An evaluation of the postoperative antihyperalgesic and analgesic effects of intrathecal clonidine administered during elective cesarean delivery

Anesthesia and Analgesia

Volumn 107, Issue 3, 2008, Pages 948-955

  Lavand'Homme, Patricia M ^a   Roelants, Fabienne ^a   Waterloos, Hilde ^a   Collet, Valerie ^a   De Kock, Marc F ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; BUPIVACAINE; CITRATE SODIUM; CLONIDINE; DICLOFENAC; EPHEDRINE; METOCLOPRAMIDE; MORPHINE; PARACETAMOL; PHENYLEPHRINE; RANITIDINE; SUFENTANIL; SUFENTANIL CITRATE; ANALGESIC AGENT; INTRAVENOUS ANESTHETIC AGENT; LOCAL ANESTHETIC AGENT;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BIRTH; CESAREAN SECTION; CONTROL GROUP; CONTROLLED STUDY; DRUG EFFECT; ELECTIVE SURGERY; FEMALE; HUMAN; HYPERALGESIA; HYPOTENSION; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PAIN ASSESSMENT; POSTOPERATIVE PAIN; PRIORITY JOURNAL; SEDATION; SIDE EFFECT; SPINAL ANESTHESIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; INTRASPINAL DRUG ADMINISTRATION; METHODOLOGY; OBSTETRIC ANALGESIA; POSTOPERATIVE PERIOD; PREGNANCY; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANALGESIA, OBSTETRICAL; ANALGESICS; ANESTHESIA, SPINAL; ANESTHETICS, INTRAVENOUS; ANESTHETICS, LOCAL; BUPIVACAINE; CESAREAN SECTION; CLONIDINE; FEMALE; HUMANS; INJECTIONS, SPINAL; PAIN, POSTOPERATIVE; POSTOPERATIVE PERIOD; PREGNANCY; SUFENTANIL;

EID: 51449097071     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e31817f1595     Document Type: Article

References (34)

