Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: Heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 4982-4987

  Ganesh, Thota ^a   Thepchatri, Pahk ^a   Li, Lian ^a   Du, Yuhong ^a   Fu, Haian ^a   Snyder, James P ^a   Sun, Aiming ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

Antiproliferative activity; FP assay; Heat shock protein 90; Structure based design; Sulfonamides; Suzuki coupling

Indexed keywords

HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; N (4 HYDROXY 3 (2 HYDROXYNAPHTHALENE 1 YL)PHENYL)BENZENE SULFONAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL GROWTH; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR STRUCTURE; NAPHTHOLS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 51549106656     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.022     Document Type: Article

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