Molecular understanding of copper and iron interaction with α-synuclein by fluorescence analysis

Journal of Molecular Neuroscience

Volumn 35, Issue 3, 2008, Pages 273-281

  Bharathi, ^a   Rao, K S J ^a,b  

^a CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE   (India)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Synuclein; Binding; Copper; Fibrillogenesis; Intrinsic tyrosine fluorescence; Iron

Indexed keywords

ALPHA SYNUCLEIN; COPPER; IRON; MUTANT PROTEIN; MUTANT PROTEIN A30P; MUTANT PROTEIN A53T; MUTANT PROTEIN E46K; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; EXPERIMENTAL STUDY; FLUORESCENCE ANALYSIS; HUMAN; METAL BINDING; MOLECULAR DYNAMICS; PARKINSON DISEASE; SCATCHARD PLOT; WILD TYPE;

ALPHA-SYNUCLEIN; ANILINO NAPHTHALENESULFONATES; BINDING SITES; COPPER; FLUORESCENCE; FLUORESCENT DYES; HUMANS; IRON; PROTEIN BINDING; THIAZOLES; TYROSINE;

EID: 51649085755     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-008-9076-4     Document Type: Article

References (26)

1. Bharathi S. S. Indi K. S. J. Rao 2007 Copper and iron induced differential morphology of fibrils in α-synuclein: TEM study Neuroscience Letters 424 78 82
2. Bharathi K. S. J. Rao 2007 Thermodynamics imprinting reveals differential binding of metals to a-synuclein: Relevance to Parkinson's disease Biochemical and Biophysical Research Communications 359 115 120
3. K. A. Conway S. J. Lee J. C. Rochet T. T. Ding R. E. Williamson P. T. Lansbury Jr. 2000 Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy Proceedings of the National Academy of Sciences of the USA 97 571 576
4. D. T. Dexter A. Carayon F. J. Agid Y. Agid F. R. Wells S. E. Daniel 1991 Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia Brain 114 1953 1975
5. M. R. Eftink C. A. Ghiron 1981 Fluorescence quenching studies with proteins Analytical Biochemistry 114 199 227
6. M. Goedert 2001 α-synuclein and neurodegenerative diseases Nature Reviews Neuroscience 2 492 501
7. L. Guilloreau L. Damian Y. Coppel H. Mazarguil M. Winterhalter P. Faller 2006 Structural and thermodynamically properties of Cu (II) amyloid-beta16/28 complexes associated with Alzheimer's disease Journal of Biological Inorganic Chemistry 11 1024 1038
8. A. E. Iwai M. Masliah N. Yoshimoto L. Ge H. A. Flanagan A. de Silva 1995 The precursor protein of non-Ab component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system Neuron 14 467 475
9. R. Jakes M. G. Spillantini M. Goedert 1994 Identification of two distinct synucleins from human brain FEBS Letters 345 27 32
10. T. K. Jankowska A. Rajewska E. Jankowska K. Wisniewska Z. Grzonka 2006 Products of Cu (II)-catalyzed oxidation of the N-terminal fragments of alpha-synuclein in the presence of hydrogen peroxide Journal of Inorganic Biochemistry 100 1623 1631
11. D. G. Le Couteur A. J. McLean M. C. Taylor B. L. Woodham P. G. Board 1999 Pesticides and Parkinson's disease Biomedicine & Pharmacotherapy 53 122 130
12. S. K. Maji J. J. Amsden K. J. Rothschild M. M. Condron D. B. Teplow 2005 Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence Biochemistry 44 13365 13376
13. L. Maroteaux J. T. Campanelli R. H. Scheller 1998 Synuclein: A neuron specific protein localized to the nucleus and presynaptic nerve terminal Journal of Neuroscience 8 2804 2815
14. D. Matulis C. G. Baumann V. A. Bloomfield R. E. Lovrien 1999 1-Anilino-8-naphthalene sulfonate as a protein conformational tightening agent Biopolymers 49 451 458
15. D. Matulis R. Lovrien 1998 1-Anilino-8-naphthalene sulfonate anion-protein binding depends primarily on ion pair formation Biophysical Journal 74 422 429
16. N. Pandey R. E. Schmidt J. E. Galvin 2006 The alpha-synuclein mutation E46K promotes aggregation in cultured cells Experimental Neurology 197 515 520
17. G. V. Semisotnov N. A. Rodionova O. I. Razgulyaev V. N. Uversky A. F. Gripas R. I. Gilmanshin 1991 Study of the "molten globule" intermediate state in protein folding by a hydrophobic fluorescent probe Biopolymers 31 119 128
18. M. G. Spillantini R. A. Crowther R. Jakes M. Hasegawa M. Goedert 1998 Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies Proceedings of the National Academy of Sciences of the USA 95 6469 6473
19. M. G. Spillantini M. L. Schimdt V. M. Lee J. Q. Trojanowski R. Jakes M. Goedert 1997 α-synuclein in Lewy bodies Nature 388 839 840
20. Y. H. Sung C. Rospigliosi D. Eliezer 2006 NMR mapping of copper binding sites in alpha-synuclein Biochimica et Biophysica Acta 1764 5 12
21. C. M. Tanner 1989 The role of environmental toxins in the etiology of Parkinson's disease Trends in Neurosciences 12 49 54
22. V. N. Uversky J. Li A. L. Fink 2001 Evidence for a partially folded intermediate in α-synuclein fibril formation Journal of Biological Chemistry 276 10737 10744
23. V. N. Uversky J. Li A. L. Fink 2001 Metal-triggered structural transformation, aggregation and Fibrillation of Human α-synuclein, a possible molecular link between Parkinson's disease and heavy metal exposure Journal of Biological Chemistry 276 44284 44296
24. M. Yasui T. Kihira K. Ota 1992 Calcium, magnesium aluminium concentrations in Parkinson's disease Neurotoxicology 13 593 600
25. J. J. Zarranz J. Alegre J. C. Gomez-Esteban E. Lezcano R. Ros I. Ampuero 2004 The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia Annals of Neurology 55 164 173
26. L. Zecca A. Stroppolo A. Gatti D. Tampellini M. Toscani M. Gallorini 2004 The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging Proceedings of the National Academy of Sciences of the USA 101 9843 9848