-
1
-
-
24944535307
-
Multistep skin cancer in mice as a model to study the evolvability of cancer cells
-
Kemp CJ. Multistep skin cancer in mice as a model to study the evolvability of cancer cells. Semin Cancer Biol 2005;15:460-73.
-
(2005)
Semin Cancer Biol
, vol.15
, pp. 460-473
-
-
Kemp, C.J.1
-
2
-
-
0033992478
-
p53 and human cancer: The first ten thousand mutations
-
Hainaut P, Hollstein M. p53 and human cancer: the first ten thousand mutations. Adv Cancer Res 2000;77:81-137.
-
(2000)
Adv Cancer Res
, vol.77
, pp. 81-137
-
-
Hainaut, P.1
Hollstein, M.2
-
3
-
-
0032192140
-
The complexity of p53 modulation: Emerging patterns from divergent signals
-
Giaccia AJ, Kastan MB. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 1998;12:2973-83.
-
(1998)
Genes Dev
, vol.12
, pp. 2973-2983
-
-
Giaccia, A.J.1
Kastan, M.B.2
-
4
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2:594-604.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
5
-
-
33745823159
-
The ATM-mediated DNA-damage response: Taking shape
-
Shiloh Y. The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci 2006;31:402-10.
-
(2006)
Trends Biochem Sci
, vol.31
, pp. 402-410
-
-
Shiloh, Y.1
-
6
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin S, Moyal L, Shieh S, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998;281:1674-7.
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
Moyal, L.2
Shieh, S.3
-
7
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
Canman CE, Lim DS, Cimprich KA, et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998;281:1677-9.
-
(1998)
Science
, vol.281
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.S.2
Cimprich, K.A.3
-
8
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
-
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000;14:289-300.
-
(2000)
Genes Dev
, vol.14
, pp. 289-300
-
-
Shieh, S.Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
10
-
-
0035339357
-
ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage
-
Maya R, Balass M, Kim ST, et al. ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev 2001;15:1067-77.
-
(2001)
Genes Dev
, vol.15
, pp. 1067-1077
-
-
Maya, R.1
Balass, M.2
Kim, S.T.3
-
11
-
-
33748054298
-
ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage
-
Dornan D, Shimizu H, Mah A, et al. ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science 2006;313:1122-6.
-
(2006)
Science
, vol.313
, pp. 1122-1126
-
-
Dornan, D.1
Shimizu, H.2
Mah, A.3
-
12
-
-
3242876404
-
Ataxia-telangiectasia, an evolving phenotype
-
Chun HH, Gatti RA. Ataxia-telangiectasia, an evolving phenotype. DNA Repair (Amst) 2004;3:1187-96.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 1187-1196
-
-
Chun, H.H.1
Gatti, R.A.2
-
13
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
Xu Y, Ashley T, Brainerd EE, et al. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 1996;10:2411-22.
-
(1996)
Genes Dev
, vol.10
, pp. 2411-2422
-
-
Xu, Y.1
Ashley, T.2
Brainerd, E.E.3
-
14
-
-
15844426692
-
Atm-deficient mice: A paradigm of ataxia telangiectasia
-
Barlow C, Hirotsune S, Paylor R, et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 1996;86:159-71.
-
(1996)
Cell
, vol.86
, pp. 159-171
-
-
Barlow, C.1
Hirotsune, S.2
Paylor, R.3
-
15
-
-
0030879563
-
atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
-
Westphal CH, Rowan S, Schmaltz C, et al. atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet 1997;16:397-401.
-
(1997)
Nat Genet
, vol.16
, pp. 397-401
-
-
Westphal, C.H.1
Rowan, S.2
Schmaltz, C.3
-
16
-
-
0032949352
-
Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction
-
Liao MJ, Yin C, Barlow C, Wynshaw-Boris A, Van Dyke T. Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction. Mol Cell Biol 1999;19:3095-102.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3095-3102
-
-
Liao, M.J.1
Yin, C.2
Barlow, C.3
Wynshaw-Boris, A.4
Van Dyke, T.5
-
17
-
-
31944451363
-
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc
-
Pusapati RV, Rounbehler RJ, Hong S, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A 2006;103:1446-51.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1446-1451
-
-
Pusapati, R.V.1
Rounbehler, R.J.2
Hong, S.3
-
18
-
-
34547129356
-
Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis
-
Maclean KH, Kastan MB, Cleveland JL. Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. Mol Cancer Res 2007;5:705-11.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 705-711
-
-
Maclean, K.H.1
Kastan, M.B.2
Cleveland, J.L.3
-
20
-
-
0030667522
-
Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways
-
Barlow C, Brown KD, Deng CX, Tagle DA, Wynshaw-Boris A. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways. Nat Genet 1997;17:453-6.
