"Inject-mix-react-separate-and-quantitate" (IMReSQ) method for screening enzyme inhibitors

Journal of the American Chemical Society

Volumn 130, Issue 36, 2008, Pages 11862-11863

  Wong, Edmund ^a   Okhonin, Victor ^a   Berezovski, Maxim V ^a   Nozaki, Tomoyoshi ^b   Waldmann, Herbert ^c   Alexandrov, Kirill ^c   Krylov, Sergey N ^a  

^a YORK UNIVERSITY   (Canada)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; FTI 343; FTI 591; FTI 651; FTI 656; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; COMPUTER SIMULATION; DRUG POTENCY; FLUORESCENCE ANALYSIS; IC 50; MASS SPECTROMETRY; QUANTITATIVE ANALYSIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE;

EID: 51749123114     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja804544x     Document Type: Article

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