Update of the drug resistance mutations in HIV-1: Fall 2005. Top HIV Med, 2005, 13, 125-131.
-
(2005)
Top HIV Med
, vol.13
, pp. 125-131
-
-
Johnson, V.A.1
Brun-Vezinet, F.2
Clotet, B.3
-
16
-
-
43549093736
-
Evidence for different susceptibility to tipranavir and darunavir in patients infected with distinct HIV-1 subtypes
-
Poveda E, de Mendoza C, Parkin N et al. Evidence for different susceptibility to tipranavir and darunavir in patients infected with distinct HIV-1 subtypes. AIDS, 2008, 22, 611-616.
-
(2008)
AIDS
, vol.22
, pp. 611-616
-
-
Poveda, E.1
de Mendoza, C.2
Parkin, N.3
-
17
-
-
44949138344
-
Successful use of a tipranavir/ritonavir-based antiretroviral regimen following development of viral resistance to darunavir
-
Pierone G, Jr, Urban T, Martin A et al. Successful use of a tipranavir/ritonavir-based antiretroviral regimen following development of viral resistance to darunavir. HIV Clin Trials, 2008, 9, 140-141.
-
(2008)
HIV Clin Trials
, vol.9
, pp. 140-141
-
-
Pierone Jr, G.1
Urban, T.2
Martin, A.3
-
18
-
-
34347354196
-
Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial
-
Lazzarin A, Campbell T, Clotet B et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007, 370, 39-48.
-
(2007)
Lancet
, vol.370
, pp. 39-48
-
-
Lazzarin, A.1
Campbell, T.2
Clotet, B.3
-
19
-
-
34347327010
-
Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
-
Madruga JV, Cahn P, Grinsztejn B et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007, 370, 29-38.
-
(2007)
Lancet
, vol.370
, pp. 29-38
-
-
Madruga, J.V.1
Cahn, P.2
Grinsztejn, B.3
-
20
-
-
52249101509
-
-
Haubrich R, Cahn P, Grinsztejn B et al.; on behalf of the DUET-1 study group DUET-1: week-48 results of a phase III randomized double-blind trial to evaluate the efficacy and safety of TMC125 vs placebo in 612 treatment-experienced HIV-1 infected patients. 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 2008. Abstract 790.
-
Haubrich R, Cahn P, Grinsztejn B et al.; on behalf of the DUET-1 study group DUET-1: week-48 results of a phase III randomized double-blind trial to evaluate the efficacy and safety of TMC125 vs placebo in 612 treatment-experienced HIV-1 infected patients. 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 2008. Abstract 790.
-
-
-
-
21
-
-
52249087534
-
-
Johnson M, Campbell T, Clotet B et al.; on behalf of the DUET-2 study group. DUET-2: week-48 results of a phase III randomized double-blind trial to evaluate the efficacy and safety of TMC125 vs placebo in 591 treatment-experienced HIV-1-infected patients. 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 2008. Abstract 791.
-
Johnson M, Campbell T, Clotet B et al.; on behalf of the DUET-2 study group. DUET-2: week-48 results of a phase III randomized double-blind trial to evaluate the efficacy and safety of TMC125 vs placebo in 591 treatment-experienced HIV-1-infected patients. 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 2008. Abstract 791.
-
-
-
-
22
-
-
42549140294
-
Impact of baseline NNRTI mutations on the virological response to TMC125 in the Phase III clinical trials DUET-1 and DUET-2
-
Barbados, June, Abstract 32
-
Vingerhoets J, Buelens A, M et al. Impact of baseline NNRTI mutations on the virological response to TMC125 in the Phase III clinical trials DUET-1 and DUET-2. XVI International HIV Drug Resistance Workshop, Barbados, June 2007. Abstract 32.
-
(2007)
XVI International HIV Drug Resistance Workshop
-
-
Vingerhoets, J.1
Buelens, A.M.2
-
24
-
-
52249114260
-
An update of the list of NNRTI mutations associated with decreased virological response to etravirine: Multivariate analysis on the pooled DUET-1 and DUET-2 clinical trial data
-
Sitges, June, Abstract 24
-
Vingerhoets J, Peeters M, Azijn H et al. An update of the list of NNRTI mutations associated with decreased virological response to etravirine: multivariate analysis on the pooled DUET-1 and DUET-2 clinical trial data. XVIIth International HIV Drug Resistance Workshop, Sitges, June 2008. Abstract 24.
-
(2008)
XVIIth International HIV Drug Resistance Workshop
-
-
Vingerhoets, J.1
Peeters, M.2
Azijn, H.3
-
25
-
-
52249114466
-
-
Peeters M, Nijs S, Vingerhoets J et al. Determination of phenotypic clinical cut-offs for etravirine: pooled week 24 results of the DUET-1 and DUET-2 trials. XVIIth International HIV Drug Resistance Workshop, Sitges, June 2008. Abstract 121.
-
Peeters M, Nijs S, Vingerhoets J et al. Determination of phenotypic clinical cut-offs for etravirine: pooled week 24 results of the DUET-1 and DUET-2 trials. XVIIth International HIV Drug Resistance Workshop, Sitges, June 2008. Abstract 121.
-
-
-
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