Liver biopsy in patients infected with chronic hepatitis C and persistently normal serum ALT levels

Journal of the Liaquat University of Medical and Health Sciences

Volumn 7, Issue 2, 2008, Pages 87-92

  Memon, M Sadik ^a   Memon, Akber ^a   Ghani, M Hanif ^b   Khan, Noman ^a   Khatri, Naresh K ^a   Memon, Siraj ^a   Soomro, Ubaidullah ^a   Mirza, Mukhtar A ^a   Jafri, Wasim ^c  

^a ISRA UNIVERSITY HOSPITAL   (Pakistan)

^b LIAQUAT UNIVERSITY OF MEDICAL AND HEALTH SCIENCES   (Pakistan)

^c AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; FATTY LIVER; FEMALE; HEPATITIS C; HUMAN; INFLAMMATION; LIVER BIOPSY; LIVER FIBROSIS; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE;

EID: 51649120088     PISSN: 17290341     EISSN: None     Source Type: Journal    
DOI: 10.22442/jlumhs.08720151     Document Type: Article

References (21)

1. Conry-Cantilena C, VanRaden M, Gibble J, Melpolder J, Shakil AO, Viladomiu L, et al. Routes of interferon, viremia, and liver disease in blood donors found to have hepatitis C virus infection. N Engl J Med 1996; 334:1691-6.
2. Mamori S, Suzuki F, Hosaka T, Akuta N, Someya T, Kobayashi M, et al. Interferon monotherapy for patients with chronic hepatitis C and normal serum aminotransferase levels at commencement of treatment. J Gastroenterol. 2004 Aug; 39(8):776-82.
3. Alberti A, Noventa F, Benvegnu L, Boccato S, Gatta A. Prevalence of liver disease in a population of asymptomatic persons with hepatitis C virus infection. Ann Intern Med. 2002 Dec 17; 137 (12):961-4. Summary for patients in: Ann Intern Med. 2002 Dec 17; 137(12):136.
4. Kyrlagkitsis I, Portman B, Smith H, O'Grady J, Cramp ME. Liver histology and progression of fibrosis in individuals with chronic hepatitis C and persistently normal ALT. Am J Gastroenterol 2003,98:1588-93
5. Pradat P, Alberti A, Poynard T, Esteban Jl, Weiland O, Marcellin P, et al. Predictive value of ALT levels for histologic findings in chronic hepatitis C: a European collaborative study. Hepatology. 2002; 36(4 Pt 1):973-7.
6. Nutt AK, Hassan AK, Lindsay J. Liver biopsy in the evaluation of patients with CHC who have repeatedly normal or near normal serum ALT levels. Am J Med 2000; 109:62-4.
7. Jacobson IM, Russo MW, Lebovics E, Esposito S, Tobias H, Kilon F, et al. Interferon alfa-2b and ribavirin for patients with chronic hepatitis C and normal ALT: final results (abstract). Gastroenterology 2002; 122:627A.
8. Stanely SJ, Hayden GH, Pris J. Prevalence of liver disease in a population of asymptomatic persons with hepatitis C virus infection. Ann Intern Med 2002; 137:961-4.
9. Okanoue T, Makiyama A, Nakayama M, Sumida Y, Mitsuyoshi H, Nakajima T, et al. A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase. J Hepatol. 2005 Oct; 43(4):599-605.
10. Puoti C, Magrini A, Stati T, Rigato P, Montagnese F, Rossi P, et al. Clinical, histological, and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels. Hepatology. 1997 Dec; 26(6):1393-8.
11. Zeuzem S, Diago M, Gane E, Reddy KR, Pockros P, Prati D, et al. PEGASYS Study NR16071 Investigator Group. Peginterferon alfa-2a (40 kilo Daltons) and ribavirin in patients with chronic hepatitis C and normal aminotransferase levels. Gastroenterology. 2004; 127(6):1724-32.
12. Marcellin P, Levy S. Therapy of hepatitis C: patients with normal aminotransferase levels. Hepatology 1997; 26:133S-1136.
13. EASL International Consensus Conference on Hepatitis C. Paris, 26 - 28, February 1999. Consensus Statement, European Association for the Stud of Liver. J Hepatol 1999. 30:956-61.
14. Hui CK, Monto A, Belaye T, Lau E, Wright TL. Outcomes of interferon alpha and ribavirin treatment for chronic hepatitis C in patients with normal serum aminotransaminase. Gut 2003; 52:1644-1648.
15. Shiftman ML, Stewart CA. Hofmann CM, Contos MJ, Luketic VA. Sterling RK, et al. Chronic infection with hepatitis C virus in patients with elevated or persistently normal serum Alanine aminotransferase levels: comparison of hepatic histologic and response to interferon therapy. J Infect Dis 2000;182:1595-601.
16. Erardt A, Behlen-Wilm U, Adams O, Donner A, Heintges T, Haussinger D. Combination treatment of IFN alpha2b and ribavirin in patients with chronic hepatitis C and persistently normal ALTs. Dig: Dis: Sci: 2003; 48:921-25.
17. Herve S, Savoye G, Riachi G, Hellot MF, Goria O, Lerebours E, et al. Chronic hepatitis C with normal or abnormal aminotransferase levels: is it the same entity? Eur: J: Gastroenterol: Hepatol: 2001; 13:405-500.
18. Renou C, Halfon P, Pol S, Cacoub P, Jouve E, Bronowicki JP, et al. Histological features and HLA class II alleles in hepatitis C virus chronically infected patients with persistently normal alanine aminotransferase levels. Gut. 2002 Oct; 51 (4):585-90.
19. Jamal MM, Sony A, Quinn PG. Clinical features of hepatitis C infected patients with PNALT levels in the Southwestern United States. Hepatology 1999;30:1307-11.
20. Albert A, Benvegnu L, Boccato S, Ferrari A, Sebastiani G. Natural history of initially mild chronic hepatitis C. Dig Liver Dis 2004;36:646-54.
21. Delladetsima JK, Rassidakis G, Tassopoulos N. Histopathology of chronic hepatitis C in relation to epidemiological factors. J Hepatol 1996;24:27-32.