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Volumn 3, Issue 4, 2008, Pages 257-261

Targeted therapy: Can it substitute for chemotherapy?

Author keywords

Breast cancer; Epidermal growth factor receptors; Targeted therapies; Vascular epidermal growth factors

Indexed keywords

ANTHRACYCLINE; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; LAPATINIB; NAVELBINE; PACLITAXEL; PERTUZUMAB; SORAFENIB; SUNITINIB; TRASTUZUMAB;

EID: 51849092585     PISSN: 16613791     EISSN: 16613805     Source Type: Journal    
DOI: 10.1159/000149816     Document Type: Review
Times cited : (1)

References (27)
  • 1
    • 0032445260 scopus 로고    scopus 로고
    • HER-2/neu as a predictive marker of response to breast cancer therapy
    • Pegram MD, Pauletti G, Slamon DJ:HER-2/neu as a predictive marker of response to breast cancer therapy. Breast Cancer Res Treat 1998;52:65-77.
    • (1998) Breast Cancer Res Treat , vol.52 , pp. 65-77
    • Pegram, M.D.1    Pauletti, G.2    Slamon, D.J.3
  • 5
    • 26844503270 scopus 로고    scopus 로고
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith I, Gianni L, Baselga J, Bell R, Jackisch C, Cameron D, Dowsett M, Barrios CH, Steger G, Huang CS, Andersson M, Inbar M, Lichinitser M, Láng I, Nitz U, Iwata H, Thomssen C, Lohrisch C, Suter TM, Rüschoff J, Suto T, Greatorex V, Ward C, Straehle C, McFadden E, Dolci MS, Gelber RD; Herceptin Adjuvant (HERA) Trial Study Team: Trastuzumab after adjuvant chemotherapy for operable HER2 positive breast cancer. N Engl J Med 2005;353:1659-1672.
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith I, Gianni L, Baselga J, Bell R, Jackisch C, Cameron D, Dowsett M, Barrios CH, Steger G, Huang CS, Andersson M, Inbar M, Lichinitser M, Láng I, Nitz U, Iwata H, Thomssen C, Lohrisch C, Suter TM, Rüschoff J, Suto T, Greatorex V, Ward C, Straehle C, McFadden E, Dolci MS, Gelber RD; Herceptin Adjuvant (HERA) Trial Study Team: Trastuzumab after adjuvant chemotherapy for operable HER2 positive breast cancer. N Engl J Med 2005;353:1659-1672.
  • 6
    • 33645720799 scopus 로고    scopus 로고
    • Phase III-randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (ACT) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (ACTH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study
    • Slamon DJ, Eiermann W, Robert N: Phase III-randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (ACT) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (ACTH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study. Breast Cancer Res Treat 2005;94 (suppl 5).
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.SUPPL. 5
    • Slamon, D.J.1    Eiermann, W.2    Robert, N.3
  • 8
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 9
    • 15544391142 scopus 로고    scopus 로고
    • Angiogenesis of breast cancer
    • Schneider BP, Miller KD: Angiogenesis of breast cancer. J Clin Oncol 2005;23:1782-1790.
    • (2005) J Clin Oncol , vol.23 , pp. 1782-1790
    • Schneider, B.P.1    Miller, K.D.2
  • 10
    • 0028115003 scopus 로고
    • Association of vascular first endothelial growth factor expression with tumor angiogenesis and with early first relapse in primary breast cancer
    • Toi M, Hoshina S, Takayanagi T, Tominaga I: Association of vascular first endothelial growth factor expression with tumor angiogenesis and with early first relapse in primary breast cancer. Jpn J Cancer Res 1994;85:1045-1049.
    • (1994) Jpn J Cancer Res , vol.85 , pp. 1045-1049
    • Toi, M.1    Hoshina, S.2    Takayanagi, T.3    Tominaga, I.4
  • 11
    • 51849106658 scopus 로고    scopus 로고
    • Bevacizumab in the treatment of breast cancer
    • Schuetz F, Sohn C, Schneeweiss A: Bevacizumab in the treatment of breast cancer. Breast Care 2006;2:62-63.
    • (2006) Breast Care , vol.2 , pp. 62-63
    • Schuetz, F.1    Sohn, C.2    Schneeweiss, A.3
  • 12
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK: Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 16
    • 54249120945 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (MBC): AVADO
    • abstr 1011
    • Miles D, Chan A, Romieu G, Dirix LY, Cortes JA, Pivot P, Tomczak T, Taran T, Harbeck N, Steger GG: Randomized, double-blind, placebo-controlled, phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (MBC): AVADO. J Clin Oncol 2008(suppl):abstr 1011.
    • J Clin Oncol , vol.2008 , Issue.SUPPL.
    • Miles, D.1    Chan, A.2    Romieu, G.3    Dirix, L.Y.4    Cortes, J.A.5    Pivot, P.6    Tomczak, T.7    Taran, T.8    Harbeck, N.9    Steger, G.G.10
  • 17
    • 0012689224 scopus 로고    scopus 로고
    • Phase II trial of the anti-VEGF antibody bevacizumab in combination with vinorelbine for refractory advanced breast cancer
    • abstr 446
    • Burstein H, Parker L, Savoie J, et al: Phase II trial of the anti-VEGF antibody bevacizumab in combination with vinorelbine for refractory advanced breast cancer. Breast Cancer Res Treat 2002;76:S115(abstr 446).
