Physicochemical characteristics of molecules and their diffusion across human vaginal mucosa

European Journal of Inflammation

Volumn 6, Issue 2, 2008, Pages 65-71

  van Eyk, Armorel D ^a   van Der Bijl, P ^a   Moll, L M ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

Author keywords

Diffusion; Human vaginal mucosa; Permeability; Physicochemical characteristics

Indexed keywords

ARECOLINE; BRADYKININ; CIMETIDINE; CYCLOSPORIN A; DIHYDROALPRENOLOL; ESTRADIOL; LIQUID NITROGEN; OXYTOCIN; PENICILLIN G; TACROLIMUS; VASOPRESSIN; WATER;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG DESIGN; DRUG PENETRATION; FEMALE; FLOW KINETICS; FROZEN SECTION; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; LIPOPHILICITY; MAJOR CLINICAL STUDY; MOLECULAR WEIGHT; PARTICLE SIZE; PERMEABILITY; PH; PHYSICAL CHEMISTRY; STEADY STATE; TISSUE INJURY; VAGINA EPITHELIUM; VAGINA MUCOSA;

EID: 52149093243     PISSN: 1721727X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1721727X0800600203     Document Type: Article

References (26)

1. Prego C, García M, Torres D, Alonso MJ. Transmucosal macromolecular drug delivery. J Contr Rel 2005; 101:151-62.
2. Wani MS. Current status in buccal delivery systems. http://www.pharmainfo.net/reviews/current-status-in-buccal- delivery-systems. 2007; accessed 15 November 2007.
3. Lee K-J, Johnson N, Castelo J, Sinko PJ, Grass G, Holme K, Lee Y-H. Effect of experimental pH on the in vitro permeability in intact rabbit intestines and Caco-2 monolayer. Eur J Pharm Sci 2005; 25:193-200.
4. Boisset M, Botham P, Haegele KD, Lenfant B, Pachot JI. Absorption of angiotensen II antagonists in Ussing chambers, Caco-2, perfused jejunum loop and in vivo: Importance of drug ionisation in the in vitro prediction of in vivo absorption. Eur J Pharm Sci 2000; 10:215-24.
5. Karlsson J, Yngell A-L, Gråsjö J, Artursson P. Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux. Eur J Pharm Sci 1999; 9:47-56.
6. Wertz PW, Squier CA. Cellular and molecular basis of barrier function in oral epithelium. Crit Rev Therap Drug Carrier Syst 1991; 8(3):237-69.
7. Mahalingam R, Ravivarapu H, Redkar S, Li X, Jasti BR. Transbuccal delivery of 5-aza-2′ - deoxycytidine: effects of drug concentration, buffer solution, and bile salts on permeation. AAPS Pharm Sci Tech 2007; 8(3):Article 55. DOI: 10.1208/pt0803055.
8. Salama NN, Eddington ND, Fasano A. Tight junction modulation and its relationship to drug delivery. Ad Drug Del Rev 2006; 58:18-28.
9. Justin-Temu M, Damian F, Kinget R, Van den Mooter G. Intravaginal gels as drug delivery systems. J Women's Health 2004; 13(7):834-44.
10. Mashru R, Sutariya V, Sankalia M, Sankalia J. Transbuccal delivery of lamotrigine across porcine buccal mucosa: in vitro determination of routes of buccal transport. J Pharm Pharm Sci 2005; 8(1):54-62.
11. Aurora J, Pathak V. The fate of drugs and drug development: an overview. Drug Deliv Tech 2004; 4(3). Online version: http://www.drugdeliverytech.com.
12. Nielsen HM, Rassing MR. Nicotine permeability across the buccal TR146 cell culture model and porcine buccal mucosa in vitro: effect of pH and concentration. Eur J Pharm Sci 2002; 16(3):151-57.
13. Senel S, Kremer M, Nagy K, Squier C. Delivery of bioactive peptides and proteins across oral (buccal) mucosa. Curr Pharm Biotechnol 2001; 2(2):175-86.
14. Loftsson T, Konráosdóttir F, Másson M. Influence of aqueous diffusion layer on passive drug diffusion from aqueous cyclodextrin solutions through biological membranes. Pharmazie 2006; 61(2):83-9.
15. Loftsson T, Brewster ME, Másson M. Role of cyclodextrins in improving oral drug delivery. Am J Drug Deliv 2004; 2(4):261-75.
16. Nicolazzo JA, Reed BL, Finnin BC. The effect of various in vitro conditions on the permeability characteristics of the buccal mucosa. J Pharm Sci 2003; 92(12):2399-410.
17. Van der Bijl P, Van Eyk AD, Thompson IOC. Permeation of 17β-estradiol through human vaginal and buccal mucosa. Oral Surg Oral Med Oral Path Oral Radiol Endo 1998; 85:393-8.
18. Moll LM, Van Eyk AD, Van der Bijl P. In vitro permeability of intact and de-epithelialised human vaginal mucosa to tacrolimus and cyclosporin A. Eur J Inflam 2007; 5(1):7-14.
19. Basson E, Van der Bijl P, Van Eyk AD. Transvaginal diffusion of synthetic peptides. Eur J Inflam 2007; 5(1):15-20.
20. Van Eyk AD, Van der Bijl P. Comparative permeability of various chemical markers through human vaginal and buccal mucosa as well as porcine buccal and mouth floor mucosa. Arch Oral Biol 2004; 49(5):387-92.
21. Motulsky H. Intuitive Biostatistics. In: Graphpad Software, Oxford University Press, New York, 1995.
22. Rojanasakul Y, Wang L-Y, Bhat M, Glover DD, Malanga CJ, Ma JKH. The transport barrier of epithelia: a comparative study on membrane permeability and charge selectivity in the rabbit. Pharm Res 1992; 9(8):1029-34.
23. Krogsgaard-Larsen P, Frydenvang K. Acetylcholine and histamine receptors and receptor-ligands: medical chemistry and therapeutic aspects. In Textbook of drug design. P Krogsgaard-Larsen, T. Liljefors and U. Madsen, ed. CRC Press, United States, 2002; p282.
24. Nielsen HM, Rassing MR. TR146 cells grown on filters as a model of human buccal epithelium: IV. Permeability of water, mannitol, testosterone and β-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa. Int J Pharm 2000; 194:155-67.
25. Mahato RI, Narang AS, Thoma L, Miller DD. Emerging trends in oral delivery of peptide and protein drugs. Crit Rev Therap Drug Carrier Syst 2003; 20153-214.
26. Akhlaghi F, Trull AK. Distribution of cyclosporine in organ transplant recipients. Clin Pharmacokinet 2002; 41(9):615-37.