Construction of tissue-engineered cartilage with BMP7 gene-transfected chondrocytes

Journal of International Medical Research

Volumn 36, Issue 4, 2008, Pages 837-847

  Qu, F J ^a   Liu, Y ^a   Zhu, D L ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Bone morphogenetic protein 7 (BMP7); Chondrocyte; Gene; Tissue engineering

Indexed keywords

COLLAGEN TYPE 2; GLYCOSAMINOGLYCAN; OSTEOGENIC PROTEIN 1; BONE MORPHOGENETIC PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CARTILAGE CELL; CARTILAGE TRANSPLANTATION; CELL BASED GENE THERAPY; CELL CULTURE; CHONDROPATHY; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; GOLGI COMPLEX; IN VITRO STUDY; MITOCHONDRION; MORPHOMETRICS; PROTEIN EXPRESSION; ROUGH ENDOPLASMIC RETICULUM; TISSUE ENGINEERING; TISSUE REPAIR; ADULT; ANIMAL; CARTILAGE; CYTOLOGY; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY;

ADULT; ANIMALS; BONE MORPHOGENETIC PROTEINS; CARTILAGE; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; GLYCOSAMINOGLYCANS; HUMANS; TISSUE ENGINEERING; TRANSFORMING GROWTH FACTOR BETA;

EID: 52049087821     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000803600427     Document Type: Article

References (12)

1. Hunziker EB; Biological repair of articular cartilage. Defect models in experimental animals and matrix requirements. Clin Orthop Relat Res 1999; 367(suppl): S135-S146.
2. Pavesio A, Abatangelo G, Borrione A, et al: Hyaluronan-based scaffolds (Hyalograft® C) in the treatment of knee cartilage defects: preliminary clinical findings: In: Tissue Engineering of Cartilage and Bone (Bock G, Goode J, eds). Chichester: John Wiley, 2003; pp 203-217.
3. Häselmann HJ, Fernandes RJ, Mok SS, et al: Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate bead. J Cell Sci 1994; 107: 17-27.
4. Wakitani S, Imoto K, Kimura T, et al: Hepatocyte growth factor facilitates cartilage repair. Full thickness articular cartilage defect studied in rabbit knees. Acta Orthop Scand 1997; 68: 474-480.
5. Hunziker EB, Rosenberg R: Induction of repair in partial thickness articular cartilage lesions by timed release of TGF-β. Trans Orthop Res Soc 1994; 19: 236-241.
6. Lindenhayn K, Parka C, Spitzer R, et al: Retention of hyaluronic acid in alginate beads: aspects for in vitro cartilage engineering. J Biomed Mater Res 1999; 44: 149-155.
7. Giannobile WV, Ryan S, Shih MS, et al: Recombinant human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in class III furcation defects. J Periodontol 1998; 69: 129-137.
8. Grgić M, Jelić M, Basić V, et al: Regeneration of articular cartilage defects in rabbits by osteogenic protein-1 (bone morphogenetic protein-7). Acta Med Croatica 1997; 51: 23-27.
9. Ming W, Jinxiang H: The study of biological activity of rhBMP-7 in vitro and in vivo. Pharm Biotechnol 2004; 11: 141-145.
10. Yalan R, Jie Z, Chuan L, et al: Expression of human bone morphogenetic protein-7 in insect's cells. Bull Acad Mil Med Sci 2000; 24: 165.
11. Puelacher WC, Kim SW, Vacanti JP, et al: Tissue-engineered growth of cartilage: the effect of varying the concentration of chondrocytes seeded onto synthetic polymer matrices. Int J Oral Maxillofac Surg 1994; 23: 49-53.
12. Noguchi T, Oka M, Fujino M, et al: Repair of osteochondral defects with grafts of cultured chondrocytes. Comparison of allografts and isografts. Clin Orthop Relat Res 1994; May: 251-258.