Does the 3-gene diagnostic assay accurately distinguish benign from malignant thyroid neoplasms?

Cancer

Volumn 113, Issue 5, 2008, Pages 930-935

  Shibru, Daniel ^a   Hwang, Jimmy ^b   Khanafshar, Elham ^c   Duh, Quan Yang ^a   Clark, Orlo H ^a,b   Kebebew, Electron ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

3 gene assay; Diagnosis; Fine needle aspiration biopsy; Polymerase chain reaction; Thyroid cancer

Indexed keywords

MESSENGER RNA; CCND2 PROTEIN, HUMAN; CYCLINE; CYTOKINE; GROWTH DIFFERENTIATION FACTOR 15; PROPROTEIN CONVERTASE 2;

AREA UNDER THE CURVE; ARTICLE; ASPIRATION BIOPSY; BENIGN TUMOR; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FROZEN SECTION; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; HUMAN TISSUE; MALIGNANT NEOPLASTIC DISEASE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID GLAND; THYROID TUMOR; TISSUE SECTION; DIAGNOSTIC PROCEDURE; EVALUATION; GENETICS; NEEDLE BIOPSY; PATHOLOGY; POLYMERASE CHAIN REACTION;

BIOPSY, FINE-NEEDLE; CYCLINS; CYTOKINES; GENE EXPRESSION; HUMANS; MOLECULAR DIAGNOSTIC TECHNIQUES; POLYMERASE CHAIN REACTION; PROPROTEIN CONVERTASE 2; THYROID NEOPLASMS;

EID: 52049120887     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.23703     Document Type: Article

References (19)

1. Hegedus L. Clinical practice. The thyroid nodule. N Engl J Med. 2004;351:1764-1771.
2. Baloch ZW, LiVolsi VA. The quest for a magic tumor marker: continuing saga in the diagnosis of the follicular lesions of thyroid. Am J Clin Pathol. 2002;118:165-166.
3. Barden CB, Shister KW, Zhu B, et al. Classification of follicular thyroid tumors by molecular signature: results of gene profiling. Clin Cancer Res. 2003;9:1792-1800.
4. Gasbarri A, Martegani MP, Del Prete F, Lucante T, Natali PG, Bartolazzi A. Galectin-3 and CD44v6 isoforms in the preoperative evaluation of thyroid nodules. J Clin Oncol. 1999;17:3494-3502.
5. Kebebew E, Peng M, Reiff E, McMillan A. Diagnostic and extent of disease multigene assay for malignant thyroid neoplasms. Cancer. 2006;106:2592-2597.
6. Maruta J, Hashimoto H, Yamashita H, Noguchi S. Immunostaining of galectin-3 and CD44v6 using fine-needle aspiration for distinguishing follicular carcinoma from adenoma. Diagn Cytopathol. 2004;31:392-396.
7. Mazzanti C, Zeiger MA, Costouros NG, et al. Using gene expression profiling to differentiate benign versus malignant thyroid tumors. Cancer Res. 2004;64:2898-2903.
8. Yashima K, Vuitch F, Gazdar AF, Fahey TJ III. Telomerase activity in benign and malignant thyroid diseases. Surgery. 1997;122:1141-1145; discussion 1145-1146.
9. Weber F, Shen L, Aldred MA, et al. Genetic classification of benign and malignant thyroid follicular neoplasia based on a 3-gene combination. J Clin Endocrinol Metab. 2005;90: 2512-2521.
10. Kebebew E, Peng M, Treseler PA, et al. Id1 gene expression is up-regulated in hyperplastic and neoplastic thyroid tissue and regulates growth and differentiation in thyroid cancer cells. J Clin Endocrinol Metab. 2004;89:6105-6111.
11. Ginzinger DG. Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream. Exp Hematol. 2002;30:503-512.
12. Puskas LG, Juhasz F, Zarva A, Hackler L Jr, Farid NR. Gene profiling identifies genes specific for well-differentiated epithelial thyroid tumors. Cell Mol Biol. 2005;51:177-186.
13. Talantov D, Mazumder A, Yu JX, et al. Novel genes associated with malignant melanoma but not benign melanocytic lesions. Clin Cancer Res. 2005;11:7234-7242.
14. Welsh JB, Sapinoso LM, Kern SG, et al. Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci USA. 2003;100:3410-3415.
15. Takano Y, Kato Y, Masuda M, Ohshima Y, Okayasu I. Cyclin D2, but not cyclin D1, overexpression closely correlates with gastric cancer progression and prognosis. J Pathol. 1999;189:194-200.
16. Jeon GA, Lee JS, Patel V, et al. Global gene expression profiles of human head and neck squamous carcinoma cell lines. Int J Cancer. 2004;112:249-258.
17. Ohlsson L, Hammarstrom ML, Israelsson A, et al. Biomarker selection for detection of occult tumour cells in lymph nodes of colorectal cancer patients using real-time quantitative RT-PCR. Br J Cancer. 2006;95:218-225.
18. Schroder CP, Ruiters MH, de Jong S, et al. Detection of micrometastatic breast cancer by means of real time quantitative RT-PCR and immunostaining in perioperative blood samples and sentinel nodes. Int J Cancer. 2003;106:611-618.
19. Finley DJ, Zhu B, Barden CB, Fahey TJ III. Discrimination of benign and malignant thyroid nodules by molecular profiling. Ann Surg. 2004;240:425-436; discussion 436-437.