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Volumn 159, Issue 4, 2008, Pages 773-779

Are placebo-controlled trials of creams for athlete's foot still justified?

Author keywords

Athlete's foot; Ethics; Placebo controlled randomized trials; Randomized controlled trials; Systematic review; Vehicle controls

Indexed keywords

10 UNDECENOIC ACID; ALLYLAMINE DERIVATIVE; ANTIFUNGAL AGENT; BIFONAZOLE; BUTENAFINE; CICLOPIROXOLAMINE; CLOTRIMAZOLE; DRUG VEHICLE; ECONAZOLE; MICONAZOLE NITRATE; NAFTIFINE; OXICONAZOLE; PLACEBO; PYRROLE DERIVATIVE; SULCONAZOLE; TEA TREE OIL; TERBINAFINE; TIOCONAZOLE; TOLCICLATE; TOLNAFTATE; UNCLASSIFIED DRUG; UNDECANOATE DERIVATIVE; UNDECYLENATE ZINC;

EID: 51849104610     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2008.08806.x     Document Type: Review
Times cited : (7)

References (46)
  • 1
    • 33746147596 scopus 로고
    • Clinical trials: A scientific discipline
    • Blank H. Clinical trials: a scientific discipline. J Invest Dermatol 1961 37 : 235 40.
    • (1961) J Invest Dermatol , vol.37 , pp. 235-40
    • Blank, H.1
  • 2
    • 0024512890 scopus 로고
    • Effect of investigator bias on clinical trials
    • Smith EB. Effect of investigator bias on clinical trials. Arch Dermatol 1989 125 : 216 18.
    • (1989) Arch Dermatol , vol.125 , pp. 216-18
    • Smith, E.B.1
  • 4
    • 0037231510 scopus 로고    scopus 로고
    • Trials, evidence and the management of the patient with psoriasis
    • Rees JL. Trials, evidence and the management of the patient with psoriasis. J Am Acad Dermatol 2003 48 : 135 43.
    • (2003) J Am Acad Dermatol , vol.48 , pp. 135-43
    • Rees, J.L.1
  • 5
    • 0038636510 scopus 로고    scopus 로고
    • Randomized clinical trials for psoriasis 1977-2000: The EDEN survey
    • Naldi L, Svensson A, Diepgen T et al. Randomized clinical trials for psoriasis 1977-2000: the EDEN survey. J Invest Dermatol 2003 120 : 738 41.
    • (2003) J Invest Dermatol , vol.120 , pp. 738-41
    • Naldi, L.1    Svensson, A.2    Diepgen, T.3
  • 6
    • 0000559516 scopus 로고
    • Medical ethics and controlled trials
    • Bradford-Hill A. Medical ethics and controlled trials. Br Med J 1963 i : 1043 40.
    • (1963) Br Med J , vol.1 , pp. 1043-40
    • Bradford-Hill, A.1
  • 7
    • 0004177253 scopus 로고    scopus 로고
    • The World Medical Association. Available at: (last accessed 1 June 2008).
    • The World Medical Association. Declaration of Helsinki. 2004. Available at: http://www.wma.net/e/policy/b3.htm (last accessed 1 June 2008).
    • (2004) Declaration of Helsinki.
  • 8
    • 84921431339 scopus 로고    scopus 로고
    • Topical treatments for fungal infections of the skin and nails of the foot
    • Crawford F, Hollis S. Topical treatments for fungal infections of the skin and nails of the foot. Cochrane Database Syst Rev 2007 3 : CD001434.
    • (2007) Cochrane Database Syst Rev , vol.3
    • Crawford, F.1    Hollis, S.2
  • 9
    • 0003638576 scopus 로고    scopus 로고
    • The Cochrane Collaboration. Available at: (last accessed 1 June 2008).
    • The Cochrane Collaboration. The Cochrane Database of Systematic Reviews. Available at: http://www.cochrane.org/ (last accessed 1 June 2008).
    • The Cochrane Database of Systematic Reviews.
