The first total synthesis of novel human chymase inhibitor SPF32629A

Tetrahedron Letters

Volumn 49, Issue 44, 2008, Pages 6297-6299

  Vegi, Srinivasa Rao ^a,b   Boovanahalli, Shanthaveerappa K ^a   Sharma, Arun Prakash ^a   Mukkanti, K ^b  

^a GVK BIOSCIENCES PVT LTD   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMASE INHIBITOR; PYRIDINE 1 OXIDE; SPF 32629A; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; DEBENZYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; GRIGNARD REACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 51849135339     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.08.048     Document Type: Article

References (14)

1. Tomimori Y., Muto T., Fukami H., Saito K., Horikawa C., Tsuruoka N., Saito M., Sugiura N., Yamashiro K., Sumida M., Kakutani S., and Fukuda Y. Lab. Invest. 82 (2002) 789-794
2. Watanabe N., Tomimori Y., Saito K., Miura K., Wada A., Tsudzuki M., and Fukuda Y. Int. Arch. Allergy Immunol. 128 (2002) 229-234
3. Kokkonen J.O., Lindstedt K.A., and Kovanen P.T. Circulation 107 (2003) 2522-2524
4. Matsumoto T., Wada A., Tsutamoto T., Ohnishi M., Isono T., and Kinoshita M. Circulation 107 (2003) 2555-2558
5. Kanemitsu H., Takai S., Tsuneyoshi H., Nishina T., Yoshikawa K., Miyazaki M., Ikeda T., and Komeda M. Hypertens. Res. 29 (2006) 57-64
6. Tomimori Y., Muto T., Saito K., Tanaka T., Maruoka H., Sumida M., Fukami H., and Fukuda Y. Eur. J. Pharmacol. 478 (2003) 179-185
7. Sakaguchi M., Takai S., Jin D., Okamoto Y., Muramatsu M., Kim S., and Miyazaki M. Eur. J. Pharmacol. 493 (2004) 173-176
8. Takai S., Jin D., Muramatsu M., Okamoto Y., and Miyazaki M. Eur. J. Pharmacol. 501 (2004) 1-8
9. Muto T., and Fukami H. IDrugs 5 (2002) 1141-1150
10. Shimatani T., Hosotani N., Ohnishi M., Kumagai K., and Saji I. J. Antibiot. 591 (2006) 29-34
11. Shimatani T., and Hosoya Y. Japanese Patent 2004067584, 2004. Chem. Abstr. 140 (2004) 216278
12. Ochiai E. J. Org. Chem. 18 (1953) 534-551
13. Fife W.K. J. Org. Chem. 48 (1983) 1375-1377
14. 3): δ 7.38 (6H, m), 7.33-7.25 (4H, m), 6.92 (1H, d, J 2 Hz), 6.75 (1H, s), 6.56 (1H, d, J 1.6 Hz), 5.07 (2H, s), 2.44 (2H, d, J 7.2 Hz), 2.30 (2H, d, J 7.2 Hz), 2.22 (1H, m), 2.14 (1H, m), 1.04 (3H, s), 1.02 (3H, s), 0.95 (3H, s), 0.93 (3H, s)