Mouse hematopoietic stem cells, unlike human and mouse embryonic stem cells, exhibit checkpoint-apoptosis coupling

Stem Cells and Development

Volumn 17, Issue 5, 2008, Pages 1017-1020

  Rohrabaugh, Sara ^a,b   Mantel, Charlie ^a,b   Broxmeyer, Hal E ^a,b,c  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; NOCODAZOLE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CYCLE ARREST; CELL EXPANSION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME ACTIVATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MITOSIS SPINDLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CELL CYCLE; CYTOLOGY; DRUG EFFECT; METABOLISM; MICROTUBULE; MITOSIS;

MURINAE;

ANIMALS; APOPTOSIS; CELL CYCLE; EMBRYONIC STEM CELLS; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; NOCODAZOLE;

EID: 51849087656     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2007.0260     Document Type: Article

References (14)

1. Gillett E and P Sorger. (2001). Tracing the pathway of spindle assembly checkpoint signaling. Developmental Cell 1:162-164.
2. Amon A. (1999). The spindle checkpoint. Curr Opin Genet Dev 9:69-75.
3. Iwanaga Y, K Takefumi, K Kibler, KT Jeang. (2002). Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function. J Biol Chem 277:31005-31013.
4. Li Y and R Benezra. (1996). Identification of a human mitotic checkpoint gene: hsMAD2. Science 274:246-248.
5. Homer HA. (2006). Mad2 and spindle assembly checkpoint function during meiosis I in mammalian oocytes. Histol Histopathol 21:873-886.
6. Bharadwaj R and Y Hongtao. (2004). The spindle checkpoint, aneuploidy, and cancer. Oncogene 23:2016-2027.
7. Jallepalli PV and C Lengauer. (2001). Chromosome segregation and cancer: cutting through the mystery. Nature Reviews Cancer 1:109-117.
8. Wassmann K and R Benezra. (2001). Mitotic checkpoints: from yeast to cancer. Curr Opin Genet Dev 11:83-90.
9. Mantel C, Y Guo, MR Lee, MK Han, H Shibayama, S Fukuda, MC Yoder, LM Pelus, KS Kim and HE Broxmeyer. (2007). Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotypic instability. Blood 109:4518-4527.
10. Lanni JS and T Jacks. (1998). Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol 18:1055-1064.
11. Lanni JS, SW Lowe, EJ Licitra, JO Liu and T Jacks. (1997). p53-independent apoptosis induced by paclitaxel through an indirect mechanism. Proc Natl Acad Sci USA 94:9679-9683.
12. Damelin M, YE Sun, VB Sodja and TH Bestor. (2005). Decantenation checkpoint deficiency in stem and progenitor cells. Cancer Cell 8:479-484.
13. Hendzel MJ, Y Wei, MA Mancini, A Van Hooser, T Ranalli, BR Brinkley, DP Bazett-Jones and CD Allis. (1997). Mitotsisspecific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106:348-360.
14. Gunsilius E, G Gastl and AL Petzer. (2001). Hematopoietic stem cells. Biomed Pharmacother 55:186-194.