The role of the endothelium in systemic small vessel vasculitis

Clinical and Experimental Rheumatology

Volumn 26, Issue 3 SUPPL. 49, 2008, Pages

  Little, Mark A ^a   Savage, Caroline O S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Adenosine; ANCA; Endothelium; Protease; Vasculitis; Wegener's granulomatosis

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA 1 ANTITRYPSIN; BIOLOGICAL MARKER; CELL ADHESION MOLECULE; DYFLOS; ENDOTHELIAL CELL ANTIBODY; LEUKOCYTE ELASTASE; LIPOXIN A; MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; SERINE PROTEINASE; VASCULAR CELL ADHESION MOLECULE 1; VON WILLEBRAND FACTOR;

ANCA ASSOCIATED VASCULITIS; CELL FUNCTION; CELL HETEROGENEITY; DISEASE SEVERITY; ENDOTHELIUM; ENDOTHELIUM INJURY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; INFLAMMATION; LEUKOCYTE ACTIVATION; NEUTROPHIL CHEMOTAXIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SMALL VESSEL VASCULITIS; WEGENER GRANULOMATOSIS;

ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; AUTOANTIBODIES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; NEUTROPHIL ACTIVATION; PEROXIDASE; VASCULITIS;

EID: 52049120388     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. KAHN RL: Tissue immunity; its possible relationship to midline facial granulomatous ulceration. Med Bull (Ann Arbor) 1954; 20: 209-18.
2. DE LIND VAN WIJNGAARDEN RA, VAN RIJN L, HAGEN EC et al.: Hypotheses on the etiology of antineutrophil cytoplasmic autoantibody associated vasculitis: The cause is hidden, but the result is known. Clin J Am Soc Nephrol 2008; 3: 237-52.
3. DONALD KJ, EDWARDS RL, MCEVOY JD: An ultrastructural study of the pathogenesis of tissue injury in limited Wegener's granulomatosis. Pathology 1976; 8: 161-9.
4. EWERT BH, JENNETTE JC, FALK RJ: Antimyeloperoxidase antibodies stimulate neutrophils to damage human endothelial cells. Kidney Int 1992; 41: 375-83.
5. SAVAGE CO, POTTINGER BE, GASKIN G, PUSEY CD, PEARSON JD: Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells. Am J Pathol 1992; 141: 335-42.
6. KEOGAN MT, RIFKIN I, RONDA N, LOCKWOOD CM, BROWN DL: Anti-neutrophil cytoplasm antibodies (ANCA) increase neutrophil adhesion to cultured human endothelium. Adv Exp Med Biol 1993; 336: 115-9.
7. MAYET WJ, MEYER ZUM BUSCHENFELDE KH: Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells. Clin Exp Immunol 1993; 94: 440-6.
8. EWERT BH, BECKER ME, JENNETTE JC, FALK RJ: Antimyeloperoxidase antibodies induce neutrophil adherence to cultured human endothelial cells. Ren Fail 1995; 17: 125-33.
9. LU X, GARFIELD A, RAINGER GE, SAVAGE CO, NASH GB: Mediation of endothelial cell damage by serine proteases, but not superoxide, released from antineutrophil cytoplasmic antibody-stimulated neutrophils. Arthritis Rheum 2006; 54: 1619-28.
10. NIENHUIS HL, DE LEEUW K, SMIT AJ et al.: Enhanced endothelium-dependent microvascular responses in patients with Wegener's granulomatosis. J Rheumatol 2007; 34: 1875-81.
11. SAVAGE CO, GASKIN G, PUSEY CD, PEARSON JD: Anti-neutrophil cytoplasm antibodies can recognize vascular endothelial cell-bound anti-neutrophil cytoplasm antibody-associated autoantigens. Exp Nephrol 1993; 1: 190-5.
12. SAVAGE CO, GASKIN G, PUSEY CD, PEARSON JD: Myeloperoxidase binds to vascular endothelial cells, is recognized by ANCA and can enhance complement dependent cytotoxicity. Adv Exp Med Biol 1993; 336: 121-3.
13. RADFORD DJ, SAVAGE CO, NASH GB: Treatment of rolling neutrophils with antineutrophil cytoplasmic antibodies causes conversion to firm integrin-mediated adhesion. Arthritis Rheum 2000; 43: 1337-45.
14. RADFORD DJ, LUU NT, HEWINS P, NASH GB, SAVAGE CO: Antineutrophil cytoplasmic antibodies stabilize adhesion and promote migration of flowing neutrophils on endothelial cells. Arthritis Rheum 2001; 44: 2851-61.
15. LITTLE MA, SMYTH CL, YADAV R et al.: Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo. Blood 2005; 106: 2050-8.
16. NOLAN SL, KALIA N, NASH GB, KAMEL D, HEERINGA P, SAVAGE COS: Mechanisms of ANCA-mediated leukocyte-endothelial cell interactions in vivo. J Am Soc Nephrol 2008: 19; 973-84.
17. HOLMEN C, ELSHEIKH E, STENVINKEL P et al.: Circulating inflammatory endothelial cells contribute to endothelial progenitor cell dysfunction in patients with vasculitis and kidney involvement. J Am Soc Nephrol 2005; 16: 3110-20.
