Brain-derived neurotrophic factor enhances histamine-induced airway responses and changes levels of exhaled nitric oxide in guinea pigs in vivo

European Journal of Pharmacology

Volumn 595, Issue 1-3, 2008, Pages 78-83

  Bennedich Kahn, Lydia ^a   Gustafsson, Lars E ^a   Olgart Höglund, Caroline ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Airway; Asthma; Brain derived neurotrophic factor; Bronchial hyperresponsiveness; Histamine; L NAME (N L nitro L arginine methyl ester); Lung compliance; Neurotrophin; Nitric oxide; Pulmonary resistance

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; HISTAMINE; NITRIC OXIDE;

AERATION; AIRWAY DYNAMICS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; EXHALATION; GUINEA PIG; IN VIVO STUDY; LUNG COMPLIANCE; LUNG INJURY; LUNG PRESSURE; LUNG RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION;

ADMINISTRATION, INHALATION; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; BRONCHIAL HYPERREACTIVITY; BRONCHOCONSTRICTION; BRONCHOCONSTRICTOR AGENTS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EXHALATION; GUINEA PIGS; HISTAMINE; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; LUNG; LUNG COMPLIANCE; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PRESSURE; TIME FACTORS; VASCULAR RESISTANCE;

EID: 52049114879     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.07.041     Document Type: Article

References (30)

