Topical ketorolac in vitreoretinal surgery: A prospective, randomized, placebo-controlled, double-masked trial

Archives of Ophthalmology

Volumn 126, Issue 9, 2008, Pages 1203-1208

  Kim, Stephen J ^a,b,c   Lo, Wayne R ^a   Hubbard III, G Baker ^a   Srivastava, Sunil K ^a   Denny, John P ^a   Martin, Daniel F ^a   Yan, Jiong ^a   Bergstrom, Chris S ^a   Cribbs, Blaine E ^a   Schwent, Bryan J ^a   Aaberg Sr , Thomas M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETOROLAC TROMETAMOL; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERABILITY; EYE INFLAMMATION; EYE PAIN; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PUPIL DISEASE; RANDOMIZED CONTROLLED TRIAL; RETINA MACULA HOLE; RETINA TEAR; TREATMENT DURATION; VISUAL ACUITY; VITRECTOMY;

ADMINISTRATION, TOPICAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFLAMMATION; KETOROLAC TROMETHAMINE; MALE; MIDDLE AGED; OPHTHALMIC SOLUTIONS; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES; PUPIL; RETINAL DISEASES; VISUAL ACUITY; VITRECTOMY; VITREOUS BODY;

EID: 51649106232     PISSN: 00039950     EISSN: 00039950     Source Type: Journal    
DOI: 10.1001/archopht.126.9.1203     Document Type: Article

References (23)

1. Fekrat S, Elsing SH, Raja SC, et al. Eye pain after vitreoretinal surgery: a prospective study of 185 patients. Retina. 2001;21(6):627-632.
2. Staudt S, Miller DW, Unnebrink K, et al. Incidence and extent of postoperative macular edema following vitreoretinal surgery with and without combined cataract operation. Ophthalmologe. 2003;100(9):702-707.
3. Ambache N, Kavanagh L, Whiting J. Effect of mechanical stimulation on rabbits' eyes: release of active substance in anterior chamber perfusates. J Physiol. 1965;176:378-408.
4. Neufeld AH, Sears ML. Prostaglandin and eye. Prostaglandins. 1973;4(2):157-175.
5. Waitzman MB, King CD. Prostaglandin influences on intraocular pressure and pupil size. Am J Physiol. 1967;212(2):329-334.
6. Solomon KD, Turkalj JW, Whiteside SB, Stewart JA, Apple DJ. Topical 0.5% ketorolac vs 0.03% flurbiprofen for inhibition of miosis during cataract surgery. Arch Ophthalmol. 1997;115(9):1119-1122.
7. Keates RH, McGowan KA. Clinical trial of flurbiprofen to maintain pupillary dilation during cataract surgery. Ann Ophthalmol. 1984;16(10):919-921.
8. Keulen-de Vos HC, Van Rij G, Renardel de Lavalette JCG, Jansen JTG. Effect of indomethacin in preventing surgically induced miosis. Br J Ophthalmol. 1983;67(2):94-96.
9. Srinivasan R, Madhavaranga . Topical ketorolac tromethamine 0.5% versus dicloenac sodium 0.1% to inhibit miosis during cataract surgery. J Cataract Refract Surg. 2002;28(3):517-520.
10. Simone JN, Pendelton RA, Jenkins JE. Comparison of the efficacy and safety of ketorolac tromethamine 0.5% and prednisolone acetate 1% after cataract surgery. J Cataract Refract Surg. 1999;25(5):699-704.
11. Heier J, Cheetham JK, Degryse R, et al. Ketorolac tromethamine 0.5% ophthalmic solution in the treatment of moderate to severe ocular inflammation after cataract surgery: a randomized vehicle controlled clinical trial. Am J Ophthalmol. 1999;127(3):253-259.
12. Rossetti L, Chaudhuri J, Dicersin K. Medical prophylaxis and treatment of cystoid macular edema after cataract surgery-the results of a meta-analysis. Ophthalmology. 1998;105(3):397-405.
13. Yavas GF, Ozturk F, Kusbeci T. Preoperative topical indomethacin to prevent pseudophakic cystoid macular edema. J Cataract Refract Surg. 2007;33(5):804-807.
14. Reis A, Birnbaum F, Hansen LL, et al. Successful treatment of cystoid macular edema with valdecoxib. J Cataract Refract Surg. 2007;33(4):682-685.
15. Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data: results of the first international workshop. Am J Ophthalmol. 2005;140(3):509-516.
16. Donnenfeld ED, Perry HD, Wittpenn JR, et al. Preoperative ketorolac tromethamine 0.4% in phacoemulsification outcomes: pharmocokinetic-response curves. J Cataract Refract Surg. 2006;32(9):1474-1482.
17. Optical Coherence Tomography Scanner 3: Owner's Manual. Dublin, CA: Zeiss-Humphrey Systems; 2002.
18. Chan A, Duker JS, Ko TH, et al. Normal macular thickness measurements in healthy eyes using stratus optical coherence tomography. Arch Ophthalmol. 2006;124(2):193-198.
19. Kim SJ, Equi R, Bressler NM. Analysis of macular edema after cataract surgery in patients with diabetes using optical coherence tomography. Ophthalmology. 2007;114(5):881-889.
20. Schulze-Bonsel K, Feltgen N, Burau H, et al. Visual acuities "hand motion" and "counting fingers" can be quantified with the Freiburg visual acuity test. Invest Ophthalmol Vis Sci. 2006;47(3):1236-1240.
21. Fekrat S, Marsh MJ, Elsing SH. Intraoperative ketorolac and eye pain after vitreoretinal surgery: a prospective, randomized, placebo-controlled study. Retina. 2003;23(1):8-13.
22. Vlajkovic G, Sindjelic R, Stefanovic I. Ketorolac as a pre-emptive analgesic in retinal detachment surgery: a prospective, randomized clinical trial. Int J Clin Pharmacol Ther. 2007;45(5):259-263.
23. Bhatnagar P, Kaiser PK, Smith SD, et al. Reopening of previously closed macular holes after cataract extraction. Am J Ophthalmol. 2007;144(2):252-259.