Anti-flagellin antibodies in irritable bowel syndrome: Another attack on our commensals?

Neurogastroenterology and Motility

Volumn 20, Issue 10, 2008, Pages 1081-1085

  Ivison, S M ^a   Steiner, T S ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

Flagellin; Inflammatory bowel disease; Irritable bowel syndrome

Indexed keywords

FLAGELLIN; FLAGELLIN ANTIBODY; UNCLASSIFIED DRUG;

BACTERIAL INFECTION; COMMENSAL; DISEASE SEVERITY; GENETIC POLYMORPHISM; HISTOPATHOLOGY; HUMAN; IMMUNE RESPONSE; INFLAMMATION; IRRITABLE COLON; MICROORGANISM; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; ANTIBODIES; FLAGELLIN; HUMANS; IRRITABLE BOWEL SYNDROME; SYMBIOSIS;

EID: 51849090038     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2008.01199.x     Document Type: Review

References (31)

1. Agrawal A., Whorwell PJ. Irritable bowel syndrome: diagnosis and management. BMJ 2006 332 : 280 3.
2. Bercik P, Verdu EF, Collins SM. Is irritable bowel syndrome a low-grade inflammatory bowel disease? Gastroenterol Clin North Am 2005 34 : 235 45.
3. Chadwick VS, Chen W, Shu D et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 2002 122 : 1778 83.
4. Marshall JS. Mast-cell responses to pathogens. Nat Rev Immunol 2004 4 : 787 99.
5. Barbara G, Stanghellini V, De Giorgio R et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004 126 : 693 702.
6. Tornblom H, Lindberg G, Nyberg B, Veress B. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 2002 123 : 1972 9.
7. van der Veek PP, van den Berg M, de Kroon YE, Verspaget HW, Masclee AA. Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome. Am J Gastroenterol 2005 100 : 2510 6.
8. O'Mahony L, McCarthy J, Kelly P et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 2005 128 : 541 51.
9. Liebregts T, Adam B, Bredack C et al. Immune activation in patients with irritable bowel syndrome. Gastroenterology 2007 132 : 913 20.
10. Aerssens J, Camilleri M, Talloen W et al. Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2008 6 : 194 205.
11. Rodriguez LA, Ruigomez A. Increased risk of irritable bowel syndrome after bacterial gastroenteritis: cohort study. BMJ 1999 318 : 565 6.
12. Spiller RC. Postinfectious irritable bowel syndrome. Gastroenterology 2003 124 : 1662 71.
13. Anand AC, Reddy PS, Saiprasad GS, Kher SK. Does non-dysenteric intestinal amoebiasis exist? Lancet 1997 349 : 89 92.
14. Marshall JK, Thabane M, Borgaonkar MR, James C. Postinfectious irritable bowel syndrome after a food-borne outbreak of acute gastroenteritis attributed to a viral pathogen. Clin Gastroenterol Hepatol 2007 5 : 457 60.
15. Spiller RC, Jenkins D, Thornley JP et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000 47 : 804 11.
16. Mossner R, Lesch KP. Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav Immun 1998 12 : 249 71.
17. Gwee KA, Collins SM, Read NW et al. Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome. Gut 2003 52 : 523 6.
18. Chavez AM, Menconi MJ, Hodin RA, Fink MP. Cytokine-induced intestinal epithelial hyperpermeability: role of nitric oxide. Crit Care Med 1999 27 : 2246 51.
19. Schoepfer AM, Trummler M, Seeholzer P, Seibold-Schmid B, Seibold F. Discriminating IBD from IBS: comparison of the test performance of fecal markers, blood leukocytes, CRP, and IBD antibodies. Inflamm Bowel Dis 2008 14 : 32 9.
20. Landers CJ, Cohavy O, Misra R et al. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology 2002 123 : 689 99.
21. Brandwein SL, McCabe RP, Cong Y et al. Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J Immunol 1997 159 : 44 52.
22. Lodes MJ, Cong Y, Elson CO et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 2004 113 : 1296 306.
23. Sitaraman SV, Klapproth JM, Moore DA III. et al. Elevated flagellin-specific immunoglobulins in Crohn's disease. Am J Physiol Gastrointest Liver Physiol 2005 288 : G403 6.
24. Duck LW, Walter MR, Novak J et al. Isolation of flagellated bacteria implicated in Crohn's disease. Inflamm Bowel Dis 2007 13 : 1191 201.
25. Targan SR, Landers CJ, Yang H et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology 2005 128 : 2020 8.
26. Parish CR. Immune response to chemically modified flagellin. I. Induction of antibody tolerance to flagellin by acetoacetylated derivatives of the protein. J Exp Med 1971 134 : 1 20.
27. Parish CR, Wistar R, Ada GL. Cleavage of bacterial flagellin with cyanogen bromide. Antigenic properties of the protein fragments. Biochem J 1969 113 : 501 6.
28. Gewirtz AT, Vijay-Kumar M, Brant SR, Duerr RH, Nicolae DL, Cho JH. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. Am J Physiol Gastrointest Liver Physiol 2006 290 : G1157 63.
29. Rhee SH, Im E, Riegler M, Kokkotou E, O'brien M, Pothoulakis C. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A 2005 102 : 13610 5.
30. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004 118 : 229 41.
31. Vijay-Kumar M, Sanders CJ, Taylor RT et al. Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest 2007 117 : 3909 21.