  • 10
    • 5044233596 scopus 로고    scopus 로고
    • Alderson, P., Green, S., Higgins, J.P.T. (. eds). Chichester: Wiley
    • Alderson P, Green S, Higgins JPT (eds). Cochrane Reviewers' Handbook 4.2.2. Chichester : Wiley, 2004.
    • (2004) Cochrane Reviewers' Handbook 4.2.2.
  • 13
    • 0024442791 scopus 로고
    • Sulconazole nitrate 1% cream in the treatment of chronic moccasin-type tinea pedis caused by Trichophyton rubrum
    • Akers WA, Lane A, Lynfield Y et al. Sulconazole nitrate 1% cream in the treatment of chronic moccasin-type tinea pedis caused by Trichophyton rubrum. J Am Acad Dermatol 1989 21 : 686 9.
    • (1989) J Am Acad Dermatol , vol.21 , pp. 686-9
    • Akers, W.A.1    Lane, A.2    Lynfield, Y.3
  • 14
    • 10744229754 scopus 로고    scopus 로고
    • Ciclopirox gel in the treatment of patients with interdigital tinea pedis
    • Aly R, Fisher G, Katz HI et al. Ciclopirox gel in the treatment of patients with interdigital tinea pedis. Int J Dermatol 2003 42 (Suppl. 1 29 35.
    • (2003) Int J Dermatol , vol.42 , Issue.1 , pp. 29-35
    • Aly, R.1    Fisher, G.2    Katz, H.I.3
  • 15
    • 0022979308 scopus 로고
    • Elimination of dermatophytes causing tinea pedis interdigitalis with once daily application of bifonazole 1% solution
    • Bagatell FK. Elimination of dermatophytes causing tinea pedis interdigitalis with once daily application of bifonazole 1% solution. Adv Ther 1986 3 : 265 71.
    • (1986) Adv Ther , vol.3 , pp. 265-71
    • Bagatell, F.K.1
  • 16
    • 0025940665 scopus 로고
    • Naftifine gel in the treatment of tinea pedis: Two double-blind, multicenter studies
    • Bagatell FK, Bart BJ, Cole GW et al. Naftifine gel in the treatment of tinea pedis: two double-blind, multicenter studies. Cutis 1991 48 : 85 8.
    • (1991) Cutis , vol.48 , pp. 85-8
    • Bagatell, F.K.1    Bart, B.J.2    Cole, G.W.3
  • 17
    • 0026736111 scopus 로고
    • Efficacy of a 1-week, twice-daily regimen of terbinafine 1% cream in the treatment of interdigital tinea pedis
    • Berman B, Ellis C, Leyden J et al. Efficacy of a 1-week, twice-daily regimen of terbinafine 1% cream in the treatment of interdigital tinea pedis. J Am Acad Dermatol 1992 26 : 956 60.
    • (1992) J Am Acad Dermatol , vol.26 , pp. 956-60
    • Berman, B.1    Ellis, C.2    Leyden, J.3
  • 18
    • 0018877657 scopus 로고
    • Efficacy of undecylenic acid-zinc undecylenate powder in culture positive tinea pedis
    • Chretien JH, Esswein JG, Sharpe LM et al. Efficacy of undecylenic acid-zinc undecylenate powder in culture positive tinea pedis. Int J Dermatol 1980 19 : 51 4.
    • (1980) Int J Dermatol , vol.19 , pp. 51-4
    • Chretien, J.H.1    Esswein, J.G.2    Sharpe, L.M.3
  • 19
    • 0023008923 scopus 로고
    • Management of tinea pedis interdigitalis with bifonazole 1% cream: Double blind study
    • Coffey W. Management of tinea pedis interdigitalis with bifonazole 1% cream: double blind study. Adv Ther 1986 3 : 301 7.
    • (1986) Adv Ther , vol.3 , pp. 301-7
    • Coffey, W.1
  • 20
    • 0024819708 scopus 로고
    • Once daily naftifine cream 1% (Naftin) in the treatment of tinea pedis
    • Dobson RL, Binder R, Hickman JG et al. Once daily naftifine cream 1% (Naftin) in the treatment of tinea pedis. Clin Trials J 1989 26 : 418 23.