18. WOYWODT A, STREIBER F, DE GROOT K, REGELSBERGER H, HALLER H, HAUBITZ M: Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis. Lancet 2003; 361: 206-10.
19. WOYWODT A, GOLDBERG C, KIRSCH T et al.: Circulating endothelial cells in relapse and limited granulomatous disease due to ANCA associated vasculitis. Ann Rheum Dis 2006; 65: 164-8.
20. DE GROOT K, GOLDBERG C, BAHLMANN FH et al.: Vascular endothelial damage and repair in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 2007; 56: 3847-53.
21. BEARER E, ORCI L: EndotheliaA fenestral diaphragms: a quick-freeze, deep-etch study. J Cell Biol 1985; 100: 418-28.
22. RASTALDI MP, FERRARIO F, TUNESI S, YANG L, D'AMICO G: Intraglomerular and interstitial leukocyte infiltration, adhesion molecules, and interleukin-1 alpha expression in 15 cases of antineutrophil cytoplasmic autoantibody-associated renal vasculitis. Am J Kidney Dis 1996; 27: 48-57.
23. SEBASTIAN JK, MAHR AD, AHMED SS et al.: Antiendothelial cell antibodies in patients with Wegener's granulomatosis: Prevalence and correlation with disease activity and manifestations. J Rheumatol 2007; 34: 1027-31.
24. VARAGUNAM M, NWOSU AC, ADU D et al.: Little evidence for anti-endothelial-cell antibodies in microscopic polyarteritis and Wegener's granulomatosis. Adv Exp Med Biol 1993; 336: 419-22.
25. SAVAGE CO, POTTINGER BE, GASKIN G, LOCKWOOD CM, PUSEY CD, PEARSON JD: Vascular damage in Wegener's granulomatosis and microscopic polyarteritis: Presence of anti-endothelial cell antibodies and their relation to anti-neutrophil cytoplasm antibodies. Clin Exp Immunol 1991; 85: 14-9.
26. CHAN TM, FRAMPTON G, JAYNE DR, PERRY GJ, LOCKWOOD CM, CAMERON JS: Clinical significance of anti-endothelial cell antibodies in systemic vasculitis: A longitudinal study comparing anti-endothelial cell antibodies and anti-neutrophil cytoplasm antibodies. Am J Kidney Dis 1993; 22: 387-92.
27. SMITH JD, LAWSON C, YACOUB MH, ROSE ML: Activation of NF-kappa B in human endothelial cells induced by monoclonal and allospecific HLA antibodies. Int Immunol 2000; 12: 563-71.
28. VAN PAASSEN P, COHEN TERVAERT JW, HEERINGA P: Mechanisms of vasculitis: How pauci-immune is ANCA-associated renal vasculitis? Nephron Exp Nephrol 2007; 105: E10-6.
29. JAMIN C, DUGUE C, ALARD JE et al.: Induction of endothelial cell apoptosis by the binding of anti-endothelial cell antibodies to Hsp60 in vasculitis-associated systemic autoimmune diseases. Arthritis Rheum 2005; 52: 4028-38.
30. BALLIEUX BE, HIEMSTRA PS, KLAR-MOHAMAD N et al.: Detachment and cytolysis of human endothelial cells by proteinase 3. Eur J Immunol 1994; 24: 3211-5.
31. YANG JJ, KETTRITZ R, FALK RJ, JENNETTE JC, GAIDO ML: Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase. Am J Pathol 1996; 149: 1617-26.
32. PRESTON GA, ZARELLA CS, PENDERGRAFT WF 3RD et al.: Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways. J Am Soc Nephrol 2002; 13: 2840-9.
33. ESNAULT VL, TESTA A, AUDRAIN M et al.: Alpha 1-antitrypsin genetic polymorphism in ANCA-positive systemic vasculitis. Kidney Int 1993; 43: 1329-32.
34. AUDRAIN MA, SESBOUE R, BARANGER TA et al.: Analysis of anti-neutrophil cytoplasmic antibodies (ANCA): Frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects. Nephrol Dial Transplant 2001; 16: 39-44.
35. GRIFFITH ME, LOVEGROVE JU, GASKIN G, WHITEHOUSE DB, PUSEY CD: C-antineutrophil cytoplasmic antibody positivity in vasculitis patients is associated with the Z allele of alpha-1-antitrypsin, and P-antineutrophil cytoplasmic antibody positivity with the S allele. Nephrol Dial Transplant 1996; 11: 438-43.
36. XIAO H, SCHREIBER A, HEERINGA P, FALK RJ, JENNETTE JC: Alternative Complement Pathway in the Pathogenesis of Disease Mediated by Anti-Neutrophil Cytoplasmic Autoantibodies. Am J Pathol 2007; 170: 52-64.
37. SAVAGE CO: Endothelium and regulatory cell interactions. Clin Exp Rheumatol 2007; 25 (Suppl. 44): S46-8.
38. KRUPNICK AS, GELMAN AE, BARCHET W et al.: Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol 2005; 175: 6265-70.
39. ZERNECKE A, BIDZHEKOV K, OZUYAMAN B et al.: CD73/ecto-5′-nucleotidase protects against vascular inflammation and neointima formation. Circulation 2006; 113: 2120-7.
40. GOH J, BAIRD AW, O'KEANE C et al.: Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo. J Immunol 2001; 167: 2772-80.