1. Amdur M.O., and Mead J. Mechanics of respiration in unanesthetized guinea pigs. Am. J. Physiol. 192 (1958) 364-368
2. Belvisi M.G., Stretton C.D., Yacoub M., and Barnes P.J. Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. Eur. J. Pharmacol. 210 (1992) 221-222
3. Bennedich Kahn L., Gustafsson L.E., and Olgart Höglund C. Nerve growth factor enhances neurokinin A-induced airway responses and exhaled nitric oxide via a histamine-dependent mechanism. Pulm. Pharmacol. Ther. 21 (2008) 522-532
4. Boulet L.P., Chakir J., Dube J., Laprise C., Boutet M., and Laviolette M. Airway inflammation and structural changes in airway hyper-responsiveness and asthma: an overview. Can. Respir. J. 5 (1998) 16-21
5. Braun A., Lommatzsch M., Mannsfeldt A., Neuhaus-Steinmetz U., Fischer A., Schnoy N., Lewin G.R., and Renz H. Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation. Am. J. Respir. Cell Mol. Biol. 21 (1999) 537-546
6. Braun A., Lommatzsch M., Neuhaus-Steinmetz U., Quarcoo D., Glaab T., McGregor G.P., Fischer A., and Renz H. Brain-derived neurotrophic factor (BDNF) contributes to neuronal dysfunction in a model of allergic airway inflammation. Br. J. Pharmacol. 141 (2004) 431-440
7. Dagnell C., Kemi C., Klominek J., Eriksson P., Sköld C.M., Eklund A., Grunewald J., and Olgart Höglund C. Effects of neurotrophins on human bronchial smooth muscle cell migration and matrix metalloproteinase-9 secretion. Transl. Res. 150 (2007) 303-310
8. Denis D., Fayon M.J., Berger P., Molimard M., De Lara M.T., Roux E., and Marthan R. Prolonged moderate hyperoxia induces hyperresponsiveness and airway inflammation in newborn rats. Pediatr. Res. 50 (2001) 515-519
9. de Vries A., Dessing M.C., Engels F., Henricks P.A., and Nijkamp F.P. Nerve growth factor induces a neurokinin-1 receptor-mediated airway hyperresponsiveness in guinea pigs. Am. J. Respir. Crit. Care Med. 159 (1999) 1541-1544
10. Estevez A.G., Spear N., Manuel S.M., Radi R., Henderson C.E., Barbeito L., and Beckman J.S. Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. J. Neurosci. 18 (1998) 923-931
11. Friberg S.G., Olgart Höglund C., and Gustafsson L.E. Nerve growth factor increases airway responses and decreases levels of exhaled nitric oxide during histamine challenge in an in vivo guinea-pig model. Acta Physiol. Scand. 173 (2001) 239-245
12. Friberg S.G., Kahn L.B., Agvald P., and Gustafsson L.E. Comparison between effects of intravenous and nebulized histamine in guinea pigs: correlation between changes in respiratory mechanics and exhaled nitric oxide. Eur. J. Pharmacol. 547 (2006) 143-151
13. Hahn C., Islamian A.P., Renz H., and Nockher W.A. Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation. J. Allergy Clin. Immunol. 117 (2006) 787-794
14. Hershenson M.B., Aghili S., Punjabi N., Hernandez C., Ray D.W., Garland A., Glagov S., and Solway J. Hyperoxia-induced airway hyperresponsiveness and remodeling in immature rats. Am. J. Physiol. 262 (1992) L263-269
15. Ishida K., Pare P.D., Thomson R.J., and Schellenberg R.R. Increased in vitro responses of tracheal smooth muscle from hyperresponsive guinea pigs. J. Appl. Physiol. 68 (1990) 1316-1320
16. Kemi C., Grunewald J., Eklund A., and Höglund C.O. Differential regulation of neurotrophin expression in human bronchial smooth muscle cells. Respir. Res. 7 (2006) 18
17. Lewin G.R., and Barde Y.A. Physiology of the neurotrophins. Annu. Rev. Neurosci. 19 (1996) 289-317
18. Lommatzsch M., Schloetcke K., Klotz J., Schuhbaeck K., Zingler D., Zingler C., Schulte-Herbruggen O., Gill H., Schuff-Werner P., and Virchow J.C. Brain-derived neurotrophic factor in platelets and airflow limitation in asthma. Am. J. Respir. Crit. Care Med. 171 (2005) 115-120
19. Lumb A.B. Nunn's Applied Respiratory Physiology. Fifth ed. (2003), Butterworh-Heinemann Ltd, Edinburgh
20. Naline E., Höglund C.O., Vincent F., Emonds-Alt X., Lagente V., Advenier C., and Frossard N. Role of tachykinin NK3 receptors in the release and effects of nerve growth factor in human isolated bronchi. Eur. J. Pharmacol. 560 (2007) 206-211
21. Nassenstein C., Braun A., Erpenbeck V.J., Lommatzsch M., Schmidt S., Krug N., Luttmann W., Renz H., and Virchow Jr. J.C. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. J. Exp. Med. 198 (2003) 455-467
22. Noga O., Hanf G., Schaper C., O'Connor A., and Kunkel G. The influence of inhalative corticosteroids on circulating nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in allergic asthmatics. Clin. Exp. Allergy 31 (2001) 1906-1912
23. Persson M.G., and Gustafsson L.E. Allergen-induced airway obstruction in guinea-pigs is associated with changes in nitric oxide levels in exhaled air. Acta Physiol. Scand. 149 (1993) 461-466
24. Persson M.G., Friberg S.G., Hedqvist P., and Gustafsson L.E. Endogenous nitric oxide counteracts antigen-induced bronchoconstriction. Eur. J. Pharmacol. 249 (1993) R7-8
25. Persson M.G., Friberg S.G., Gustafsson L.E., and Hedqvist P. The promotion of patent airways and inhibition of antigen-induced bronchial obstruction by endogenous nitric oxide. Br. J. Pharmacol. 116 (1995) 2957-2962
26. Prakash Y.S., Iyanoye A., Ay B., Mantilla C.B., and Pabelick C.M. Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle. Am. J. Physiol., Lung Cell. Mol. Physiol. 291 (2006) L447-L456
27. Ricci A., Felici L., Mariotta S., Mannino F., Schmid G., Terzano C., Cardillo G., Amenta F., and Bronzetti E. Neurotrophin and neurotrophin receptor protein expression in the human lung. Am. J. Respir. Cell Mol. Biol. 30 (2004) 12-19
28. Ricciardolo F.L., Nijkamp F.P., and Folkerts G. Nitric oxide synthase (NOS) as therapeutic target for asthma and chronic obstructive pulmonary disease. Curr. Drug Targets 7 (2006) 721-735
29. Virchow J.C., Julius P., Lommatzsch M., Luttmann W., Renz H., and Braun A. Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation. Am. J. Respir. Crit. Care Med. 158 (1998) 2002-2005
30. Yao Q., Haxhiu M.A., Zaidi S.I., Liu S., Jafri A., and Martin R.J. Hyperoxia enhances brain-derived neurotrophic factor and tyrosine kinase B receptor expression in peribronchial smooth muscle of neonatal rats. Am. J. Physiol., Lung Cell. Mol. Physiol. 289 (2005) L307-314