    • (1989) Clin Trials J , vol.26 , pp. 418-23
    • Dobson, R.L.1    Binder, R.2    Hickman, J.G.3
  • 21
    • 0029798808 scopus 로고    scopus 로고
    • Comparison of an antifungal agent used alone with an antifungal used with a topical steroid in inflammatory tinea pedis
    • Elewski B, Jones T, Zaias N. Comparison of an antifungal agent used alone with an antifungal used with a topical steroid in inflammatory tinea pedis. Cutis 1996 58 : 305 7.
    • (1996) Cutis , vol.58 , pp. 305-7
    • Elewski, B.1    Jones, T.2    Zaias, N.3
  • 22
    • 0024357223 scopus 로고
    • A placebo controlled evaluation of once daily vs twice daily oxiconazole nitrate (1%) cream in the treatment of tinea pedis
    • Ellis CN, Gammon WR, Goldfarb MT et al. A placebo controlled evaluation of once daily vs twice daily oxiconazole nitrate (1%) cream in the treatment of tinea pedis. Curr Ther Res 1989 46 : 269 76.
    • (1989) Curr Ther Res , vol.46 , pp. 269-76
    • Ellis, C.N.1    Gammon, W.R.2    Goldfarb, M.T.3
  • 23
    • 0026000358 scopus 로고
    • Two week treatment of tinea pedis with terbinafine: A placebo controlled study
    • Evans EGV, James IGV, Joshipura RC. Two week treatment of tinea pedis with terbinafine: a placebo controlled study. J Dermatolog Treat 1991 2 : 95 7.
    • (1991) J Dermatolog Treat , vol.2 , pp. 95-7
    • Evans, E.G.V.1    James, I.G.V.2    Joshipura, R.C.3
  • 24
    • 0018899962 scopus 로고
    • Comparison between undecylenic acid and tolnaftate in the treatment of tinea pedis
    • Fuerst JF, Cox GF, Weaver SM, Duncan WC. Comparison between undecylenic acid and tolnaftate in the treatment of tinea pedis. Cutis 1980 25 : 544 9.
    • (1980) Cutis , vol.25 , pp. 544-9
    • Fuerst, J.F.1    Cox, G.F.2    Weaver, S.M.3    Duncan, W.C.4
  • 25
    • 0016619608 scopus 로고
    • Efficacy of miconazole in the topical treatment of tinea pedis in sportsmen
    • Gentles JC, Jones GR, Roberts DT. Efficacy of miconazole in the topical treatment of tinea pedis in sportsmen. Br J Dermatol 1975 93 : 79 84.
    • (1975) Br J Dermatol , vol.93 , pp. 79-84
    • Gentles, J.C.1    Jones, G.R.2    Roberts, D.T.3
  • 26
    • 0023024778 scopus 로고
    • Efficacy of tolciclate solution in patients with tinea pedis
    • Gomez EC, Huntley AC, Isseroff R, Tanji J. Efficacy of tolciclate solution in patients with tinea pedis. Clin Ther 1986 8 : 694 9.
    • (1986) Clin Ther , vol.8 , pp. 694-9
    • Gomez, E.C.1    Huntley, A.C.2    Isseroff, R.3    Tanji, J.4
  • 27
    • 0025123891 scopus 로고
    • Once daily application of econazole nitrate in the treatment of tinea pedis
    • Ison AE, Lufrano L, Thorne EG. Once daily application of econazole nitrate in the treatment of tinea pedis. Adv Ther 1990 7 : 119 23.
    • (1990) Adv Ther , vol.7 , pp. 119-23
    • Ison, A.E.1    Lufrano, L.2    Thorne, E.G.3
  • 28
    • 0022869582 scopus 로고
    • A double blind study of bifonazole 1% cream applied once daily in the treatment of tinea (pityriasis) versicolor and tinea pedis interdigitalis
    • Izuno GT. A double blind study of bifonazole 1% cream applied once daily in the treatment of tinea (pityriasis) versicolor and tinea pedis interdigitalis. Adv Ther 1986 3 : 308 33.
