Solubility improvement of drugs using N-methyl pyrrolidone

AAPS PharmSciTech

Volumn 9, Issue 2, 2008, Pages 366-376

  Sanghvi, Ritesh ^a   Narazaki, Ryuichi ^b   Machatha, Stephen G ^c   Yalkowsky, Samuel H ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b EISAI CO LTD   (Japan)

^c CyDex LC   (United States)

Author keywords

Complexing agent; Cosolvent; N methyl pyrrolidone; Solubility enhancement

Indexed keywords

1 NAPHTHOIC ACID; 1,12 DECANEDIOIC ACID; 2 PHENOXYPROPIONIC ACID; 2 PYRROLIDONE DERIVATIVE; ALCOHOL; AMIODARONE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BENZOYLPHENYLUREA DERIVATIVE; CARBENDAZIM; CARBOXYLIC ACID; ESTRONE; GRISEOFULVIN; IBUPROFEN; KETOPROFEN; N METHYLPYRROLIDONE; NAPHTHALENE DERIVATIVE; PG 300995; PHENOBARBITAL; PHENYTOIN; PROPIONIC ACID; PROPYLENE GLYCOL; SEBACIC ACID; SOLVENT; TESTOSTERONE; UNCLASSIFIED DRUG; UREA DERIVATIVE; WATER; XK 469; DRUG; N-METHYLPYRROLIDONE; POLYMER; POLYPROPYLENE GLYCOL; PROPANEDIOL DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); DRUG FORMULATION; DRUG SOLUBILITY; DRUG STRUCTURE; MATHEMATICAL MODEL; SURFACE TENSION; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; METHODOLOGY; PHARMACEUTICS; SOLUBILITY; TEMPERATURE;

ETHANOL; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; POLYMERS; PROPYLENE GLYCOLS; PYRROLIDINONES; SOLUBILITY; SOLVENTS; SURFACE TENSION; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; WATER;

EID: 51449115448     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9050-z     Document Type: Article

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