-
(1997)
Nat Genet
, vol.17
, pp. 453-456
-
-
Barlow, C.1
Brown, K.D.2
Deng, C.X.3
Tagle, D.A.4
Wynshaw-Boris, A.5
-
21
-
-
0029821651
-
Dual roles of ATM in the cellular response to radiation and in cell growth control
-
Xu Y, Baltimore D. Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev 1996;10:2401-10.
-
(1996)
Genes Dev
, vol.10
, pp. 2401-2410
-
-
Xu, Y.1
Baltimore, D.2
-
22
-
-
0032524070
-
Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
-
Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 1998;280:1089-91.
-
(1998)
Science
, vol.280
, pp. 1089-1091
-
-
Herzog, K.H.1
Chong, M.J.2
Kapsetaki, M.3
Morgan, J.I.4
McKinnon, P.J.5
-
23
-
-
37849052466
-
Atm is not required for p53 induction and apoptosis in irradiated epithelial tissues
-
Gurley KE, Kemp CJ. Atm is not required for p53 induction and apoptosis in irradiated epithelial tissues. Mol Cancer Res 2007;5:1312-8.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 1312-1318
-
-
Gurley, K.E.1
Kemp, C.J.2
-
24
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis VG, Vassiliou LV, Karakaidos P, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005;434:907-13.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
-
25
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova J, Horejsi Z, Koed K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005;434:864-70.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
-
26
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
Bartkova J, Rezaei N, Liontos M, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006;444:633-7.
-
(2006)
Nature
, vol.444
, pp. 633-637
-
-
Bartkova, J.1
Rezaei, N.2
Liontos, M.3
-
27
-
-
33845269825
-
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
-
Di MR, Fumagalli M, Cicalese A, et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 2006;444:638-42.
-
(2006)
Nature
, vol.444
, pp. 638-642
-
-
Di, M.R.1
Fumagalli, M.2
Cicalese, A.3
-
28
-
-
0022527161
-
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
-
Quintanilla M, Brown K, Ramsden M, Balmain A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 1986;322:78-80.
-
(1986)
Nature
, vol.322
, pp. 78-80
-
-
Quintanilla, M.1
Brown, K.2
Ramsden, M.3
Balmain, A.4
-
29
-
-
0026349058
-
Loss of heterozygosity and mutational alterations of the p53 gene in skin tumors of interspecific hybrid mice
-
Burns PA, Kemp CJ, Gannon JV, et al. Loss of heterozygosity and mutational alterations of the p53 gene in skin tumors of interspecific hybrid mice. Oncogene 1991;6:2363-9.
-
(1991)
Oncogene
, vol.6
, pp. 2363-2369
-
-
Burns, P.A.1
Kemp, C.J.2
Gannon, J.V.3
-
30
-
-
0027203921
-
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
-
Kemp CJ, Donehower LA, Bradley A, Balmain A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 1993;74:813-22.
-
(1993)
Cell
, vol.74
, pp. 813-822
-
-
Kemp, C.J.1
Donehower, L.A.2
Bradley, A.3
Balmain, A.4
-
31
-
-
0035734285
-
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
-
Jonkers J, Meuwissen R, van der GH, et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet 2001;29:418-25.
-
(2001)
Nat Genet
, vol.29
, pp. 418-425
-
-
Jonkers, J.1
Meuwissen, R.2
van der, G.H.3
-
32
-
-
19344364856
-
p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways
-
Kelly-Spratt KS, Gurley KE, Yasui Y, Kemp CJ. p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways. PLoS Biol 2004;2:1138-49.
-
(2004)
PLoS Biol
, vol.2
, pp. 1138-1149
-
-
Kelly-Spratt, K.S.1
Gurley, K.E.2
Yasui, Y.3
Kemp, C.J.4
-
33
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998;273:5858-68.