    • (1986) Adv Ther , vol.3 , pp. 308-33
    • Izuno, G.T.1
  • 29
    • 0021228528 scopus 로고
    • [Antimycotic naftifine. Placebo-controlled comparison in tinea pedis]
    • Klaschka F, Gartmann H, Weidinger G. [Antimycotic naftifine. Placebo-controlled comparison in tinea pedis]. Z Hautkr 1984 59 : 1218 26.
    • (1984) Z Hautkr , vol.59 , pp. 1218-26
    • Klaschka, F.1    Gartmann, H.2    Weidinger, G.3
  • 30
    • 0021879234 scopus 로고
    • Evaluation of ciclopirox olamine cream for the treatment of tinea pedis: Multicentre double blind comparative studies
    • Kligman AM, Bogaert H, Cordero C et al. Evaluation of ciclopirox olamine cream for the treatment of tinea pedis: multicentre double blind comparative studies. Clin Ther 1985 7 : 409 17.
    • (1985) Clin Ther , vol.7 , pp. 409-17
    • Kligman, A.M.1    Bogaert, H.2    Cordero, C.3
  • 31
    • 0034859353 scopus 로고    scopus 로고
    • One week terbinafine 1% cream (Lamisil) once daily is effective in the treatment of interdigital tinea pedis: A vehicle controlled study. LAS-INT-06 Study Group
    • Korting HC, Tietz HJ, Bräutigam M et al. One week terbinafine 1% cream (Lamisil) once daily is effective in the treatment of interdigital tinea pedis: a vehicle controlled study. LAS-INT-06 Study Group. Med Mycol 2001 39 : 335 40.
    • (2001) Med Mycol , vol.39 , pp. 335-40
    • Korting, H.C.1    Tietz, H.J.2    Bräutigam, M.3
  • 32
    • 0016386887 scopus 로고
    • Miconazole treatment for severe dermatophytoses
    • Mandy SH, Garrott TC. Miconazole treatment for severe dermatophytoses. JAMA 1974 230 : 72 5.
    • (1974) JAMA , vol.230 , pp. 72-5
    • Mandy, S.H.1    Garrott, T.C.2
  • 33
    • 33750314522 scopus 로고    scopus 로고
    • Efficacy and safety of a new single-dose terbinafine 1% formulation in patients with tinea pedis (athlete's foot): A randomized, double-blind, placebo-controlled study
    • Ortonne JP, Korting HC, Viguié-Vallanet C et al. Efficacy and safety of a new single-dose terbinafine 1% formulation in patients with tinea pedis (athlete's foot): a randomized, double-blind, placebo-controlled study. J Eur Acad Dermatol Venereol 2006 20 : 1307 13.
    • (2006) J Eur Acad Dermatol Venereol , vol.20 , pp. 1307-13
    • Ortonne, J.P.1    Korting, H.C.2    Viguié-Vallanet, C.3
  • 34
    • 0036062173 scopus 로고    scopus 로고
    • Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: A randomized, placebo-controlled, blinded study
    • Satchell AC, Saurajen A, Bell C, Barnetson RS. Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo-controlled, blinded study. Australas J Dermatol 2002 45 : 175 8.
    • (2002) Australas J Dermatol , vol.45 , pp. 175-8
    • Satchell, A.C.1    Saurajen, A.2    Bell, C.3    Barnetson, R.S.4
  • 35
    • 0025081493 scopus 로고
    • Treatment of chronic tinea pedis (athlete's foot type) with topical terbinafine
    • Savin RC. Treatment of chronic tinea pedis (athlete's foot type) with topical terbinafine. J Am Acad Dermatol 1990 23 : 786 9.
    • (1990) J Am Acad Dermatol , vol.23 , pp. 786-9
    • Savin, R.C.1
  • 36
    • 0028256160 scopus 로고
    • Efficacy of terbinafine 1% cream in the treatment of moccasin-type tinea pedis: Results of placebo-controlled multicenter trials
    • Savin R, Atton AV, Bergstresser PR et al. Efficacy of terbinafine 1% cream in the treatment of moccasin-type tinea pedis: results of placebo-controlled multicenter trials. J Am Acad Dermatol 1994 30 : 663 7.
