Two cell lines of t(8;21) acute myeloid leukemia with activating KIT exon 17 mutation: Models for the 'second hit' hypothesis

Leukemia

Volumn 22, Issue 9, 2008, Pages 1792-1794

  Becker, H ^a   Pfeifer, D ^a   Afonso, J D ^a   Nimer, S D ^b   Veelken, H ^a   Schwabe, M ^a   Lubbert M ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STEM CELL FACTOR RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL LINE; CHROMOSOME 4; CHROMOSOME TRANSLOCATION 21; CHROMOSOME TRANSLOCATION 8; EXON; GENE MUTATION; HOMOZYGOSITY; HUMAN; HUMAN CELL; HYPOTHESIS; PRIORITY JOURNAL; UNIPARENTAL DISOMY;

CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 21; CHROMOSOMES, HUMAN, PAIR 8; EXONS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MODELS, BIOLOGICAL; MUTATION; PROTO-ONCOGENE PROTEINS C-KIT; TRANSLOCATION, GENETIC;

EID: 51649103787     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2008.61     Document Type: Article

References (10)

1. Peterson LF, Boyapati A, Ahn EY, Biggs JR, Okumura AJ, Lo MC et al Acute myeloid leukemia with the 8q22;21q22 translocation: Secondary mutational events and alternative t(8;21) transcripts. Blood 2007; 110: 799-805.
2. Yuan Y, Zhou L, Miyamoto T, Iwasaki H, Harakawa N, Hetherington CJ et al. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci USA 2001; 98: 10398-10403.
3. Schessl C, Rawat VP, Cusan M, Deshpande A, Kohl TM, Rosten PM et al The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice. J Clin Invest 2005; 115: 2159-2168.
4. Yamashita N, Osato M, Huang L, Yanagida M, Kogan SC, Iwasaki M et al Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice. Br J Haematol 2005; 131: 495-507.
5. Paschka P, Marcucci G, Ruppert AS, Mrozek K, Chen H, Kittles RA, et al. Cancer Leukemia Group B. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): A Cancer and Leukemia Group B Study. J Clin Oncol 2006; 24: 3904-3911.
6. Cairoli R, Beghini A, Grillo G, Nadali G, Elice F, Ripamonti CB et al Prognostic impact of c-KIT mutations in core binding factor leukemias: An Italian retrospective study. Blood 2006; 107: 3463-3468.
7. Schnittger S, Kohl TM, Haferlach T, Kern W, Hiddemann W, Spiekermann K et al. KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall'survival. Blood 2006; 107 1791-1799.
8. Beghini A, Magnani I, Ripamonti CB, Larizza L. Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: A t(8;21)-Kit mutant model for acute myeloid leukemia. Hematol J 2002; 3: 157-163.
9. Raghavan M, Lillington DM, Skoulakis S, Debernardi S, Chaplin T, Foot NJ et al. Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic 'recombination in acute myeloid leukemias. Cancer Res 2005; 65: 375-378.
10. Fitzgibbon J, Smith LL, Raghavan M, Smith ML, Debernardi S, Skoulakis S et al. Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias. Cancer Res 2005; 65: 9152-9154.