    • (2002) Breast Cancer Res Treat , vol.76
    • Burstein, H.1    Parker, L.2    Savoie, J.3
  • 18
    • 33750947804 scopus 로고    scopus 로고
    • Weekly carboplatin and nab-paclitaxel plus trastuzumab, or plus or minus bevacizumab: Clinical response in patients with breast cancer
    • abstr 10699
    • Bernstein JA, Schubbert T, Kong K, Mehta RS: Weekly carboplatin and nab-paclitaxel plus trastuzumab, or plus or minus bevacizumab: clinical response in patients with breast cancer. J Clin Oncol 2007;24(suppl):abstr 10699.
    • (2007) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Bernstein, J.A.1    Schubbert, T.2    Kong, K.3    Mehta, R.S.4
  • 19
    • 51849157552 scopus 로고    scopus 로고
    • Baselga J, Cameron D, Miles D, et al: Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T. J Clin Oncol 2007;25, No. 188(suppl):abstr 1004.
    • Baselga J, Cameron D, Miles D, et al: Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T. J Clin Oncol 2007;25, No. 188(suppl):abstr 1004.
  • 20
    • 0000109509 scopus 로고    scopus 로고
    • Harris AL: Bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer
    • Koukourakis MI, Giatromanolaki A, O'Byrne KJ, Cox J, Krammer B, Gatter KC, Harris AL: bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer. Clin Exp Metastasis 1999;17:545-554.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 545-554
    • Koukourakis, M.I.1    Giatromanolaki, A.2    O'Byrne, K.J.3    Cox, J.4    Krammer, B.5    Gatter, K.C.6
  • 21
    • 0035906852 scopus 로고    scopus 로고
    • Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway
    • Clarke K, Smith K, Gullick WJ, Harris AL: Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway. Br J Cancer 2001;84:1322-1329.
    • (2001) Br J Cancer , vol.84 , pp. 1322-1329
    • Clarke, K.1    Smith, K.2    Gullick, W.J.3    Harris, A.L.4
  • 22
    • 0034212763 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
    • Bruns CJ, Solorzano CC, Harbison MT, Ozawa S, Tsan R, Fan D, Abbruzzese J, Traxler P, Buchdunger E, Radinsky R, Fidler IJ: Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res 2000;60:2926-2935.
    • (2000) Cancer Res , vol.60 , pp. 2926-2935
    • Bruns, C.J.1    Solorzano, C.C.2    Harbison, M.T.3    Ozawa, S.4    Tsan, R.5    Fan, D.6    Abbruzzese, J.7    Traxler, P.8    Buchdunger, E.9    Radinsky, R.10    Fidler, I.J.11
  • 23
    • 1842543455 scopus 로고    scopus 로고
    • HER2-overexpressing human breast cancer xenografts exhibit increased angiogenic potential mediated by vascular endothelial growth factor (VEGF)
    • abstr 570
    • Epstein M, Ayala R, Tchekmedyian N, et al: HER2-overexpressing human breast cancer xenografts exhibit increased angiogenic potential mediated by vascular endothelial growth factor (VEGF). Breast Cancer Res Treat 2002;76:S143(abstr 570).
    • (2002) Breast Cancer Res Treat , vol.76
    • Epstein, M.1    Ayala, R.2    Tchekmedyian, N.3
  • 25
    • 0035394833 scopus 로고    scopus 로고
    • Acquired resistance to the antitumor epidermal growth factor receptor-blocking antibodies in vivo: A role for tumor angiogenesis
    • Viloria-Petit A, Crombet T, Jothy S, Hicklin D, Bohlen P, Schlaeppi JM, Rak J, Kerbel RS: Acquired resistance to the antitumor epidermal growth factor receptor-blocking antibodies in vivo: A role for tumor angiogenesis. Cancer Res 2001;61:5090-5101.
    • (2001) Cancer Res , vol.61 , pp. 5090-5101
    • Viloria-Petit, A.1    Crombet, T.2    Jothy, S.3    Hicklin, D.4    Bohlen, P.5    Schlaeppi, J.M.6    Rak, J.7    Kerbel, R.S.8
  • 26
    • 21044443432 scopus 로고    scopus 로고
    • Phase I combined biological therapy of breast cancer using two humanized monoclonal antibodies directed against HER2 proto-oncogene and vascular endothelial growth factor (VEGF)
    • abstr 3039
    • Pegram M, Yeon C, Ku N, et al: Phase I combined biological therapy of breast cancer using two humanized monoclonal antibodies directed against HER2 proto-oncogene and vascular endothelial growth factor (VEGF). Breast Cancer Res Treat 2004;88:S124(abstr 3039).
    • (2004) Breast Cancer Res Treat , vol.88
    • Pegram, M.1    Yeon, C.2    Ku, N.3
  • 27
    • 33746933715 scopus 로고    scopus 로고
    • Circulating endothelial cell (CEC) and tumor cell (CTC) analysis in patients receiving bevacizumab and erlotinib for metastatic breast cancer (MBC)
    • abstr 3088
    • Rugo H, Dickler M, Statt J, et al: Circulating endothelial cell (CEC) and tumor cell (CTC) analysis in patients receiving bevacizumab and erlotinib for metastatic breast cancer (MBC). Breast Cancer Res Treat 2004;88:5142(abstr 3088).
    • (2004) Breast Cancer Res Treat , vol.88 , pp. 5142
    • Rugo, H.1    Dickler, M.2    Statt, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.