-
(1998)
J Biol Chem
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
34
-
-
26244439873
-
ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells
-
McManus KJ, Hendzel MJ. ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells. Mol Biol Cell 2005;16:5013-25.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 5013-5025
-
-
McManus, K.J.1
Hendzel, M.J.2
-
35
-
-
25144461206
-
Phosphorylation of histone H2AX at M phase in human cells without DNA damage response
-
Ichijima Y, Sakasai R, Okita N, et al. Phosphorylation of histone H2AX at M phase in human cells without DNA damage response. Biochem Biophys Res Commun 2005;336:807-12.
-
(2005)
Biochem Biophys Res Commun
, vol.336
, pp. 807-812
-
-
Ichijima, Y.1
Sakasai, R.2
Okita, N.3
-
36
-
-
35148886818
-
Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ
-
Koike M, Mashino M, Sugasawa J, Koike A. Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ. Biochem Biophys Res Commun 2007;363:1009-12.
-
(2007)
Biochem Biophys Res Commun
, vol.363
, pp. 1009-1012
-
-
Koike, M.1
Mashino, M.2
Sugasawa, J.3
Koike, A.4
-
37
-
-
1942538492
-
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
-
Stiff T, O'Driscoll M, Rief N, et al. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res 2004;64:2390-6.
-
(2004)
Cancer Res
, vol.64
, pp. 2390-2396
-
-
Stiff, T.1
O'Driscoll, M.2
Rief, N.3
-
38
-
-
0032504784
-
-
Palmero I, Pantoja C, Serrano M. p19ARF links the tumour suppressor p53 to Ras. Nature 1998;395:125-6.
-
Palmero I, Pantoja C, Serrano M. p19ARF links the tumour suppressor p53 to Ras. Nature 1998;395:125-6.
-
-
-
-
39
-
-
33747819484
-
ARF and p53: An unsettled case
-
Sherr CJ. Divorcing ARF and p53: an unsettled case. Nat Rev Cancer 2006;6:663-73.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 663-673
-
-
Divorcing, S.C.J.1
-
40
-
-
0027521657
-
Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice
-
Harvey M, McArthur MJ, Montgomery CA, Jr., et al. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat Genet 1993;5:225-9.
-
(1993)
Nat Genet
, vol.5
, pp. 225-229
-
-
Harvey, M.1
McArthur, M.J.2
Montgomery Jr., C.A.3
-
42
-
-
0028176453
-
Tumour incidence,spectrum and ploidy in mice with a large deletion in the p53 gene
-
Purdie CA, Harrison DJ, Peter A, et al. Tumour incidence,spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene 1994;9:603-9.
-
(1994)
Oncogene
, vol.9
, pp. 603-609
-
-
Purdie, C.A.1
Harrison, D.J.2
Peter, A.3
-
43
-
-
0028168643
-
p53 deficient mice are extremely susceptible to radiation-induced tumorigenesis
-
Kemp CJ, Wheldon T, Balmain A. p53 deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat Genet 1994;8:66-9.
-
(1994)
Nat Genet
, vol.8
, pp. 66-69
-
-
Kemp, C.J.1
Wheldon, T.2
Balmain, A.3
-
44
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka S, Ballif BA, Smogorzewska A, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007;316:1160-6.
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
-
45
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 2006;443:214-7.
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
Ringshausen, I.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
46
-
-
0033563099
-
Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma
-
Liao MJ, Van Dyke T. Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma. Genes Dev 1999;13:1246-50.
-
(1999)
Genes Dev
, vol.13
, pp. 1246-1250
-
-
Liao, M.J.1
Van Dyke, T.2
-
47
-
-
33747097562
-
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
-
Bredemeyer AL, Sharma GG, Huang CY, et al. ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature 2006;442:466-70.
-
(2006)
Nature
, vol.442
, pp. 466-470
-
-
Bredemeyer, A.L.1
Sharma, G.G.2
Huang, C.Y.3
-
49
-
-
0033587776
-
The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
-
Vasioukhin V, Degenstein L, Wise B, Fuchs E. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A 1999;96:8551-6.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 8551-8556
-
-
Vasioukhin, V.1
Degenstein, L.2
Wise, B.3
Fuchs, E.4
-
50
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992;356:215-21.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
-
51
-
-
0027981995
-
Rapid allelotype analysis of p53 knockout mice
-
Timme TL, Thompson TC. Rapid allelotype analysis of p53 knockout mice. Biotechniques 1994;17:462-3.
-
(1994)
Biotechniques
, vol.17
, pp. 462-463
-
-
Timme, T.L.1
Thompson, T.C.2
|