Angiotropism is an independent predictor of local recurrence and in-transit metastasis in primary cutaneous melanoma

American Journal of Surgical Pathology

Volumn 32, Issue 9, 2008, Pages 1396-1403

  Van Es, Simone L ^a   Colman, Marjorie ^a   Thompson, John F ^a,b   McCarthy, Stanley W ^a   Scolyer, Richard A ^a,b  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Angiotropism; Extravascular migratory metastasis; Intransit metastasis; Local recurrence; Melanoma; Pericytic location; Prognosis; Skin

Indexed keywords

ADULT; AGED; ANGIOTROPISM; ARTICLE; CANCER RECURRENCE; CANCER REGRESSION; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MELANOMA; METASTASIS; MITOSIS INDEX; PRIMARY TUMOR; SKIN TUMOR; SKIN ULCER; CANCER INVASION; CELL MOTION; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; PATHOLOGY; TUMOR RECURRENCE;

ADULT; AGED; AGED, 80 AND OVER; CELL MOVEMENT; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MELANOMA; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; SKIN NEOPLASMS;

EID: 52149123499     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181753a8e     Document Type: Article

References (29)

1. Azzola MF, Shaw HM, Thompson JF, et al. Tumor mitotic rate is a more powerful prognostic indicator than ulceration in patients with primary cutaneous melanoma: an analysis of 3661 patients from a single center. Cancer. 2003;97:1488-1498.
2. Baer SC, Schultz D, Synnestvedt M, et al. Desmoplasia and neurotropism. Prognostic variables in patients with stage I melanoma. Cancer. 1995;76:2242-2247.
3. Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol. 2001;19:3622-3634.
4. Barnhill R, Dy K, Lugassy C. Angiotropism in cutaneous melanoma: a prognostic factor strongly predicting risk for metastasis. J Invest Dermatol. 2002;119:705-706.
5. Barnhill R, Piepkorn M, Busam K. Pathology of Melanocytic Nevi and Malignant Melanoma. New York: Springer-Verlag; 2004.
6. Barnhill RL, Lugassy C. Angiotropic malignant melanoma and extravascular migratory metastasis: description of 36 cases with emphasis on a new mechanism of tumour spread. Pathology. 2004; 36:485-490.
7. Barnhill RL, Fine JA, Roush GC, et al. Predicting five-year outcome for patients with cutaneous melanoma in a population-based study. Cancer. 1996;78:427-432.
8. Borgstein PJ, Meijer S, van Diest PJ. Are locoregional cutaneous metastases in melanoma predictable? Ann Surg Oncol. 1999;6: 315-321.
9. Clark WH Jr, From L, Bernardino EA, et al. The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res. 1969;29:705-727.
10. Gerami P, Shea C, Stone MS. Angiotropism in epidermotropic metastatic melanoma: another clue to the diagnosis. Am J Dermatopathol. 2006;28:429-433.
11. Heenan PJ. Local recurrence of melanoma. Pathology. 2004;36: 491-495.
12. Heenan PJ, Maise JC, Cook MG, et al. Persistent melanoma or local metastasis of melanoma. In: Le Boit PE, Burg G, Weedon D, et al, eds. World Health Organization Classification of Tumors Pathology and Genetics: Skin Tumors. Lyon: IARC Press; 2006:90-92.
13. Kashani-Sabet M, Sagebiel RW, Ferreira CM, et al. Vascular involvement in the prognosis of primary cutaneous melanoma. Arch Dermatol. 2001;137:1169-1173.
14. Kerr S, Going JJ. Angiocentric invasion by lentigo maligna melanoma. J Clin Pathol. 1994;47:183-184.
15. Le Boit PE, Burg G, Weedon D, et al, eds. World Health Organization Classification of Tumors. Pathology and Genetics: Skin Tumors. Lyon: IARC Press; 2006:50.
16. Lugassy C, Eyden BP, Christensen L, et al. Angio-tumoral complex in human malignant melanoma characterised by free laminin: ultrastructural and immunohistochemical observations. J Submicrosc Cytol Pathol. 1997;29:19-28.
17. Lugassy C, Dickersin GR, Christensen L, et al. Ultrastructural and immunohistochemical studies of the periendothelial matrix in human melanoma: evidence for an amorphous matrix containing laminin. J Cutan Pathol. 1999;26:78-83.
18. Lugassy C, Shahsafaei A, Bonitz P, et al. Tumor microvessels in melanoma express the beta-2 chain of laminin. Implications for melanoma metastasis. J Cutan Pathol. 1999;26:222-226.
19. Lugassy C, Kleinman HK, Engbring JA, et al. Pericyte-like location of GFP-tagged melanoma cells: ex vivo and in vivo studies of extravascular migratory metastasis. Am J Pathol. 2004;164: 1191-1198.
20. Lugassy C, Vernon SE, Warner JW, et al. Angiotropism of human prostate cancer cells: implications for extravascular migratory metastasis. BJU Int. 2005;95:1099-1103.
21. Lugassy C, Vernon SE, Busam K, et al. Angiotropism of human melanoma: studies involving in transit and other cutaneous metastases and the chicken chorioallantoic membrane: implications for extravascular melanoma invasion and metastasis. Am J Dermatopathol. 2006;28:187-193.
22. McGovern VJ, Cochran AJ, Van der Esch EP, et al. The classification of malignant melanoma, its histological reporting and registration: a revision of the 1972 Sydney classification. Pathology. 1986;18:12-21.
23. Moreno A, Espanol I, Romagosa V. Angiotropic malignant melanoma. Report of two cases. J Cutan Pathol. 1992;19:325-329.
24. Pawlik TM, Ross MI, Johnson MM, et al. Predictors and natural history of in-transit melanoma after sentinel lymphadenectomy. Ann Surg Oncol. 2005;12:587-596.
25. Saluja A, Money N, Zivony DI, et al. Angiotropic malignant melanoma: a rare pattern of local metastases. J Am Acad Dermatol. 2001;44:829-832.
26. Scolyer RA, Shaw HM, Thompson JF, et al. Interobserver reproducibility of histopathologic prognostic variables in primary cutaneous melanomas. Am J Surg Pathol. 2003;27: 1571-1576.
27. Shea CR, Kline MA, Lugo J, et al. Angiotropic metastatic malignant melanoma. Am J Dermatopathol. 1995;17:58-62.
28. Urist MM, Balch CM, Soong S, et al. The influence of surgical margins and prognostic factors predicting the risk of local recurrence in 3445 patients with primary cutaneous melanoma. Cancer. 1985;55:1398-1402.
29. van Poll D, Thompson JF, Colman MH, et al. A sentinel node biopsy does not increase the incidence of in-transit metastasis in patients with primary cutaneous melanoma. Ann Surg Oncol. 2005; 12:597-608.