Adaptations to short-term muscle unloading in young and aged men

Medicine and Science in Sports and Exercise

Volumn 40, Issue 5, 2008, Pages 856-863

  Deschenes, Michael R ^a,b   Holdren, Ashley N ^a,b   Mccoy, Raymond W ^a  

^a Department of Kinesiology ^*  (United States)

^b The College of William and Mary   (United States)

Author keywords

Cortisol; Disuse; Neuromuscular; Strength; Testosterone; Unweighting

Indexed keywords

ADAPTATION; ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CATABOLISM; CONTROLLED STUDY; ELECTROMYOGRAPHY; GROUPS BY AGE; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE CONTRACTION; MUSCLE EXERCISE; MUSCLE FUNCTION; MUSCLE ISOMETRIC CONTRACTION; NORMAL HUMAN; STATISTICAL SIGNIFICANCE; VELOCITY; AGING; ANTHROPOMETRY; BLOOD; ENDURANCE; IMMOBILIZATION; MUSCLE ATROPHY; PHYSIOLOGY; QUESTIONNAIRE; SKELETAL MUSCLE; TORQUE; WEIGHT BEARING;

HYDROCORTISONE; TESTOSTERONE;

ADAPTATION, PHYSIOLOGICAL; ADULT; AGED; AGING; ANALYSIS OF VARIANCE; ANTHROPOMETRY; ELECTROMYOGRAPHY; HUMANS; HYDROCORTISONE; IMMOBILIZATION; MALE; MUSCLE, SKELETAL; MUSCULAR ATROPHY; PHYSICAL ENDURANCE; QUESTIONNAIRES; TESTOSTERONE; TORQUE; WEIGHT-BEARING;

EID: 52149096750     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e318164f4b6     Document Type: Article

References (40)

