Potential endogenous immunological self-protection of uveal melanoma by indoleamine 2,3-dioxygenase;Potenzieller endogener, immunologischer schutzmechanismus uvealer melanome durch indoleamine 2,3-dioxygenase

Klinische Monatsblatter fur Augenheilkunde

Volumn 225, Issue 8, 2008, Pages 703-707

  Beutelspacher, S C ^a   Serbecic, Nermin ^b  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Augenklinik   (Austria)

Author keywords

IDO; Indoleamine 2,3 dioxygenase; T cell inactivation

Indexed keywords

GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE;

ARTICLE; CANCER CELL CULTURE; ENZYME ANALYSIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PROTEIN EXPRESSION; UPREGULATION; UVEA MELANOMA;

CELL LINE, TUMOR; HUMANS; IMMUNITY, INNATE; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MELANOMA; UVEAL NEOPLASMS;

EID: 51549084808     PISSN: 00232165     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-963788     Document Type: Article

References (23)

1. Apte RS, Sinha D, Mayhew E et al. Cutting edge: role of macrophage migration inhibitory factor in inhibiting NK cell activity and preserving immune privilege. J Immunol 1998; 12: 5693-5696
2. Belladonna ML, Puccetti P, Orabona C et al. Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes. Transplantation 2007; 1 (Suppl): S17-S20
3. Beutelspacher SC, Pillai R, Watson MP et al. Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression. Eur J Immunol 2006; 3: 690-700
4. Carlin JM, Borden EC, Sondel PM et al. Interferon-induced indoleamine 2,3-dioxygenase activity in human mononuclear phagocytes. J Leukoc Biol 1989; 1: 29-34
5. Chen PW, Mellon JK, Mayhew E et al. Uveal melanoma expression of indoleamine 2,3-deoxygenase: Establishment of an immune privileged environment by tryptophan depletion. Exp Eye Res 2007; 85: 617-625
6. Fallarino F, Grohmann U, Vacca C et al. T cell apoptosis by kynurenines. Adv Exp Med Biol 2003; 527: 183-190
7. Fujigaki S, Saito K, Sekikawa K et al. Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism. Eur J Immunol 2001; 8: 2313-2318
8. Goslings WR, Blom DJ, de Waard-Siebinga I et al. Membrane-bound regulators of complement activation in uveal melanomas. CD 46, CD 55, and CD 59 in uveal melanomas. Invest Ophthalmol Vis Sci 1996; 9: 1884-1891
9. Kwidzinski E, Bechmann I. IDO expression in the brain: a double-edged sword. J Mol Med 2007; 85: 1351-1359
10. Le Rond S, Gonzalez A, Gonzalez AS et al. Indoleamine 2,3 dioxygenase and human leucocyte antigen-G inhibit the T-cell alloproliferative response through two independent pathways. Immunology 2005; 3: 297-307
11. Malina HZ, Martin XD. Indoleamine 2,3-dioxygenase: antioxidant enzyme in the human eye. Graefes Arch Clin Exp Ophthalmol 1996; 7: 457-462
12. Mellor AL, Munn DH. Extinguishing maternal immune responses during pregnancy: implications for immunosuppression. Semin Immunol 2001; 4: 213-218
13. Mellor AL, Munn DH. Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol Today 1999; 10: 469-473
14. Muller AJ, DuHadaway JB, Donover PS et al. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat Med 2005; 3: 312-319
15. Polak ME, Borthwick NJ, Gabriel FG et al. Mechanisms of local immunosuppression in cutaneous melanoma. Br J Cancer 2007; 12: 1879-1887
16. Sedlmayr P. Indoleamine 2,3-dioxygenase in materno-fetal interaction. Curr Drug Metab 2007; 3: 205-208
17. Serbecic N, Beutelspacher SC. Indoleamine 2,3-dioxygenase protects corneal endothelial cells from UV mediated damage. Exp Eye Res 2006; 3: 416-426
18. Singh AD, Bergman L, Seregard S. Uveal melanoma: epidemiologic aspects. Ophthalmol Clin North Am 2005; 1: 75-84, viii
19. Takikawa O, Littlejohn T, Jamie JF et al. Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens. Relevance for senile nuclear cataract. Adv Exp Med Biol 1999; 467: 241-245
20. Takikawa O, Littlejohn TK, Truscott RJ. Indoleamine 2,3-dioxygenase in the human lens, the first enzyme in the synthesis of UV filters. Exp Eye Res 2001; 3: 271-277
21. Uyttenhove C, Pilotte L, Theate I et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003; 10: 1269-1274
22. von Rango U, Krusche CA, Beier HM et al. Indoleamine-dioxygenase is expressed in human decidua at the time maternal tolerance is established. J Reprod Immunol 2007; 1-2: 34-45
23. Zamanakou M, Germenis AE, Karanikas V. Tumor immune escape mediated by indoleamine 2,3-dioxygenase. Immunol Lett 2007; 2: 69-75