Effect of Ad-TIMP 3 on biologic behavior of choriocarcinoma cells in vitro

Journal of Reproductive Medicine for the Obstetrician and Gynecologist

Volumn 53, Issue 8, 2008, Pages 608-614

  Chen, Yan ^b   Qian, Haili ^b   Zhang, Ying ^b   Ma, Yan ^b   Lin, Chen ^b   Xiang, Yang ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b NONE

Author keywords

Apoptosis; Choriocarcinoma; Gene therapy; TIMP 3

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4',6 DIAMIDINO 2 PHENYLINDOLE; ADENOVIRUS VECTOR; MESSENGER RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CELL ADHESION; CELL INVASION; CHORIOCARCINOMA; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FLUORESCENCE ACTIVATED CELL SORTING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING; ADENOVIRUS; CANCER INVASION; FEMALE; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PREGNANCY; TUMOR CELL LINE; UTERUS CANCER;

ADENOVIRIDAE; APOPTOSIS; CELL ADHESION; CELL LINE, TUMOR; CHORIOCARCINOMA; FEMALE; GENE THERAPY; HUMANS; NEOPLASM INVASIVENESS; PREGNANCY; TISSUE INHIBITOR OF METALLOPROTEINASE-3; TRANSFECTION; UP-REGULATION; UTERINE NEOPLASMS;

EID: 51549103061     PISSN: 00247758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Lala PK, Lee BP, Xu G, et al: Human placental trophoblast as an in vitro model for tumor progression. Can J Physiol Pharmacol 2002;80:142-149
2. Shim KN, Jung SA, Joo YH, et al: Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer. J Gastroenterol 2007;42:120-128
3. Juuti A, Lundin J, Nordling S, et al: Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer. Oncology 2006;71:61-68
4. Hofmann UB, Houben R, Brocker EB, et al: Role of matrix metalloproteinases in melanoma cell invasion. Biochimie 2005;87:307-314
5. Matsunaga Y, Koda M, Murawaki Y: Expression of matrix metalloproiteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in hepatocellular carcinoma tissue, compared with the surrounding non-tumor tissue. Res Commun Mol Pathol Pharmacol 2004;115-116:143-150
6. van der Velden PA, Zuidervaart W, Hurks MH, et al: Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development. Int J Cancer 2003;106:472-179
7. Isaka K, Usuda S, Ito H, et al: Expression and activity of matrix metalloproteinase 2 and 9 in human trophoblasts. Placenta 2003;24:53-64
8. Staun-Ram E, Goldman S, Gabarin D, et al: Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion. Reprod Biol Endocrinol 2004;2:59-72
9. Xue WC, Chan KY, Feng HC, et al: Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma. J Mol Diagn 2004;6:326-34
10. Feng H, Cheung AN, Xue WC, et al: Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma. Gynecol Oncol 2004;94:375-382
11. Han X, Zhang H, Jia M, et al: Expression of TIMP-3 gene by construction of a eukaryotic cell expression vector and its role in reduction of metastasis in a human breast cancer cell line. Cell Mol Immunol 2004;1:308-310
12. Finan KM, Hodge G, Reynolds AM, et al: In vitro susceptibility to the pro-apoptotic effects of TIMP3 gene delivery translates to greater in vivo efficacy versus gene delivery for TIMPs-1 or -2. Lung Cancer 2006;53:273-284
13. Drynda A, Quax PH, Neumann M, et al: Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-alpha on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. J Immunol 2005;174:6524-6531
14. Smookler DS, Mohammed FF, Kassiri Z, et al: Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. J Immunol 2006;176:721-725
15. Yu XF, Yang C, Liang LH, et al: Inhibition of human leukemia xenograft in nude mice by adenovirus-mediated tissue inhibitor of metalloproteinase-3. Leukemia 2006;20:1-8
16. Ahonen M, Ala-Aho R, Baker AH, et al: Antitumor activity and bystander effect of adenovirally delivered tissue inhibitor of metalloproteinases-3. Mol Ther 2002;5:705-715