1. Hamilton BE, Martin JA, Ventura SJ. Births: preliminary data for 2005. Natl Vital Stat Rep 2006;55:1-18
2. Mayor S. 23% of babies in England are delivered by cesarean section. BMJ 2005;330:860
3. Carvalho B, Cohen SE, Lipman SS, Fuller A, Mathusamy AD, Macario A. Patient preferences for anesthesia outcomes associated with cesarean delivery. Anesth Analg 2005;101:1182-7
4. Benhamou D, Thorin D, Brichant JF, Dailland P, Milon D, Schneider M. Intrathecal clonidine and fentanyl with hyperbaric bupivacaine improves analgesia during cesarean section. Anesth Analg 1998;87:609-13
5. Paech MJ, Pavy TJ, Orlikowski CE, Yeo ST, Banks SL, Evans SF, Henderson J. Postcesarean analgesia with spinal morphine, clonidine, or their combination. Anesth Analg 2004;98:1460-6
6. Pan PM, Huang CT, Wei TT, Mok MS. Enhancement of analgesic effect of intrathecal neostigmine and clonidine on bupivacaine spinal anesthesia. Reg Anesth Pain Med 1998;23:49-56
7. Eisenach JC, De Kock M, Klimscha W. Alpha(2)-adrenergic agonists for regional anesthesia. A clinical review of clonidine (1984 -1995). Anesthesiology 1996;85:655-74
8. Eisenach JC, Hood DD, Curry R. Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia. Pain 2000;84:57-64
9. Eisenach JC, Hood DD, Curry R. Intrathecal, but not intravenous, clonidine reduces experimental thermal or capsaicininduced pain and hyperalgesia in normal volunteers. Anesth Analg 1998;87:591-6
10. De Kock M, Lavand'homme P, Waterloos H. The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery. Anesth Analg 2005;101:566-72
11. Wilder-Smith OHG, Arendt-Nielsen L. Postoperative hyperalgesia. Its clinical importance and relevance. Anesthesiology 2006;104:601-7
12. Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science 2000;288:1765-8
13. Brennan TJ, Kehlet H. Preventive analgesia to reduce wound hyperalgesia and persistent postsurgical pain: not an easy path. Anesthesiology 2005;103:681-3
14. Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet 2006;367:1618-25
15. Joly V, Richebe P, Guignard B, Fletcher D, Maurette P, Sessler DI, Chauvin M. Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. Anesthesiology 2005;103:147-55
16. Stubhaug A, Breivik H, Eide PK, Kreuner M, Foss A. Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesthesiol Scand 1997;41:1124-32
17. Ilkjaer S, Bach LF, Nielsen PA, Wernberg M, Dahl JB. Effect of preoperative oral dextromethorphan on immediate and late postoperative pain and hyperalgesia after total abdominal hysterectomy. Pain 2000;86:19-24
18. Dirks J, Moiniche S, Hilsted KL, Dahl JB. Mechanisms of postoperative pain: clinical indications for a contribution of central neuronal sensitization. Anesthesiology 2002;97:1591-6
19. Brennan TJ. Frontiers in translational research: the etiology of incisional and postoperative pain. Anesthesiology 2002;97:535-7
20. Chiari AI, Eisenach JC. Intrathecal adenosine: interactions with spinal clonidine and neostigmine in rat models of acute nociception and postoperative hypersensitivity. Anesthesiology 1999;90:1413-21
21. Duflo F, Conklin D, Li X, Eisenach JC. Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain. Anesthesiology 2003;98:1237-42
22. Filos KS, Goudas LC, Patroni O, Polyzou V. Intrathecal clonidine as a sole analgesic for pain relief after cesarean section. Anesthesiology 1992;77:267-74
23. Van Elstraete AC, Sitbon P, Trabold F, Mazoit JX, Benhamou D. A single dose of intrathecal morphine in rats induces longlasting hyperalgesia: the protective effect of prior administration of ketamine. Anesth Analg 2005;101:1750-6
24. De Kock M, Lavand'homme P, Waterloos H. 'Balanced analgesia' in the perioperative period: is there a place for ketamine? Pain 2001;92:373-80
25. van Tuijl I, van Klei WA, van der Werff DB, Kalkman CJ. The effect of addition of intrathecal clonidine to hyperbaric bupivacaine on postoperative pain and morphine requirements after Caesarean section: a randomized controlled trial. Br J Anaesth 2006;97:365-70
26. Yoshimura M, Furue H. Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord. J Pharmacol Sci 2006;101:107-17
27. Kawasaki Y, Kumamoto E, Furue H, Yoshimura M. Alpha 2 adrenoceptor-mediated presynaptic inhibition of primary afferent glutamatergic transmission in rat substantia gelatinosa neurons. Anesthesiology 2003;98:682-9
28. Baba H, Shimoji K, Yoshimura M. Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord (part 1): effects on axon terminals of GABAergic and glycinergic neurons. Anesthesiology 2000;92:473-84
29. Obata H, Conklin D, Eisenach JC. Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats. Pain 2005;113:271-6
30. Moiniche S, Kehlet H, Dahl JB. A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief: the role of timing of analgesia. Anesthesiology 2002;96:725-41
31. Ong CK-S, Lirk P, Seymour RA, Jenkins BJ. The efficacy of preemptive analgesia for acute postoperative pain management: a meta-analysis. Anesth Analg 2005;100:757-73
32. Eisenach JC. Preventing chronic pain after surgery: who, how, and when? Reg Anesth Pain Med 2006;31:1-3
33. Paech MJ, Magann EF, Doherty DA, Verity LJ, Newnham JP. Does magnesium sulfate reduce the short- and long-term requirements for pain relief after caesarean delivery? A doubleblind placebo-controlled trial. Am J Obstet Gynecol 2006;194: 1596-602, discussion 602-3
34. Nikolajsen L, Sorensen HC, Jensen TS, Kehlet H. Chronic pain following Caesarean section. Acta Anaesthesiol Scand 2004; 48:111-16