    • (1994) J Am Acad Dermatol , vol.30 , pp. 663-7
    • Savin, R.1    Atton, A.V.2    Bergstresser, P.R.3
  • 37
    • 0031058383 scopus 로고    scopus 로고
    • One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: A multicenter, double-blind trial
    • Savin R, De Villez RL, Elewski B et al. One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: a multicenter, double-blind trial. J Am Acad Dermatol 1997 36 : S15 19.
    • (1997) J Am Acad Dermatol , vol.36
    • Savin, R.1    De Villez, R.L.2    Elewski, B.3
  • 38
    • 0025153590 scopus 로고
    • The safety and efficacy of naftifine cream 1% in the treatment of tinea pedis
    • Schachner LA, Bagatell FK, Whittington CV et al. The safety and efficacy of naftifine cream 1% in the treatment of tinea pedis. Adv Ther 1990 7 : 148 52.
    • (1990) Adv Ther , vol.7 , pp. 148-52
    • Schachner, L.A.1    Bagatell, F.K.2    Whittington, C.V.3
  • 40
    • 0022878206 scopus 로고
    • Treatment of interdigital tinea pedis and tinea (pityriasis) versicolor with bifonazole 1% solution applied once daily
    • Smith EB, Tschen E. Treatment of interdigital tinea pedis and tinea (pityriasis) versicolor with bifonazole 1% solution applied once daily. Adv Ther 1986 3 : 250 6.
    • (1986) Adv Ther , vol.3 , pp. 250-6
    • Smith, E.B.1    Tschen, E.2
  • 41
    • 0024241360 scopus 로고
    • Topical tioconazole in tinea pedis
    • Smith EB, Becker LE, Tschen EH et al. Topical tioconazole in tinea pedis. Adv Ther 1988 5 : 313 18.
    • (1988) Adv Ther , vol.5 , pp. 313-18
    • Smith, E.B.1    Becker, L.E.2    Tschen, E.H.3
  • 42
    • 0025093253 scopus 로고
    • A clinical trial of topical terbinafine (a new allylamine antifungal) in the treatment of tinea pedis
    • Smith EB, Noppakun N, Newton RC. A clinical trial of topical terbinafine (a new allylamine antifungal) in the treatment of tinea pedis. J Am Acad Dermatol 1990 23 : 790 4.
    • (1990) J Am Acad Dermatol , vol.23 , pp. 790-4
    • Smith, E.B.1    Noppakun, N.2    Newton, R.C.3
  • 43
    • 0017263821 scopus 로고
    • Clinical evaluation of clotrimazole. a broad-spectrum antifungal agent
    • Spiekermann PH, Young MD. Clinical evaluation of clotrimazole. A broad-spectrum antifungal agent. Arch Dermatol 1976 112 : 350 2.
    • (1976) Arch Dermatol , vol.112 , pp. 350-2
    • Spiekermann, P.H.1    Young, M.D.2
  • 44
    • 0034086620 scopus 로고    scopus 로고
    • Butenafine 1% versus terbinafine 1% in cream for the treatment of tinea pedis - A placebo-controlled, double-blind, comparative study
    • Syed TA, Hadi SM, Qureshi ZA et al. Butenafine 1% versus terbinafine 1% in cream for the treatment of tinea pedis - a placebo-controlled, double-blind, comparative study. Clin Drug Invest 2000 19 : 393 7.
    • (2000) Clin Drug Invest , vol.19 , pp. 393-7
    • Syed, T.A.1    Hadi, S.M.2    Qureshi, Z.A.3
  • 46
    • 0031054949 scopus 로고    scopus 로고
    • Treatment of interdigital tinea pedis with a 4 week once-daily regimen of butenafine hydrochloride 1% cream
    • Tschen E, Elewski B, Gorsulowsky DC, Pariser DM. Treatment of interdigital tinea pedis with a 4 week once-daily regimen of butenafine hydrochloride 1% cream. J Am Acad Dermatol 1997 36 : 9 14.
    • (1997) J Am Acad Dermatol , vol.36 , pp. 9-14
    • Tschen, E.1    Elewski, B.2    Gorsulowsky, D.C.3    Pariser, D.M.4


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