Alpha-synuclein mRNA levels correspond to Beck Depression Inventory scores in females with eating disorders

Neuropsychobiology

Volumn 58, Issue 1, 2008, Pages 48-52

  Frieling, Helge ^a   Gozner, Andreas ^a   Römer, Konstanze D ^a   Wilhelm, Julia ^a   Hillemacher, Thomas ^a,c   Kornhuber, Johannes ^a   De Zwaan, Martina ^a   Jacoby, Georg E ^b   Bleich, Stefan ^a,c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Hospital for Eating Disorders   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Synuclein; Beck Depression Inventory; Eating disorders; Gene expression; Major depressive disorder

Indexed keywords

ALPHA SYNUCLEIN; MESSENGER RNA;

ADULT; ANOREXIA NERVOSA; ARTICLE; BECK DEPRESSION INVENTORY; BULIMIA; CLINICAL ARTICLE; DEPRESSION; FEMALE; GENE EXPRESSION; HUMAN; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ALPHA-SYNUCLEIN; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; DEPRESSION; EATING DISORDERS; FEMALE; HUMANS; PREDICTIVE VALUE OF TESTS; PSYCHOLOGICAL TESTS; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 51749104802     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000155991     Document Type: Article

References (15)

1. O'Brien KM, Vincent NK: Psychiatric comorbidity in anorexia and bulimia nervosa: nature, prevalence, and causal relationships. Clin Psychol Rev 2003;23:57-74.
2. Frieling H, Gozner A, Römer KD, Lenz B, Bönsch D, Wilhelm J, Hillemacher T, de Zwaan M, Kornhuber J, Bleich S: Global DNA hypomethylation and DNA hypermethylation of the α-synuclein promoter in females with anorexia nervosa. Mol Psychiatry 2007;12:229-230.
3. Stefanova N, Seppi K, Scherfler C, Puschban Z, Wenning GK: Depression in α-synucleinopathies: prevalence, pathophysiology and treatment. J Neural Transm Suppl 2000:335-343.
4. Perez RG, Waymire JC, Lin E, Liu JJ, Guo F, Zigmond MJ: A role for α-synuclein in the regulation of dopamine biosynthesis. J Neurosci 2002;22:3090-3099.
5. Wersinger C, Rusnak M, Sidhu A: Modulation of the trafficking of the human serotonin transporter by human α-synuclein. Eur J Neurosci 2006;24:55-64.
6. Raghavan R, Kruijff L, Sterrenburg MD, Rogers BB, Hladik CL, White CL 3rd: α-Synuclein expression in the developing human brain. Pediatr Dev Pathol 2004;7:506-516.
7. Frieling H, Römer K, Röschke B, Bönsch D, Wilhelm J, Fiszer R, de Zwaan M, Jacoby GE, Kornhuber J, Bleich S: Homocysteine plasma levels are elevated in females with anorexia nervosa. J Neural Transm 2005;112:979-985.
8. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J: An inventory for measuring depression. Arch Gen Psychiatry 1961;4:561-571.
9. Bönsch D, Reulbach U, Bayerlein K, Hillemacher T, Kornhuber J, Bleich S: Elevated α-synuclein mRNA levels are associated with craving in patients with alcoholism. Biol Psychiatry 2004;56:984-986.
10. Uversky VN: Neuropathology, biochemistry, and biophysics of α-synuclein aggregation. J Neurochem 2007;103:17-37.
11. Nestler EJ, Carlezon WA Jr: The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 2006;59:1151-1159.
12. Kaye WH, Frank GK, McConaha C: Altered dopamine activity after recovery from restricting-type anorexia nervosa. Neuropsychopharmacology 1999;21:503-506.
13. Miller DW, Hague SM, Clarimon J, Baptista M, Gwinn-Hardy K, Cookson MR, Singleton AB: α-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology 2004;62:1835-1838.
14. Kennedy SH, Kaplan AS, Garfinkel PE, Rockert W, Toner B, Abbey SE: Depression in anorexia nervosa and bulimia nervosa: discriminating depressive symptoms and episodes. J Psychosom Res 1994;38:773-782.
15. Murakami K, Tachi T, Washizuka T, Ikuta N, Miyake Y: A comparison of purging and non-purging eating disorder patients in comorbid personality disorders and psychopathology. Tokai J Exp Clin Med 2002;27:9-19.