Synthesis and evaluation of the 5-fluorouracil-pectin conjugate targeted at the colon

Medicinal Chemistry Research

Volumn 16, Issue 7-9, 2007, Pages 370-379

  Wang, Qing Wei ^a   Liu, Xue Ying ^a   Liu, Li ^a   Feng, Juan ^a   Li, Yu Hua ^a   Guo, Zhen Jun ^a   Mei, Qi Bing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

5 Fluorouracil; Colon specific delivery system; Pectin

Indexed keywords

FLUOROURACIL; FLUOROURACIL 1 ACETIC ACID; FLUOROURACIL DERIVATIVE; PECTIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CECUM; COLON; CONJUGATE; DRUG TARGETING; EVALUATION; GASTROINTESTINAL TRACT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; STOMACH JUICE; SYNTHESIS; TARGET ORGAN;

EID: 51749122242     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-007-9049-0     Document Type: Article

References (10)

1. ZH Huang ZL Lin JL Huang 2001 A novel kind of antitumor drugs using sulfonamide as parent compound Eur J Med Chem 36 863 872
2. N Kemeny 1996 Colorectal cancer- an undertreated disease Anticancer Drugs 7 623 629
3. FQ Lu ZX Zhuang J Cao GT Mi CX Wang ZX Mu 2004 Synthesis and release of the prodrug of chitosan-5-fluorouracil J Shandong University (Health Sciences) 42 226 228
4. T Masao 1975 Antineoplastic agents. The preparation of 5-fluorouracil-1-acid derivatives Bull Chem Soc Jpn 48 3427 3428
5. P Nangia-Makker V Hogan S Baccarini L Tai A Raz 2002 Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin J Natl Cancer Inst 24 1854 1862
6. Y Ohya H Kobayashi T Ouchi 1991 Design of poly (α-malic acid)-5FU-saccharide conjugate exhibiting antitumor activity Reactive Polym 15 153 163
7. P Piedbois M Buyse Y Rustum C Machover 1992 Modulaton of fluorouracil by leucoworin in patients with advanced colorectal cancer. Evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Projecto J Clin Oncol 10 896 903
8. KL Shantha P Ravichandran RK Panduranga 1995 Azo polymeric hyrogels for colon targeted drug delivery Biomaterials 16 1313 1315
9. VR Sinha R Kumria 2001 Polysaccharides in colon-specific drug delivery Int J Pharm 224 19 38
10. Yu HQ (2005) Synthesis of the glycosides of 5-fluorouracil and study on their activity. Master's Thesis. Hua Zhong Normal University