Does paracetamol cause asthma in children? Time to remove the guesswork

The Lancet

Volumn 372, Issue 9643, 2008, Pages 1011-1012

  Barr, R Graham ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIPYRETIC AGENT; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL;

ARTICLE; ASTHMA; BRONCHODILATATION; CAUSAL ATTRIBUTION; CLINICAL TRIAL; DRUG EFFECT; DRUG USE; ECZEMA; FEVER; HUMAN; PREVALENCE; PRIORITY JOURNAL; RHINOCONJUNCTIVITIS; RISK FACTOR; WHEEZING;

EID: 52049097066     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(08)61417-8     Document Type: Note

References (14)

1. Morse N.M. Ueber eine neue Darstellungsmethode der Acetylamidophenole. Berichte deutsch chemischen Gesellschaft 11 (1878) 232-233
2. Hawton K., Simkin S., Deeks J., et al. UK legislation on analgesic packs: before and after study of long term effect on poisonings. BMJ 329 (2004) 1076
3. Beasley R., Clayton T., Crane J., et al., for the ISAAC Phase Three Study Group. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme. Lancet 372 (2008) 1039-1049
4. Jenkins C., Costello J., and Hodge L. Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice. BMJ 328 (2004) 434
5. Park J.S., Chang H.S., Park C.S., et al. Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. Pharmacogenet Genomics 15 (2005) 483-492
6. Kim S.H., Choi J.H., Park H.S., et al. Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. Clin Exp Allergy 35 (2005) 585-590
7. Jinnai N., Sakagami T., Sekigawa T., et al. Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. Hum Mol Genet 13 (2004) 3203-3217
8. Kordansky D., Adkinson Jr. N.F., Norman P.S., and Rosenthal R.R. Asthma improved by nonsteroidal anti-inflammatory drugs. Ann Intern Med 88 (1978) 508-511
9. Barr R.G., Wentowski C.C., Curhan G.C., et al. Prospective study of acetaminophen use and risk of newly diagnosed asthma among women. Am J Respir Crit Care Med 169 (2004) 836-841
10. Varner A.E., Busse W.W., and Lemanske R.F.J. Hypothesis: decreasing use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma. Ann Allergy Asthma Immunol 81 (1998) 347-351
11. Barr R.G., Kurth T., Stampfer M.J., Buring J.E., Hennekens C.H., and Gaziano J.M. Low dose aspirin and decreased adult-onset asthma: randomized comparisons from the Physicians' Health Study. Am J Respir Crit Care Med 175 (2007) 120-125
12. Kurth T., Barr R.G., Gaziano J.M., and Buring J.E. Randomized aspirin assignment and risk of adult-onset asthma in the Women's Health Study. Thorax 63 (2008) 514-518
13. Lesko S.M., and Mitchell A.A. The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics 104 (1999) e39
14. Lesko S.M., Louik C., Vezina R.M., and Mitchell A.A. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 109 (2002) e20