Synthesis and biological affinity of new imidazo- and indol-arylpiperazine derivatives: Further validation of a pharmacophore model for α1-adrenoceptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 5140-5145

  Strappaghetti, Giovannella ^a   Mastrini, Luciano ^a   Lucacchini, Antonio ^b   Giannaccini, Gino ^b   Betti, Laura ^b   Fabbrini, Laura ^b  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

1 AR affinity; 2 AR affinity; 5 HT1A affinity; 6 (Imidazol 1 yl) pyridazin 3(2H) one; 6 (Indol 1 yl) pyridazin 3(2H) one fragment; Arylpiperazines; Serotonin reuptake inhibitors (SSRI); Structure activity relationships (SARs)

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR; ARYLPIPERAZINE DERIVATIVE; INDOLE DERIVATIVE; PAROXETINE; PIPERAZINE DERIVATIVE; PRAZOSIN; RAUWOLSCINE; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; IMIDAZOLES; INDOLES; MOLECULAR STRUCTURE; PIPERAZINES; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN UPTAKE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51549085792     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.084     Document Type: Article

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