Papillary renal cell carcinoma with low-grade spindle cell foci: A mimic of mucinous tubular and spindle cell carcinoma

American Journal of Surgical Pathology

Volumn 32, Issue 9, 2008, Pages 1353-1359

  Argani, Pedram ^a,c   Netto, George J ^a   Parwani, Anil V ^b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Fluorescence in situ hybridization; Mucinous tubular and spindle cell carcinoma; Papillary renal cell carcinoma; Renal cell carcinoma

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYTOKERATIN 7;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER GRADING; CHROMOSOME 17; CHROMOSOME 3; CHROMOSOME 5; CHROMOSOME 7; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KIDNEY CARCINOMA; MALE; METASTASIS; MUCINOUS CARCINOMA; PAPILLARY CARCINOMA; SPINDLE CELL CARCINOMA; TRISOMY; CARCINOMA; COLLOID CARCINOMA; DIFFERENTIAL DIAGNOSIS; GENETICS; KIDNEY TUMOR; MIDDLE AGED; PATHOLOGY;

ADENOCARCINOMA, MUCINOUS; ADOLESCENT; ADULT; AGED; CARCINOMA; CARCINOMA, RENAL CELL; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 7; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; TRISOMY;

EID: 52149116020     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31816a1c34     Document Type: Article

References (27)

1. Amin MB, Corless CL, Renshaw AA, et al. Papillary (chromophil) renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 62 cases. Am J Surg Pathol. 1997;6:621-635.
2. Brandal P, Lie AK, Bassarova A, et al. Genomic aberrations in mucinous tubular and spindle cell renal cell carcinomas. Mod Pathol. 2006;19:186-194.
3. Brunelli M, Eble JN, Zhang S, et al. Metanephric adenoma lacks the gains of chromosomes 7 and 17 and loss of Y that are typical of papillary renal cell carcinoma and papillary adenoma. Mod Pathol. 2003;16:1060-1063.
4. Cossu-Rocca P, Eble JN, Delahunt B, et al. Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma. Mod Pathol. 2006;19:488-493.
5. Delahunt B, Eble JN. Papillary renal cell carcinoma: a Clinico-pathologic and Immunohistochemical Study of 105 tumors. Mod Pathol. 1997;10:537-544.
6. Delahunt B, Eble JN. Papillary renal cell carcinoma. In: Eble JN, Sauter G, Epstein J, et al, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of the Urinary System & Male Genital Organs. Lyon, France: IARC; 2003:27-29.
7. Eble JN. Mucinous tubular and spindle cell carcinoma and post-neuroblastoma carcinoma: newly recognized entities in the renal cell carcinoma family. Pathology. 2003;35:499-504.
8. Ferlicot S, Allory Y, Comperat E. Mucinous tubular and spindle cell carcinoma: a report of 15 cases and a review of the literature. Virchows Arch. 2005;447:978-983.
9. Fine SW, Argani P, DeMarzo AM, et al. Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney. Am J Surg Pathol. 2006;30:1554-1560.
10. Hes O, Hora M, Perez-Montiel DM, et al. Spindle and cuboidal renal cell carcinoma, a tumour having frequent association with nephrolithiasis: report of 11 cases including as case with hybrid conventional renal cell carcinoma/spindle and cuboidal renal cell carcinoma components. Histopathology. 2002;41:549-555.
11. Hughson MD, Dickman K, Bigler SA, et al. Clear-cell and papillary carcinoma of the kidney: an analysis of chromosome 3, 7, and 17 abnormalities by microsatellite amplification, cytogenetics, and fluorescence in situ hybridization. Cancer Genet Cytogenet. 1998; 106:93-104.
12. Kovacs G, Fuzesi L, Emanual A, et al. Cytogenetics of papillary renal cell tumors. Genes Chromosomes Cancer. 1991;3:249-255.
13. Lager DJ, Huston BJ, Timmerman TG, et al. Papillary renal tumors. Morphologic, cytochemical, and genotypic features. Cancer. 1995;76:669-673.
14. MacLennan GT, Farrow GM, Bostwick DG. Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. Urology. 1997;50:679-684.
15. Mancilla-Jimenez R, Stanley RJ, Blath RA. Papillary renal cell carcinoma. A Clinical, Radiologic, and Pathologic Study of 34 cases. Cancer. 1976;38:2469-2480.
16. Paner GP, Srigley JR, Radhakrishnan A, et al. Immunohistochem-ical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immuno-phenotypic overlap warrants diagnostic caution. Am J Surg Pathol. 2006;30:13-19.
17. Parwani AV, Husain AN, Epstein JI, et al. Low-grade myxoid renal epithelial neoplasms with distal nephron differentiation. Hum Pathol. 2001;32:506-512.
18. Rakozy C, Schmahl GE, Bogner S, et al. Low grade tubular-mucinous renal neoplasms: morphologic, immunohistochemical, and genetic features. Mod Pathol. 2002;15:1162-1171.
19. Renshaw AA, Corless CL. Papillary renal cell carcinoma. Histology and immunohistochemistry. Am J Surg Pathol. 1995;19:842-849.
20. Renshaw AA, Zhang H, Corless CL, et al. Solid variants of papillary (chromophil) renal cell carcinoma: clinicopathologic and genetic features. Am J Surg Pathol. 1997;21:1203-1209.
21. Salama ME, Worsham MJ, DePeralta-Venturina M. Malignant papillary renal tumors with extensive clear cell change: a molecular analysis by microsatellite analysis and fluorescence in situ hybridization. Arch Pathol Lab Med. 2003;127:1176-1181.
22. Shen SS, Ro JY, Tamboli P, et al. Mucinous tubular and spindle cell carcinoma of kidney is probably a variant of papillary renal cell carcinoma with spindle cell features. Ann Diagn Pathol. 2007;11: 13-21.
23. Srigley J. Mucinous tubular and spindle cell carcinoma. In: Eble JN, Sauter G, Epstein J, et al, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of the Urinary System & Male Genital Organs. Lyon, France: IARC; 2003:40.
24. Srigley JR, Eble JN, Grignon DJ, et al. Unusual renal cell carcinoma (RCC) with prominent spindle cell change possibly related to the loop of Henle. Mod Pathol. 1999;12:107A.
25. Srigley JR, Kapusta L, Reuter V, et al. Phenotypic, molecular, and ultrastructural studies of a novel low grade renal epithelial neoplasm possibly related to the loop of Henle. Mod Pathol. 2002;15:182A.
26. Val-Bernal JF, Gomez-Roman JJ, Vallina T, et al. Papillary (chromophil) renal cell carcinoma with mucinous secretion. Pathol Res Pract. 1999;195:11-17.
27. Weber A, Srigley JR, Moch H. Mucinous spindle cell carcinoma of the kidney. A molecular analysis. Pathologe. 2003;24:453-459.