1. Adams GR, Hather BM, Dudley GA. Effect of short-term unweighting on human muscle strength and size. Aviat Space Environ A Med. 1994;65:1116-21.
2. Aniansson A, Hedberg M, Henning GB, Grimby G. Muscle morphology, enzymatic activity, and muscle strength in elderly men: a follow-up study. Muscle Nerve. 1986;9:585-91.
3. Ansved T, Larsson L. Quantitative and qualitative morphological properties of the soleus motor nerve and the L5 ventral root in young and old rats. Relation to number of soleus muscle fibres. J Neurol Sci. 1990;96:269-82.
4. Auclair D, Garrel DR, Chaouki Zerouala A, Ferland LH. Activation of the ubiquitin pathway in rat skeletal muscle by catabolic doses of glucocorticoids. Am J Physiol. 1997;272: C1007-16.
5. Berg HE, Dudley GA, Haggmark T, Ohlsen H, Tesch PA. Effects of lower limb unloading on skeletal muscle mass and function in humans. J Appl Physiol. 1991;70:1882-5.
6. Berg HE, Dudley GA, Hather B, Tesch PA. Work capacity and metabolic and morphologic characteristics of the human quadriceps muscle in response to unloading, Clin Physiol. 1993;13: 337-47.
7. Berg HE, Tesch PA. Changes in muscle function in response to 10 days of lower limb unloading in humans. Acta Physiol Scand. 1996;157:63-70.
8. CENTRAL STATISTICS OFFICE. Social Trends. London (UK): Department of Health and Social Security, Government Statistical j Service; 1987. p. 17.
9. Cunnigham DA, Morrison D, Rice CL, Cooke C. Ageing and isokinetic plantar flexion. Eur J Appl Physiol Occup Physiol. 1987;56:24-9.
10. Deschenes MR, Giles JA, McCoy RW, Volek JS, Gomez AL, Kraemer WJ. Neural factors account for strength decrements observed after short-term muscle unloading. Am J Physiol. 2002;282:R578-83.
11. Di Minno G, Tufano A. Challenges in the prevention of venous thromboembolism in the elderly. J Tlvomb Haemost. 2004;2:1292-8.
12. Doherty TJ, Vandervoort AA, Brown WF. Effects of ageing on the motor unit: a brief review. Can J Appl Physiol. 1993;18:331-58.
13. Drafta D, Schindler AE, Stroe E, Neacsu E. Age-related changes of plasma steroids in normal adult males. J Steroid Biochem. 1982; 17:683-7.
14. Dudley GA, Duvoisin MR, Adams GR, Meyer RA, Belew AH, Buchanan P. Adaptations to unilateral lower limb suspension in humans. Aviat Space Environ Med. 1992;63:678-83.
15. Elmlinger MW, Dengler T, Weinstock C, Kuehnel W. Endocrine alterations in the aging male. Clin Chem Lab Med. 2003;41:934-41.
16. Frontera WR, Hughes VA, Fielding RA, Fiatarone MA, Evans WJ, Roubenoff R. Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol. 2000;88:1321-6.
17. Harries UJ, Bassey EJ. Torque-velocity relationships for the knee extensors in women in their 3rd and 7th decades. Enr J Appl Physiol Occup Physiol. 1990;60:187-90.
18. Hasselgren PO. Glucocorticoids and muscle metabolism. Curr Opin Clin Nutr Metab Care. 1999;2:201-5.
19. Hather BM, Adams GR, Tesch PA, Dudley GA. Skeletal muscle responses to lower limb suspension in humans. J Appl Physiol. 1992;72:1493-8.
20. Hedge GA, Colby HD, Goodman RL. Clinical Endocrine Physiology. Philadelphia (PA): Saunders; 1987. p. 136-7.
21. Kamen G, Caldwell GE. Physiology and interpretation of the electromyogram. J Clin Neurophysiol. 1996;13:366-84.
22. Kohl HW, Blair SN, Paffenbarger RS, Macera CA, Kronenfeld JJ. The aerobics center longitudinal study physical activity questionnaire. Med Sci Sports Exerc. 1997;29(6 Suppl.):S10-4.
23. Kraemer WJ. Endocrine responses to resistance exercise. Med Sci Sports Exerc. 1988;20(5 Suppl.):S152-7.
24. Kraemer WJ, Hakkinen K, Newton RU, et al. Effects of heavy-resistance training on hormonal response patterns in younger vs older men. J Appl Physiol. 1999;87:982-92.
25. Larsson L. Motor units: remodeling in aged animals. J Gerontol A Biol Sci Med Sci. 1995;50:91-5.
26. Larsson L, Grimby G, Karlsson J. Muscle strength and speed movement in relation to age and muscle morphology. J Appl Physiol. 1979;46:451-6.
27. Lavemia C, Lee DJ, Hernandez VH. The increasing financial burden of knee revision surgery in the United States. Clin Orthop Relat Res. 2006;446:221-6.
28. LeBIanc A, Gogia P, Schneider V, Krebs J, Evans H. Calf muscle area and strength after five weeks of horizontal bed rest Am J Sports Med. 1988; 16:624-9.
29. Lexell J. Human aging, muscle mass, and fiber type composition J Gerontol A Biol Sci Med Sci. 1995;50:11-6.
30. Lexell J, Taylor CC, Sjostrom M. What is the cause of ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci. 1988;84:275-94.
31. Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS Sarcopenia. J Lab Clin Med. 2001;137:231-43.
32. Morley JE, Kaiser FE, Perry HM 3rd, et al. Longitudinal changes in testosterone, Iuteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism. 1997;46:410-3.
33. NATIONAL CENTER FOR HEALTH STATISTICS. Older Americans Update, 2006. Hyattesville (MD): U.S. Department of Health and Human Services, Centers for Disease Control and Prevention; 2006. p. 124.
34. Pagnano MW, Clarke HD, Jacofsky DJ, Amendola A, Repicci JA. Surgical treatment of the middle-aged patient with arthritic knees. Instr Course Lect. 2005;54:251-9.
35. Rudman D, Kutner MH, Rogers CM, Lubin MF, Fleming GA, Bain RP. Impaired growth hormone secretion in the adult population: relation to age and adiposity. J Clin Invest. 1981;67: 1361-9.
36. Schulze K, Gallagher P, Trappe S. Resistance training preserves skeletal muscle function during unloading in humans. Med Sci Sports Exerc. 2002;34(2):303-13.
37. Seene T, Kaasik P, Pehme A, Alev K, Riso EM. The effect of glucocorticoids on the myosin heavy chain isoforms' turnover in skeletal muscle. J Steroid Biochem Mol Biol. 2003;86:201-6.
38. Spyropoulos AC, Merli G. Management of venous thromboemb-olism in the elderly. Drugs Aging. 2006;23:651-71.
39. Vaillancourt DE, Larsson L, Newell KM. Effects of aging on force variability, single motor unit discharge patterns, and the structure of 10, 20, and 40 Hz EMG activity. Neurobiol Aging. 2003;24:25-35.
40. Vermeulen A, Kaufman JM. Ageing of the hypothalamo-pituitary-testicular axis in men. Horm Res. 1995;43:25-8.