The involvement of different mobile LINE copies of blood plasma and extrachromosomal DNA of liver cells in systemic adaptive response

Annals of the New York Academy of Sciences

Volumn 1137, Issue , 2008, Pages 66-72

  Sherlina, Sophiya S ^a   Vladimirov, Viktor G ^a  

^a Scientific Research Institute of Military Medicine DoD RF   (Russian Federation)

Author keywords

Blood plasma; Extracellular DNA; Extrachromosomal DNA; Hepatocyte; Irradiation; LINE DNA; Stress

Indexed keywords

EXTRACHROMOSOMAL DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; CELLULAR STRESS RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DNA CONTENT; ELECTROPHORESIS; GENE TRANSFER; IMMOBILIZED CELL; IONIZING RADIATION; LIVER CELL; LONG INTERSPERSED REPEAT; MALE; NONHUMAN; PLASMA; RAT;

EID: 52249098862     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1448.048     Document Type: Conference Paper

References (11)

1. Zinchenko, V.A. & L.I. Chaschina. 2005. Possible mechanisms of stability of tumoral cells to both beam and chemotherapy. Biopolymers and Cell 21 : 473 484.
2. Marles, B. et al. 1997. Low-dose hypersensitivity and increased radioresistancy in mammalian cells. Int. J. Radiat. Biol. 71 : 721 735.
3. Glebov, A.N. & V.V. Sintchuk. 2006. Prooxidant-antioxidant state of organism under the oxidative stress under the condition of correction of L-arginin-NO system. Bull. Exp. Biol. Med. 131 : 368 370 in Russian & M.E. Greenberg. 1990. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4 : 477 485.
4. Liebermann, D.A. & B. Hoffman. 1994. Differentiation primary response genes and protooncogenes as positive and negative regulators of terminal hematopoietic cell differentiation. Stem Cells (Dayt.) 12 : 352 369.
5. Sherlina, S.S. et al. 1989. The DNA analysis of blood plasma as a test of early diagnosis of radiation damage. The 1-st All-Union Radiobiological Congress. Thesis. Acad. Sci. Putschino. 3 : 680 681 in Russian et al. 1993. Interaction of natural killer of the human being with cells-targets of line K562 and its sublines described by multiple drugs resistance. Bull. Exp. Biol. Med. 56 : 616 618 in Russian & A.S. Belokchvostov. 1995. The activation of mobile genetic LINE-elements at gamma-irradiation. The II-nd International Symposium. Mechanisms of action of super low doses. Thesis. Moscow in Russian 1990. Extrachromosomal circular DNA and genomic sequence plasticity in eukaryotic cells. Mutat. Res. 237 : 271 292.
6. Gogvadze, E.V. et al. 2005. Multiple templates switches on LINE-directed reverse transcription: the most probable mechanism of formation for the double and triple chimerical retroelements in mammals. Bioorgan. Chem. 31 : 81 92 in Russian & A. Gabriel. 1996. Retrotransposon revers-transcriptase-mediated repair of chromosomal breaks. Nature 383 : 641 644.
7. Kazanskij, D.E. et al. 1998. Functional properties of the T-lymphocytes of a liver of a mice immunisated with alloantigen in vivo. Mol. Biol. 32 : 1036 1043 in Russian & J. Doli. 1979. A rapid alkaline extraction procedure for screening plasmid DNA. Nucl. Acid. Res. 7 : 1513 1523.
8. Maniatis, T. et al. 1982. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY.
9. Vladimirov V.G. & S.S. Sherlina. 2002. Influence of exposure to extreme factors of various nature on distribution of repeating sequences in the extracellular DNA. Radiation Biology Radioecology 42 : 754 758 in Russian 2006. Instability genome among descendants of the irradiated parents: the facts and their interpretation. Genetics 42 : 1335 1347 in Russian et al. 1989. Reversion to normal phenotype induced by SV40 in spontaneously transformed Chinese hamster cells. Cancer Genet. Cytogenet. 37 : 39 47.
10. Matzke, M.A. & L.A. Birchler. 2005. RNAi-mediated pathways in the nucleus. Nat. Rev. Genet. 6 : 24 35.
11. Rasin, S.V. 2006. The spatial organization of the eukaryotic genome and work of the epigenetic mechanisms. Genetics 42 : 1605 1614 in Russian Electrophoregram of total echDNA of liver cells (1-4) and ecDNA of blood plasma (5-8) of animals irradiated (lanes 1 and 5); subsequently immobilized and irradiated (lanes 2 and 6); intact (lanes 3 and 7); and immobilized (lanes 4 and 8).