Synthesis and antiulcer activity studies of 2-(1′-iminothioimido substituted)-1′-substituted phenylbenzoic acids

Indian Journal of Pharmaceutical Sciences

Volumn 70, Issue 3, 2008, Pages 381-383

  Subudhi, B ^a   Bhatta, D ^a   Panda, P ^a   Mishra, P ^a   Pradhan, D ^a  

^a UTKAL UNIVERSITY   (India)

Author keywords

Benzimidazole; Benzothiazole; Benzotriazole; Free acidity; Total acidity; Ulcer index

Indexed keywords

1 PHENYL 3 METHYL 5 PYRAZOLONE; 2 (1' IMINOTHIOIMIDO O HYDROXYBENZYL) 1' (2'' MERCAPTOBENZTHIAZOLYL)BENZOIC ACID; 2 (4 AMINOPHENYL)BENZIMIDAZOLE; 2 MERCAPTOBENZOTHIAZOLE; ANTIULCER AGENT; BENZENE DERIVATIVE; BENZOIC ACID DERIVATIVE; BENZOTRIAZOLE DERIVATIVE; FURFURAL; IMIDE; IMINE; OMEPRAZOLE; PHTHALIC ANHYDRIDE; PYRAZOLONE DERIVATIVE; SALICYLALDEHYDE; SCHIFF BASE; THIOUREA; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; MALE; NONHUMAN; QUANTUM YIELD; RAT; REACTION ANALYSIS; SCORING SYSTEM; STOMACH ULCER; STRUCTURE ACTIVITY RELATION; ULCER INDEX;

EID: 52149122353     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.43009     Document Type: Article

References (14)

1. Cunningham R, Dale B, Undy B, Gaunt N. Proton pump inhibitors as a risk factor for C. difficalies diarrhoea. J Hosp Infect 2003;54:243-5.
2. 12 levels in patients with Zollinger-Ellison syndrome. Am J Med 1998;104:422-30.
3. Connell MB, Modern DM, Murray AM. Effects of proton pump inhibitors on calcium carbonate absorption: A randomized crossover trial. Am J Med 2005;118:778-81.
4. Laheji RJ, Strukenboom MC, Hassing RJ, Dieleman J, Stricker BH. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. J Am Med Assoc 2004;292:1955-60.
5. Andreas HW, Klaus W. Gastric proton pump inhibitors. In: Manfred WE, editor. Burger's medicinal chemistry and drug discovery. Vol. II. 5th ed. New York: John Willey and Sons; 1996. p. 142-5.
6. + binding site of gastric proton pump enzyme. J Med Chem 1991;34:533-41.
7. +)-ATPase.1-Aryl pyrolo [3,2-c] quinolines: Effect of the 4-substituent. J Med Chem 1992;35:1845-52.
8. Yu KS, Bae KS, Shon JH, Cho JY, Yi SY, Chung JY, et al. Pharmacokinetic and pharmacodynamic evaluation of a novel proton pump inhibitor YH1885, in healing volunteers. J Clin Pharmacol 2004;44:73-82.
9. +)-ATPase. Substituted 2,4-diaminoquinazolines and thienopyramidines. J Med Chem 1995;38:2763-73.
10. Perlin DS. Ion pumps as targets for therapeutic intervention: Old and new paradigms. Electronic J Biotechnol 1998;1:55-64.
11. +)-ATPase. J Med Chem 1990;33:543-52.
12. Kulkarni SK. Hand book of experimental pharmacology. 3rd ed. Delhi: Vallabh Prakashan; 1999.
13. st ed. New Delhi: New Age International; 2004.
14. Furniss BS, Hannaford AJ, Smith PW, Tatchell AR, editors. Vogel.s text book of practical organic chemistry. Singapore: Pearson Education; 1988.