Persistence of Human Parvovirus B19 in Multipotent Mesenchymal Stromal Cells Expressing the Erythrocyte P Antigen: Implications for Transplantation

Biology of Blood and Marrow Transplantation

Volumn 14, Issue 10, 2008, Pages 1172-1179

  Sundin, Mikael ^a   Lindblom, Anna ^a   Örvell, Claes ^a,b   Barrett, A John ^c   Sundberg, Berit ^a   Watz, Emma ^a   Wikman, Agneta ^a   Broliden, Kristina ^a   Le Blanc, Katarina ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cell therapy; Hematopoietic; Transplantation; Virus

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FLUDARABINE; GLOBOSIDE; GLYCOPHORIN A; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; VIRUS DNA;

ADULT; AGED; ARTICLE; BONE MARROW CELL; CASE REPORT; CELL ISOLATION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DONOR; EX VIVO STUDY; FEMALE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOCOMPETENCE; IN VITRO STUDY; MALE; MESENCHYMAL STEM CELL; MYELOMA; NONHUMAN; PARVOVIRUS; PERIPHERAL LYMPHOCYTE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; STROMA CELL; VIREMIA; VIRUS INFECTION; VIRUS TRANSMISSION;

COCULTURE TECHNIQUES; DNA, VIRAL; HUMANS; MASS SCREENING; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; P BLOOD-GROUP SYSTEM; PARVOVIRIDAE INFECTIONS; PARVOVIRUS B19, HUMAN; RETROSPECTIVE STUDIES; TISSUE DONORS;

EID: 51649111163     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2008.08.003     Document Type: Article

References (35)

1. Dominici M., Le Blanc K., Mueller I., et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8 (2006) 315-317
2. Bruder S.P., Jaiswal N., and Haynesworth S.E. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem 64 (1997) 278-294
3. Friedenstein A.J., Petrakova K.V., Kurolesova A.I., et al. Heterotopic of bone marrow: analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6 (1968) 230-247
4. Haynesworth S.E., Goshima J., Goldberg V.M., et al. Characterization of cells with osteogenic potential from human marrow. Bone 13 (1992) 81-88
5. Pittenger M.F., Mackay A.M., Beck S.C., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
6. Le Blanc K., Rasmusson I., Sundberg B., et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363 (2004) 1439-1441
7. Ringden O., Uzunel M., Rasmusson I., et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 81 (2006) 1390-1397
8. Ljungman P. Risk assessment in haematopoietic stem cell transplantation: viral status. Best Pract Res 20 (2007) 209-217
9. Sundin M., Le Blanc K., Ringden O., et al. The role of HLA mismatch, splenectomy and recipient Epstein-Barr virus seronegativity as risk factors in post-transplant lymphoproliferative disorder following allogeneic hematopoietic stem cell transplantation. Haematologica 91 (2006) 1059-1067
10. Hebart H., and Einsele H. Clinical aspects of CMV infection after stem cell transplantation. Hum Immunol 65 (2004) 432-436
11. Sundin M., Orvell C., Rasmusson I., et al. Mesenchymal stem cells are susceptible to human herpesviruses, but viral DNA cannot be detected in the healthy seropositive individual. Bone Marrow Transplant 37 (2006) 1051-1059
12. Brown K.E., Anderson S.M., and Young N.S. Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science 262 (1993) 114-117
13. Weigel-Kelley K.A., Yoder M.C., and Srivastava A. Alpha5beta1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of beta1 integrin for viral entry. Blood 102 (2003) 3927-3933
14. Munakata Y., Saito-Ito T., Kumura-Ishii K., et al. Ku80 autoantigen as a cellular coreceptor for human parvovirus B19 infection. Blood 106 (2005) 3449-3456
15. Takahashi T., Ozawa K., Mitani K., et al. B19 parvovirus replicates in erythroid leukemic cells in vitro. J Infect Dis 160 (1989) 548-549
16. Takahashi T., Ozawa K., Takahashi K., et al. DNA replication of parvovirus B 19 in a human erythroid leukemia cell line (JK-1) in vitro. Arch Virol 131 (1993) 201-208
17. Broliden K., Tolfvenstam T., and Norbeck O. Clinical aspects of parvovirus B19 infection. J Intern Med 260 (2006) 285-304
18. Lindblom A., Isa A., Norbeck O., et al. Slow clearance of human parvovirus B19 viremia following acute infection. Clin Infect Dis 41 (2005) 1201-1203
19. Broliden K. Parvovirus B19 infection in pediatric solid-organ and bone marrow transplantation. Pediatr Transplant 5 (2001) 320-330
20. Plentz A., Hahn J., Knoll A., et al. Exposure of hematologic patients to parvovirus B19 as a contaminant of blood cell preparations and blood products. Transfusion 45 (2005) 1811-1815
21. Cooling L.L., Koerner T.A., and Naides S.J. Multiple glycosphingolipids determine the tissue tropism of parvovirus B19. J Infect Dis 172 (1995) 1198-1205
22. Srivastava A., Bruno E., Briddell R., et al. Parvovirus B19-induced perturbation of human megakaryocytopoiesis in vitro. Blood 76 (1990) 1997-2004
23. Rollin R., Alvarez-Lafuente R., Marco F., et al. Human parvovirus B19, varicella zoster virus, and human herpesvirus-6 in mesenchymal stem cells of patients with osteoarthritis: analysis with quantitative real-time polymerase chain reaction. Osteoarthritis Cartilage 15 (2007) 475-478
24. Cassinotti P., Burtonboy G., Fopp M., et al. Evidence for persistence of human parvovirus B19 DNA in bone marrow. J Med Virol 53 (1997) 229-232
25. Cossart Y.E., Field A.M., Cant B., et al. Parvovirus-like particles in human sera. Lancet 1 (1975) 72-73
26. Le Blanc K., Samuelsson H., Gustafsson B., et al. Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia 21 8 (2007) 1733-1738
27. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276 (1997) 71-74
28. Moller G. Induction of DNA synthesis in human lymphocytes: interaction between non-specific mitogens and antigens. Immunology 19 (1970) 583-598
29. Aberham C., Pendl C., Gross P., et al. A quantitative, internally controlled real-time PCR assay for the detection of parvovirus B19 DNA. J Virol Methods 92 (2001) 183-191
30. Le Blanc K., Tammik C., Rosendahl K., et al. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hhematol 31 (2003) 890-896
31. Brown K.E., Hibbs J.R., Gallinella G., et al. Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen). N Engl J Med 330 (1994) 1192-1196
32. Goessler U.R., Bugert P., Bieback K., et al. Integrin expression in stem cells from bone marrow and adipose tissue during chondrogenic differentiation. Int J Mol Med 21 (2008) 271-279
33. + erythroid progenitors are highly permissive to human parvovirus B19 replication. J Virol 82 (2008) 2470-2476
34. Scadden D.T., Zeira M., Woon A., et al. Human immunodeficiency virus infection of human bone marrow stromal fibroblasts. Blood 76 (1990) 317-322
35. Heegaard E.D., and Laub Petersen B. Parvovirus B19 transmitted by bone marrow. Br J Haematol 111 (2000) 659-661